General
Preferred name
LORMETAZEPAM
Synonyms
WY-4082 ()
Loramet ()
Methyllorazepam ()
Chlorotemazepam ()
P&D ID
PD049470
CAS
848-75-9
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Sedative-Hypnotic
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY The primary manifestation of overdosage ranges from drowsiness to coma and symptoms may include ataxia, hypotension, hypotonia, respiratory depression which may lead to death [L927].; ; Experimental LD50 values are as follows [L928]: Mouse - 780 mg/kg (intraperitoneal), 1790 mg/kg (oral), 10000 mg/kg (subcutaneous). Rat - 6250 mg/kg (intraperitoneal), 10000 mg/kg (oral), 10000 mg/kg (intraperitoneal).
Compound Sets
10
Cayman Chemical Bioactives
21989
ChEMBL Approved Drugs
CHEMBL22097
ChEMBL Drugs
CHEMBL22097
DrugBank
DB13872
DrugBank Approved Drugs
DB13872
DrugCentral
1608
DrugCentral Approved Drugs
1608
DrugMatrix
Guide to Pharmacology
7553
ReFrame library
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
334.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
3.13
TPSA
52.9
Fraction CSP3
0.12
Chiral centers
1.0
Largest ring
7.0
QED
0.87
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data