General
Preferred name
bicuculline
Synonyms
(+)-Bicuculline ()
D-Bicuculline ()
BICUCULLINE (+) ()
P&D ID
PD016205
CAS
485-49-4
Tags
available
natural product
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent GABAA antagonist
(Tocriscreen Total)
DESCRIPTION
Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
367.11
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
6
Aromatic Ring Count
2
cLogP
2.58
TPSA
66.46
Fraction CSP3
0.35
Chiral centers
2.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Neuronal Signaling
Target
GABAR
GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, KCNN1
GABA Receptor
ADC Cytotoxin,GABA Receptor
Primary Target
GABAA Receptors
MOA
Antagonist
GABA Receptor antagonist
Solubility
Benzene, chloroform, ethyl acetate, sparingly in alcohol and ether, practically not in water
Source data
