General
Preferred name
Branaplam
Synonyms
NVS-SM1 ()
LMI 070 ()
LMI070 ()
LMI070 (hydrochloride) ()
NVS-SM1 (hydrochloride) ()
Branaplam (hydrochloride) ()
Branaplam (LMI070) ()
NVP-LMI070-NX ()
LMI-070 ()
NVP-LMI070-AAA ()
BRANAPLAM HYDROCHLORIDE ()
P&D ID
PD013401
CAS
1562338-42-4
1562338-39-9
Tags
available
probe
drug candidate
Drug indication
Spinal muscular atrophy
Drug Status
investigational
Max Phase
1.0
2.0
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
Mcule NIBR MoA Box Subset
Nature Chemical Biology Probes
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
393.22
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
3.93
TPSA
95.95
Fraction CSP3
0.41
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Membrane Transporter/Ion Channel
MOA
DNA/RNA Synthesis
splicing modulator
survival motor neuron protein modulator
Member status
virtual
Target
SMN1
Potassium Channel
SMN
Source data
