General
Preferred name
TRIAPINE
Synonyms
NSC663249 ()
OCX191 ()
PAN-811 ()
3-AP ()
OCX-0191 ()
NSC-663249 ()
Ocx 191 ()
OCX-191 ()
P&D ID
PD013043
CAS
143621-35-6
236392-56-6
200933-27-3
Tags
available
drug candidate
Drug indication
Nerve injury
Drug Status
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent and selective PLK1 inhibitor
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
20
Organisms
0
Compound Sets
12
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
Pandemic Response Box
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
195.06
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.17
TPSA
89.32
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Target
RR
RRM1, RRM2
DNA/RNA Synthesis
DNA/RNA Synthesis,RNR
Primary Target
Ribonucleotide Reductase
MOA
Inhibitor
Ribonucleotide Reductase inhibitor
Source data
