General
Preferred name
selegiline
Synonyms
SELEGILINE HYDROCHLORIDE ()
R(-)-Deprenyl hydrochloride ()
(R)-(-)-Deprenyl hydrochloride ()
R-(-)-Deprenyl hydrochloride ()
L-deprenyl-D2 C-11 ()
Vivapryl ()
L-Deprenyl ()
Centrapryl 10 ()
Selegiline HCl ()
Centrapryl 5 ()
NSC-759259 ()
Zelapar ()
Stilline 10 ()
Stilline 5 ()
Eldepryl ()
Selegilina ()
EMSAM ()
L-selegiline ()
R-(?)-Deprenyl (hydrochloride) ()
P&D ID
PD013116
CAS
14611-51-9
102741-42-4
14611-52-0
Tags
available
drug candidate
drug
covalent binder
Approved by
FDA
First approval
1989
Drug indication
Antidyskinetic
Parkinson disease
Skin imperfections
Antiparkinsonian (in combination with levodopa/carbidopa)
Chemotherapy-induced nausea
Motor symptoms
Major depressive disorder
Drug Status
approved
vet_approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Marketed formulations may contain (PubChem CID 26758). (GtoPdb)
DESCRIPTION Adenylyl cyclase activator (Tocris Bioactive Compound Library)
Compound Sets
28
Axon Medchem Screening Library
3332
Cayman Chemical Bioactives
15046
ChEMBL Approved Drugs
CHEMBL1200904
CHEMBL972
ChEMBL Drugs
CHEMBL1200904
CHEMBL972
Concise Guide to Pharmacology 2017/18
6639
Concise Guide to Pharmacology 2019/20
6639
Concise Guide to Pharmacology 2021/22
6639
Concise Guide to Pharmacology 2023/24
6639
CovalentInDB
CI002170
Drug Repurposing Hub
DrugBank
DB01037
DB12650
DrugBank Approved Drugs
DB01037
DrugCentral
2429
DrugCentral Approved Drugs
2429
DrugMAP
DM3VR1L
DM6034S
DrugMAP Approved Drugs
DM3VR1L
DM6034S
Enamine BioReference Compounds
Guide to Pharmacology
6639
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1200904
CHEMBL972
Mcule NIBR MoA Box Subset
MCULE-3188554308
NCATS Inxight Approved Drugs
6W731X367Q
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T5050
Tocris Bioactive Compound Library
1095
External IDs
75
Properties
(calculated by RDKit )
Molecular Weight
187.14
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
2.18
TPSA
3.24
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Neuroscience
Target
MAO-B
MAOA, MAOB
MAO-B inhibitor
Primary Target
Monoamine Oxidases
MOA
MAO
Inhibitor
MAO-B Inhibitors
monoamine oxidase inhibitor
Member status
virtual
Indication
Parkinson's Disease
Therapeutic Class
Neurology Agents
Source data