General
Preferred name
BUFLOMEDIL
Synonyms
BUFLOMEDIL HYDROCHLORIDE ()
Buflomedil HCl ()
Fonzylane ()
Loftyl ()
Buflomedil HCl35543-24-9 ()
Buflomedil (hydrochloride) ()
NSC 759291 ()
P&D ID
PD013131
CAS
35543-24-9
55837-25-7
Tags
available
drug
First approval
1976
Drug indication
Peripheral vascular disease
Drug Status
experimental
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
20
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
48
Molecular Weight
307.18
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
1
cLogP
2.77
TPSA
48.0
Fraction CSP3
0.59
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Target
??-adrenergic receptor
ADRA1A
Adrenergic Receptor
MOA
adrenergic receptor antagonist, calcium channel blocker
Indication
peripheral artery disease (PAD)
ATC
C04AX20
Toxicity type
NULL
Source data
