General
Preferred name
ROXADUSTAT
Synonyms
FG-4592 ()
ASP1517 ()
Roxadustat (FG-4592) ()
Evrenzo ()
FG4592 ()
ASP-1517 ()
Roxadustat-d5 ()
P&D ID
PD011194
CAS
808118-40-3
2043026-13-5
Tags
available
drug
Approved by
EMA
PMDA
First approval
2019
2021
Drug indication
Anaemia
Kidney disease
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Roxadustat is a compound which inhibits hypoxia inducible factor prolyl hydroxylase (HIF-PH) activity. HIF-PH inhibitors are being investigated as novel therapies for anemia, especially anemia caused by chronic kindney disease (CKD) . It is hoped that HIF-PH inhibitors will provide a more effective alternative to the use of erythropoetin replacement therapy plus iron supplementation in CKD patients. (GtoPdb)
DESCRIPTION Enhancer of 20S proteasome assembly and 20S-mediated protein degradation (Tocris Bioactive Compound Library)
Compound Sets
21
AdooQ Bioactive Compound Library
A11237
Axon Medchem Screening Library
2588
Cayman Chemical Bioactives
15294
34235
ChEMBL Approved Drugs
CHEMBL2338329
ChEMBL Drugs
CHEMBL2338329
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB04847
DrugBank Approved Drugs
DB04847
DrugCentral
5371
DrugCentral Approved Drugs
5371
DrugMAP
DM4XSQ2
Guide to Pharmacology
8454
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL2338329
Mcule NIBR MoA Box Subset
MCULE-7812240665
MedChem Express Bioactive Compound Library
HY-13426
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
fg-4592
TargetMol Bioactive Compound Library
T2515
Tocris Bioactive Compound Library
7486
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
352.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
2.86
TPSA
108.75
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Angiogenesis
Chromatin/Epigenetic
Apoptosis
Metabolic Enzyme/Protease
Target
HIF-PH
EGLN1, EGLN2, EGLN3
HIFa-PHD inhibitor
Ferroptosis
HIF/HIF Prolyl-Hydroxylase
Ferroptosis,HIF
Primary Target
Hydroxylases
MOA
Inhibitor
hypoxia-inducible factor prolyl hydroxylase inhibitor
hypoxia inducible factor prolyl hydroxylase inhibitor
Member status
member
Source data