General
Preferred name
SEROTONIN
Synonyms
SEROTONIN HYDROCHLORIDE ()
5-HT hydrochloride ()
5-Hydroxytryptamine hydrochloride ()
Serotonin HCl ()
5-HT HCl ()
5-Hydroxy Tryptamine ()
5-hydroxytryptamine ()
[3H]5-HT ()
[3H]5-HT ()
Serotonin (hydrochloride) ()
Serotonin-d4 (hydrochloride) ()
Serotonin (hydrochloride) ()
5-HT ()
Thrombotonin ()
Enteramine ()
P&D ID
PD013329
CAS
153-98-0
1094000-36-8
50-67-9
2469263-61-2
Tags
available
natural product
drug candidate
endogenous
Drug indication
Discovery agent
Drug Status
nutraceutical
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Endogenous neurotransmitter (LOPAC library)
DESCRIPTION Endogenous 5-HT receptor agonist (Tocriscreen Total)
Cell lines
1
Organisms
3
Compound Sets
26
Cayman Chemical Bioactives
14332
33680
29415
ChEMBL Drugs
CHEMBL39
Concise Guide to Pharmacology 2017/18
5
3248
Concise Guide to Pharmacology 2019/20
5
3248
Concise Guide to Pharmacology 2021/22
5
3248
Concise Guide to Pharmacology 2023/24
5
3248
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB08839
DrugMAP
DMOFCRY
DMYJXV7
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101049
EUbOPEN Chemogenomics Library
Guide to Pharmacology
5
3248
Ki Database
5-Hydroxy Tryptamine
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL39
Mcule NIBR MoA Box Subset
MCULE-8788459983
Novartis Chemogenetic Library (NIBR MoA Box)
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
serotonin-hcl
TargetMol Bioactive Compound Library
T2209
TN2437
The Spectrum Collection
Tocriscreen Total
External IDs
66
Properties
(calculated by RDKit )
Molecular Weight
176.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
1.37
TPSA
62.04
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
5-HT
COMT
DRD1, DRD5, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR4, HTR5A, HTR6, HTR7, SLC36A1
5-HT Receptor
Pathway
GPCR/G protein
Neuroscience
Metabolism
Member status
member
MOA
serotonin receptor agonist
growth factor receptor activator
Indication
anxiety, depression, sleeplessness
Recommended Cell Concentration
None
Source data