General
Preferred name
Norclozapine
Synonyms
N-DESMETHYLCLOZAPINE ()
Desmethylclozapine ()
Normethylclozapine ()
N-Demethylclozapine ()
N-Desmethylclozapine-d8 ()
P&D ID
PD021872
CAS
6104-71-8
1189888-77-4
Tags
available
drug candidate
Drug indication
Schizoaffective disorder
Schizophrenia
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 5-HT2C antagonist (Tocriscreen Total)
Compound Sets
9
Axon Medchem Screening Library
2846
Cayman Chemical Bioactives
26153
26027
Drug Repurposing Hub
DrugBank
DB05766
DrugMAP
DMVIRN3
MedChem Express Bioactive Compound Library
HY-G0021
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T5158
Tocriscreen Total
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
312.11
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
3.38
TPSA
39.66
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
7.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Endocrinology/Hormones
Anti-infection
Metabolic Enzyme/Protease
Neuronal Signaling
Target
5-HT2C
D4
??-opioid receptor
¦Ä-opioid receptor
HTR2C
Clozapine metabolite
Drug Metabolite
mAChR
Opioid Receptor
Virus Protease
MOA
5-HT Receptor antagonist
Dopamine Receptor antagonist
Opioid Receptor agonist
Muscarinic M1 Agonists
5-HT2A Inverse Agonists
Dopamine D3 Partial Agonists
Dopamine D2 Receptor Partial Agonists
acetylcholine receptor agonist
Member status
member
Source data