General
Preferred name
Linoleoyl Ethanolamide
Synonyms
N-(2-hydroxyethyl)linoleoylamide ()
Linoleoyl Ethanolamide-d4 ()
LINOLEOYLETHANOLAMIDE ()
P&D ID
PD020554
CAS
68171-52-8
1451194-69-6
Tags
available
drug candidate
natural product
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Linoleoyl ethanolamide is an endocannabinoid with weak affinity for CB1 and CB2 receptors. In mouse RAW264.7 macrophages, linoleoyl ethanolamide inhibited NF-κB signaling and exhibited potent anti-inflammatory effects, suggesting that it has the potential for the treatment of contact dermatitis.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
4
BOC Sciences Bioactive Compounds
DrugMAP
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
323.28
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
16
Ring Count
0
Aromatic Ring Count
0
cLogP
4.91
TPSA
49.33
Fraction CSP3
0.75
Chiral centers
0.0
Largest ring
0.0
QED
0.31
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Target
TRPV1
Solubility
water, 0.108 mg/L @ 25 °C (est)
Source data
