General
Preferred name
Anpirtoline hydrochloride
Synonyms
Anpirtoline (hydrochloride) ()
D-16949 (hydrochloride) ()
P&D ID
PD022023
CAS
99201-87-3
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Highly potent 5-HT1B agonist. Also 5-HT3 antagonist
(Tocriscreen Plus)
DESCRIPTION
Dopamine agonist (D3 greater than or equal to D2 < > D4)
(Tocris Bioactive Compound Library)
DESCRIPTION
Highly potent 5-HT1B agonist. Also 5-HT3 antagonist
(Tocriscreen Total)
DESCRIPTION
Anpirtoline hydrochloride is the hydrochloride salt of anpirtoline, which is a highly potent 5-HT1B receptor agonist with Ki values of 28 nM. It decreases central serotonin synthesis and attenuates aggressive behavior in vivo. It also acts as an antagonist at 5-HT3 receptors with Ki value of 29.5 nM and is brain penetrant. It is a receptor agonist with antinociceptive/antidepressant-like actions in rodents.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
BOC Sciences Bioactive Compounds
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
11
Molecular Weight
264.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
3.0
TPSA
24.92
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Primary Target
5-HT1B Receptors
MOA
Agonist
Pathway
GPCR/G protein
Neuronal Signaling
Target
5-HT Receptor
Source data
