General
Preferred name
ecopipam
Synonyms
SCH 39166 hydrobromide ()
SCH 39166 (hydrochloride) ()
Ecopipam (hydrochloride) ()
SCH 39166 (hydrobromide) ()
SCH-39166 ()
Ecopipam hcl ()
SCH 39166 ()
ECOPIPAM HYDROCHLORIDE ()
P&D ID
PD049447
CAS
1227675-51-5
112108-01-7
125652-14-4
190133-94-9
Tags
natural product
drug candidate
available
Drug indication
Tourette syndrome
Cocaine addiction
Drug Status
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ecopipam, a synthetic benzazepine derivative drug, acts as a selective dopamine D1/D5 receptor antagonist with little affinity for either dopamine D2-like or 5-HT2 receptors. It was developed by Schering plough. It is currently in clinical trials conducted by the biotechnology company Psyadon Pharmaceuticals for the treatment of Tourette syndrome in children. It has received FDA treatment of Lesch-Nyhan disease orphan drug certification.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Selective, orally active CCK1 receptor antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
SCH 39166 hydrobromide is a high affinity dopamine D1/D5 receptor antagonist (Ki = 1.2, 2, 980, 5520, 80 and 731 nM for binding to D1, D5, D2, D4, 5-HT and α2a receptors, respectively). SCH 39166 is used in the treatment of schizophrenia, cocaine addiction and obesity.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugMAP
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
47
Molecular Weight
313.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
3.98
TPSA
23.47
Fraction CSP3
0.37
Chiral centers
2.0
Largest ring
7.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
D1 and D5 Receptors
MOA
Antagonist
selective dopamine D1/D5 receptor antagonist
Member status
member
Pathway
GPCR/G protein
Neuronal Signaling
Target
5-HT Receptor
Adrenergic Receptor
Dopamine Receptor
Solubility
10 mM in DMSO
Source data
