General
Preferred name
TRANYLCYPROMINE
Synonyms
Tranylcypromine hydrochloride ()
2-PCPA ()
Tranylcypromine (2-PCPA) HCl ()
SKF-385 HCl ()
Tranylcypromine (2-PCPA) hydrochloride ()
(1R,2S)-(+)-tranylcypromine ()
SKF 385 (hemisulfate) ()
Tranylcypromine (hemisulfate) ()
Tranylcipromine ()
TRANYLCYPROMINE SULFATE ()
Parnate ()
(1R,2S)-2-Phenylcyclopropanaminium ()
2-Phenyl-Cyclopropylamine HCl ()
Tranylcypromine HCl ()
Rel-Tranylcypromine HCl ()
P&D ID
PD013449
CAS
1986-47-6
95-62-5
155-09-9
3721-26-4
13492-01-8
Tags
available
drug candidate
drug
obsolete probe
Approved by
FDA
First approval
1961
Drug indication
Major depressive disorder
Prostate cancer
Drug Status
experimental
approved
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tranylcypromine, an amphetamine derivative, has been found to be a MAO inhibitor that could be used an antidepressant agent and anxiolytic drug.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Topoisomerase II inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Irreversible inhibitor of LSD1; also inhibits MAO
(Tocriscreen Plus)
DESCRIPTION
Irreversible inhibitor of MAO-A, MAO-B and LSD1
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
1
Compound Sets
18
BOC Sciences Bioactive Compounds
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
LINCS compound set
MedChem Express Bioactive Compound Library
NPC Screening Collection
Obsolete Compounds
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
63
Molecular Weight
133.09
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
1.5
TPSA
26.02
Fraction CSP3
0.33
Chiral centers
2.0
Largest ring
6.0
QED
0.62
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Metabolism
Neuroscience
Chromatin/Epigenetic
Epigenetics
Neuronal Signaling
Target
MAO
LSD1
Histone Demethylase
Monoamine Oxidase
Primary Target
Histone Demethylases
MOA
Inhibitor
Therapeutic Class
Antidepressants
Source data
