General
Preferred name
SDZ WAG 994
Synonyms
SDZ-WAG 994 ()
SDZ-WAG-994 ()
P&D ID
PD016929
CAS
130714-47-5
Tags
available
drug candidate
Drug indication
Hypertension
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent, selective A1 agonist
(Tocriscreen Plus)
DESCRIPTION
alpha2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent, selective A1 agonist
(Tocriscreen Total)
DESCRIPTION
SDZ WAG 994 is a potent and selective adenosine A1 receptor agonist (Ki = 23, > 10000 and 25000 nM for A1, A2A and A2B receptors, respectively). SDZ WAG 994 has been shown to lower blood pressure levels and heart rate in spontaneous hypertensive rats, and inhibit adenosine deaminase-stimulated lipolysis in rat adipocytes (Ki = 8 nM).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
9
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Drug Repurposing Hub
DrugMAP
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
363.19
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
2
cLogP
0.84
TPSA
114.55
Fraction CSP3
0.71
Chiral centers
4.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Primary Target
Adenosine A1 Receptors
MOA
Agonist
Adenosine A1 Agonists
ADORA1 agonist
Adenosine Receptor agonist
Member status
member
Target
ADORA1
a1 agonist
Source data
