General
Preferred name
CEVIPABULIN
Synonyms
Cevipabulin (TTI-237) ()
TTI-237 ()
TTI-237 fumarate ()
Cevipabulin fumarate ()
CEVIPABULIN SUCCINATE ()
P&D ID
PD012713
CAS
849550-05-6
849550-69-2
849550-67-0
Tags
drug candidate
available
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cevipabulin, is a small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, it specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules. Cebipabulin stabilizes tubulin and inhibits microtubule disassembly. This results in cell cycle arrest at the G2/M phase, and leading to cell death.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
464.12
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
3
cLogP
4.07
TPSA
76.37
Fraction CSP3
0.39
Chiral centers
1.0
Largest ring
6.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
TUBB
Microtubule-active agent
Microtubule/Tubulin
MOA
microtubule stimulant, tubulin polymerization inhibitor
Pathway
Cell Cycle/DNA Damage
cytoskeleton
Source data
