General
Preferred name
AMBROXOL
Synonyms
AMBROXOL HYDROCHLORIDE ()
NA-872 ()
Ambroxolum ()
Ambroxol HCl ()
Mucoangin ()
Mucosolvan ()
NA-872 (hydrochloride) ()
Ambroxol (hydrochloride) ()
Tabcin ()
Ambroxol-d5 (hydrochloride) ()
P&D ID
PD012068
CAS
18683-91-5
23828-92-4
107814-37-9
2741380-71-0
Tags
available
drug
First approval
1978
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION Ambroxol is indicated for secretolytic therapy in bronchoplmonary diseaes with abnormal mucus secretion and transport. It allows the mucus to be more easily cleared and ease a patient's breathing.
DESCRIPTION Selective P2Y11/P2X1 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Na+ channel blocker (Tocriscreen Plus)
DESCRIPTION Na+ channel blocker (Tocriscreen Total)
Compound Sets
21
Axon Medchem Screening Library
3159
Cayman Chemical Bioactives
19377
38335
ChEMBL Drugs
CHEMBL153479
Drug Repurposing Hub
DrugBank
DB06742
DrugBank Approved Drugs
DB06742
DrugCentral
147
DrugCentral Approved Drugs
147
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL153479
MedChem Express Bioactive Compound Library
HY-B1039
HY-B1039A
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
ambroxol
ambroxol-hcl
TargetMol Bioactive Compound Library
T0920
T6234
Tocris Bioactive Compound Library
2404
Tocriscreen Plus
2404
Tocriscreen Total
ZINC Tool Compounds
ZINC000100001905
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
375.98
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
3.19
TPSA
58.28
Fraction CSP3
0.54
Chiral centers
0.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Pathway
Metabolism
Membrane Transporter/Ion Channel
Autophagy
Metabolic Enzyme/Protease
Target
CYP3A
Sodium Channel
CYP3A4
Expectorant
Glucosidase
Primary Target
Voltage-gated Sodium (NaV) Channels
MOA
P450 inhibitor
Blocker
Sodium Channel inhibitor
Pulmonary surfactant
lysosomal exocytosis
Sodium Channel blocker
Member status
member
Indication
bronchitis
Source data