General
Preferred name
LY83583
Synonyms
P&D ID
PD015754
CAS
91300-60-6
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION LY83583 is an Msp1 inhibitor, a guanylate cyclase inhibitor and a cGMP modulator. LY83583 inhibits soluble guanylate cyclase in human platelets with an IC50 of 2 μM. LY83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 of 1.8 μM, and is a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with a Ki of 3 μM. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
2
Compound Sets
3
BOC Sciences Bioactive Compounds
ly83583-cas-91300-60-6-item-84-336078
Cayman Chemical Bioactives
70230
MedChem Express Bioactive Compound Library
HY-W013386
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
250.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
2.46
TPSA
59.06
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.89
Structural alerts
1
quinone_A(370)
[!#6&!#1]=[#6]-1-[#6]=,:[#6]-[#6](=[!#6&!#1])-[#6]=,:[#6]-1
PAINS Family A
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Target
Guanylate Cyclase
Solubility
Soluble in DMF, DMSO, Ethanol
Source data