General
Preferred name
oleandrin
Synonyms
Folinerin ()
Foliandrin ()
Neriostene ()
PBI-05204 ()
Oleandrin (PBI-05204) ()
Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol ()
NSC-692219 ()
Anvirzel ()
P&D ID
PD040549
CAS
465-16-7
Tags
available
natural product
drug
Drug indication
Solid tumour/cancer
Pancreatic cancer
Drug Status
experimental
approved
investigational
Max Phase
1.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Oleandrin is a plant-derived glycoside. It has been associated with a range of biological effects in animals , including potential anti-tumour activity . Inhibition of FGF-2 export from prostate cancer cells has been reported, and this is proposed as a potential mechanism underlying its anti-tumour effect .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
8
Organisms
0
Compound Sets
12
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
576.33
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
6
Aromatic Ring Count
0
cLogP
3.68
TPSA
120.75
Fraction CSP3
0.88
Chiral centers
13.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Target
Sodium Channel
Potassium Channel
Na+/K+ ATPase
ATPase
MOA
Na/K-ATPase inhibitor
Source data
