General
Preferred name
PEMPIDINE
Synonyms
PEMPIDINE TARTRATE ()
1,2,2,6,6-Pentamethylpiperidine ()
Pyrilene ()
Perolysen ()
NSC-758448 ()
Pempidina ()
P&D ID
PD012002
CAS
546-48-5
79-55-0
Tags
available
drug
Drug Status
approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
1,2,2,6,6-Pentamethylpiperidine is a ganglion-blocking drug. It is one of the most strongly basic tertiary amine. It is ued as an oral treatment for hypertension and used as an organic structure directing agent (OSDA) in the synthesis of the RTH-type zeolites. It is also used in the synthesis of BN-fused polycyclic aromatic molecules for potential application to electronic materials and apparatus. It is also a catalyst for the chemoselective silylation of benzylic alcohols.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugCentral
DrugCentral Approved Drugs
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
155.17
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
1
Aromatic Ring Count
0
cLogP
2.66
TPSA
3.24
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuroscience
Target
Nicotinic Receptor
ganglion
Indication
hypertension
MOA
ganglionic blocker
Solubility
DMSO : ≥ 2.1 mg/mL
Source data
