General
Preferred name
ML106
Synonyms
ML197 Analog ()
6-(2H-1,3-benzodioxol-5-yl)-N-[(thiophen-2-yl)methyl]quinazolin-4-amine ()
PMID28766366-Compound-Scheme8NCGC-00010037 ()
P&D ID
PD016023
CAS
959489-44-2
Tags
drug candidate
probe
available
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
5
No orthogonal probes found
Similar probes
3
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
In this effort, we have aimed to 1) identify specific modulators of LMNA pre-mRNA splicing@ these compounds are leads in the search for drugs with therapeutic potential in HGPS and 2) identify general pre-mRNA splicing inhibitors@ these compounds will be useful as experimental tools in the study of pre-mRNA splicing mechanisms.
(MLP Probes)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
13
Molecular Weight
361.09
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
4
cLogP
4.7
TPSA
56.27
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Classification
probe analog
Antitarget
>400 kinases
Target
CLK4
Source data
