General
Preferred name
tauroursodeoxycholic acid
Synonyms
Tauroursodeoxycholate dihydrate ()
TUDCA dihydrate ()
UR 906 dihydrate ()
Taurolite dihydrate ()
Taurolite ()
UR 906 ()
TAUROURSODEOXYCHOLATE ()
TUDCA ()
ursodeoxycholyltaurine ()
Tauroursodeoxycholic acid sodium salt ()
Sodium tauroursodeoxycholate ()
Tauroursodeoxycholate Sodium ()
TUDC ()
Sodium Tauroursodeoxycholate (TUDC) ()
TAURURSODIOL ()
Tauroursodeoxycholic acid (sodium) ()
TUDCA (sodium) ()
UR 906 (sodium) ()
Tauroursodeoxycholic acid (dihydrate) ()
TUDCA (dihydrate) ()
UR 906 (dihydrate) ()
Tauroursodeoxycholate (Sodium) ()
Tauroursodeoxycholate (dihydrate) ()
Tauroursodeoxycholic Acid (TUDCA) ()
Ursodoxicoltaurine ()
Ursodeoxy Cholic Acid ()
Tauroursodesoxycholic acid ()
Tauroursodeoxycholic acid ()
Ur-906 ()
Tauroursodeoxycholic Acid (sodium salt hydrate) ()
Tauroursodeoxycholic Acid MaxSpec? Standard ()
Tauroursodeoxycholic Acid-d4 (sodium salt) ()
Tauroursodeoxycholic Acid-d4 MaxSpec? Standard ()
Tauro-d4-ursodeoxycholic Acid ()
P&D ID
PD016227
CAS
14605-22-2
35807-85-3
117609-50-4
2410279-95-5
2410279-94-4
2573035-17-1
Tags
available
drug
Approved by
FDA
First approval
2022
Drug indication
Discovery agent
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Tauroursodeoxycholic acid is the more hydrophilic form of ursodeoxycholic acid, which is naturally produced in the body. In patients with properly functioning gallbladders, both of these bile acids inhibit liver cholesterol secretion and synthesis as well as intestinal cholesterol absorption allowing for the promotion of cholesterol gallstone dissolution. The mechanism of action of tauroursodeoxycholic acid in the other conditions is still being investigated.; ;
DESCRIPTION Tauroursodeoxycholic acid (TUDCA) is a conjugated bile acid derivative. Evidence suggests that it acts as a chemical chaperone and facilitates protein folding within the endoplasmic reticulum . (GtoPdb)
Cell lines
0
Organisms
1
Compound Sets
18
Cayman Chemical Bioactives
20277
31605
31564
32985
9003379
39851
ChEMBL Approved Drugs
CHEMBL272427
ChEMBL Drugs
CHEMBL272427
Concise Guide to Pharmacology 2017/18
4746
Concise Guide to Pharmacology 2019/20
4746
Concise Guide to Pharmacology 2021/22
4746
Concise Guide to Pharmacology 2023/24
4746
Drug Repurposing Hub
DrugBank
DB08834
DrugBank Approved Drugs
DB08834
DrugCentral
5679
DrugCentral Approved Drugs
5679
DrugMAP
DMFKRQE
Guide to Pharmacology
4746
MedChem Express Bioactive Compound Library
HY-19696A
HY-19696
HY-19696B
Other bioactive compounds
Selleckchem Bioactive Compound Library
sodium-tauroursodeoxycholate-tudc
tauroursodeoxycholic-acid
TargetMol Bioactive Compound Library
T6993
T2532
External IDs
74
Properties
(calculated by RDKit )
Molecular Weight
499.3
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
4
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
0
cLogP
3.4
TPSA
123.93
Fraction CSP3
0.96
Chiral centers
10.0
Largest ring
6.0
QED
0.4
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Apoptosis
MAPK
Stem Cells
MAPK/ERK Pathway
Metabolic Enzyme/Protease
Stem Cell/Wnt
Target
CYP3A
Caspase
ERK
Endogenous Metabolite
Mitochondrial Metabolism
Anti-infection
MOA
cholesterol inhibitor
Source data