General
Preferred name
Glycyl-H 1152
Synonyms
Glycyl-H 1152 dihydrochloride ()
Rho kinase inhibitor IV ()
(S)-Glycyl-H-1152 (hydrochloride) ()
P&D ID
PD048364
CAS
913844-45-8
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION This is compound 18 in . It is a selective and potent Rho kinase inhibitor (GtoPdb)
DESCRIPTION Potent fatty acid synthase inhibitor; proapoptotic (Tocris Bioactive Compound Library)
DESCRIPTION Glycyl-H 1152 dihydrochloride is a glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride with an improved selectivity for ROCKII (IC50 = 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC, respectively). Glycyl-H 1152 dihydrochloride is used for the treatment of hypertension and arteriosclerosis. (BOC Sciences Bioactive Compounds)
Compound Sets
6
BOC Sciences Bioactive Compounds
glycyl-h-1152-dihydrochloride-cas-913844-45-8-item-119992
Cayman Chemical Bioactives
13332
CZ-OPENSCREEN Bioactive Library
DrugMAP
DM0SCK8
Guide to Pharmacology
6033
Tocris Bioactive Compound Library
2485
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
376.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
1.11
TPSA
96.6
Fraction CSP3
0.44
Chiral centers
1.0
Largest ring
7.0
QED
0.87
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Rho-Kinases
MOA
Inhibitor
Source data