General
Preferred name
SULTOPRIDE
Synonyms
LIN-1418 ()
LIN-1418 hydrochloride ()
Sultopride hydrochloride ()
ITANOXONE ()
Barnetil ()
Sultoprida ()
P&D ID
PD014091
CAS
23694-17-9
53583-79-2
55619-22-2
Tags
available
drug
Drug Status
approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Barnetil acts as a selective D2 and D3 receptor antagonist, which has high affinity for these receptors of dissociation constants of 2.2 nM and 2.4 nM respectively. It is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. It has also been shown to have clinically relevant affinity for the GHB receptor. It was launched by Sanofi-Aventis in 1976.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
Ki Database
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
354.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
1
cLogP
1.7
TPSA
75.71
Fraction CSP3
0.59
Chiral centers
1.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Dopamine Receptor
dopamine
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Solubility
Soluble in DMSO, not in water
Source data
