General
Preferred name
Quinazolin-4-ol
Synonyms
4-HQN ()
4(3H)-Quinazolinone ()
4-Quinazolinol ()
4-Quinazolinone ()
4-Quinazolone ()
4-Hydroxyquinazoline ()
3,4-dihydroquinazolin-4-one ()
Quinazolin-4-ol, 4-Quinazolinol ()
QUINAZOLINONE ()
P&D ID
PD021738
CAS
491-36-1
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PARP inhibitor
(Tocriscreen Total)
DESCRIPTION
4-HQN is a poly(ADP-ribose) polymerase (PARP) inhibitor (IC50 = 9.5 μM). 4-HQN exhibits antianti-ischemic activity and reduces ROS production, subsequent mitochondrial and cell damage in rat heart. It also blocks NF-κB and AP-1 activation.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
146.05
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
1.34
TPSA
46.01
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antiplatelet
PARP1
Bacterial
EGFR
PARP
MOA
PARP inhibitor
Pathway
Anti-infection
JAK/STAT Signaling
Protein Tyrosine Kinase/RTK
Source data
