General
Preferred name
E-3174
Synonyms
Losartan (D4 Carboxylic Acid) ()
E-3174 D4 ()
EXP-3174 D4 ()
EXP-3174 ()
E 3174 ()
EXP3174 ()
Losartan Carboxylic Acid ()
EXP 3174 ()
Carboxylosartan ()
Losartan Carboxylic Acid (EXP-3174) ()
CARBOXYLIC ACID METABOLITE ()
P&D ID
PD018082
CAS
124750-92-1
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Potent and selective V1B receptor antagonist; orally bioavailable (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
12
Cayman Chemical Bioactives
15957
Concise Guide to Pharmacology 2017/18
586
Drug Repurposing Hub
DrugMAP
DMWIBFM
Guide to Pharmacology
586
Ki Database
E 3174
EXP3174
MedChem Express Bioactive Compound Library
HY-12765
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
losartan-carboxylic-acid-exp-3174-
TargetMol Bioactive Compound Library
T3461
Tocris Bioactive Compound Library
5728
External IDs
39
Properties
(calculated by RDKit )
Molecular Weight
436.14
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
4
cLogP
4.47
TPSA
109.58
Fraction CSP3
0.23
Chiral centers
0.0
Largest ring
6.0
QED
0.42
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Angiotensin Receptor
AT1 receptor
AGTR1
Drug Metabolite
Pathway
GPCR/G protein
Endocrinology/Hormones
Metabolic Enzyme/Protease
Primary Target
Angiotensin AT1 Receptors
MOA
Antagonist
angiotensin antagonist
Source data