General
Preferred name
VORTIOXETINE
Synonyms
VORTIOXETINE HYDROBROMIDE ()
Lu AA21004 hydrobromide ()
Vortioxetine (Lu AA21004) HBr ()
Lu AA 21004 ()
Vortioxetine HBr ()
Lu AA21004 (hydrobromide) ()
Vortioxetine (hydrobromide) ()
Lu-aa21004 hydrobromide ()
Trintellix ()
Brintellix ()
Lu aa21004 hbr ()
Lu AA21004 (HBr) ()
LU AA21004 ()
Vortioxetina ()
LU-AA21004 ()
LUAA21004 ()
SF-001 ()
Vortioxetine bromide ()
SF001 ()
VORTIOXETINE HEMIHYDROBROMIDE ()
Vortioxetine-d8 ()
P&D ID
PD012584
CAS
960203-27-4
508233-74-7
2140316-62-5
Tags
available
drug candidate
drug
Approved by
FDA
EMA
PMDA
First approval
2013
Drug indication
Major depressive disorder
Mood disorder
Drug Status
approved
investigational
Max Phase
4.0
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Vortioxetine is an atypical (multimodal) antidepressant . (GtoPdb)
Cell lines
1
Organisms
0
Compound Sets
23
AdooQ Bioactive Compound Library
A12602
Cayman Chemical Bioactives
23694
30183
28163
ChEMBL Approved Drugs
CHEMBL2107387
CHEMBL2104993
ChEMBL Drugs
CHEMBL2107387
CHEMBL2104993
CHEMBL5314578
Concise Guide to Pharmacology 2017/18
7351
Concise Guide to Pharmacology 2019/20
7351
Concise Guide to Pharmacology 2021/22
7351
Concise Guide to Pharmacology 2023/24
7351
Drug Repurposing Hub
DrugBank
DB09068
DrugBank Approved Drugs
DB09068
DrugCentral
4806
DrugCentral Approved Drugs
4806
DrugMAP
DM6F1PU
DrugMAP Approved Drugs
DM6F1PU
EU-OPENSCREEN Bioactive Compound Library
EOS100018
Guide to Pharmacology
7351
MedChem Express Bioactive Compound Library
HY-15414A
HY-15414
NCATS Inxight Approved Drugs
3O2K1S3WQV
Other bioactive compounds
ReFrame library
TargetMol Bioactive Compound Library
T2395L
T2395
The Spectrum Collection
External IDs
62
Properties
(calculated by RDKit )
Molecular Weight
298.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
3.86
TPSA
15.27
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.93
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
5-HT1A
5-HT1B
5-HT3A
5-HT7
SERT
HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR5A, HTR6, HTR7, SLC6A4
5-HT Receptor
Serotonin Transporter
MOA
serotonin receptor agonist, serotonin receptor antagonist
Indication
depression
Source data