General
Preferred name
ZACOPRIDE HYDROCHLORIDE
Synonyms
Zacopride HCl ()
AHR-11190-B ()
Zacopride (hydrochloride) ()
P&D ID
PD021798
CAS
101303-98-4
99617-34-2
Tags
available
Drug indication
Stimulant (peristaltic)
Anti-Emetic
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist (Tocriscreen Plus)
DESCRIPTION KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr) (Tocris Bioactive Compound Library)
DESCRIPTION Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist (Tocriscreen Total)
DESCRIPTION Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist (Ki = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). Zacopride hydrochloride acts as an antiemetic and anxiolytic following systemic administration in vivo. (BOC Sciences Bioactive Compounds)
Compound Sets
7
BOC Sciences Bioactive Compounds
zacopride-hydrochloride-cas-101303-98-4-357688
CZ-OPENSCREEN Bioactive Library
MedChem Express Bioactive Compound Library
HY-103137
TargetMol Bioactive Compound Library
T5336
Tocris Bioactive Compound Library
1795
Tocriscreen Plus
1795
Tocriscreen Total
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
345.1
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
1
cLogP
2.18
TPSA
67.59
Fraction CSP3
0.53
Chiral centers
1.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Pathway
GPCR/G protein
Membrane Transporter/Ion Channel
Neuroscience
Neuronal Signaling
Target
5-HT3 antagonist
5-HT4 agonist
IK1/Kir2.1 agonist
Primary Target
5-HT3 Receptors
MOA
Antagonist
5-HT Receptor
Potassium Channel
Source data