General
Preferred name
curcumin
Synonyms
NSC32982 ()
Diferuloylmethane ()
Natural Yellow 3 ()
Turmeric yellow ()
Indian Saffron ()
P&D ID
PD011359
CAS
15845-47-3
8024-37-1
458-37-7
Tags
covalent binder
probe
natural product
drug
nuisance
available
Drug indication
Solid tumour/cancer
Drug Status
investigational
approved
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
4
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Curcumin's physicochemical properties imply that it is an implausible clinical lead . It is unstable, reactive, and nonbioavailable, and has been identified as having attributes of both PAINS (pan-assay interference compounds) and IMPS (invalid metabolic panaceas) compounds.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
81
Organisms
9
Compound Sets
17
Bioprocess diversity set
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2023/24
CovalentInDB
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugBank Approved Drugs
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NIH Mechanistic Set
Nuisance compounds in cellular assays
Other bioactive compounds
Probe Miner (suitable probes)
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
40
Molecular Weight
368.13
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
3.37
TPSA
93.06
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
3
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Nonspecific/NOS
Curcuminoids
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Biological process
Glycosylation & protein folding/targeting, cell wall biogenesis
Pathway
NF-¦ÊB
Chromatin/Epigenetic
NF-??
Anti-infection
Apoptosis
Autophagy
Epigenetics
NF-κB
Target
p300 histone acetylatransferase
Keap1-Nrf2
Epigenetic Reader Domain
Ferroptosis
Histone Acetyltransferase
Influenza Virus
Mitophagy
Source data
