General
Preferred name
JNJ-39758979
Synonyms
JNJ 39758979 dihydrochloride ()
JNJ-39758979 dihydrochloride ()
JNJ-39758979, (-)- ()
JNJ39758979 ()
Jnj 39758979 ()
JNJ_39758979 ()
JNJ 39758979 ()
P&D ID
PD050062
CAS
1046447-90-8
1620648-30-7
Tags
available
free of charge
probe
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
Asthma
Probe info
Probe type
P&D approved
experimental probe
Probe selectivity
protein-selective
Probe sources
Chemical Probes.org
High-quality chemical probes
Open Science Probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION JNJ-39758979 is a selective histamine H4 receptor antagonist with anti-inflammatory potential. (GtoPdb)
DESCRIPTION JNJ-39758979 is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity[1][2].
PRICE 149
MOA Antagonist (Chemical Probes.org)
DESCRIPTION JNJ-39758979 is a selective and high-affinity histamine H4 receptor antagonist (Kis: 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively). JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. (TargetMol Bioactive Compound Library)
DESCRIPTION GPR171 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION JNJ-39758979 is a potent and selective histamine H4 antagonist (Ki = 12.5 nM) with >80-fold selectivity for H4 over other histamine receptors. It was shown to inhibit histamine-induced pruritus in healthy subjects. (BOC Sciences Bioactive Compounds)
Compound Sets
19
BOC Sciences Bioactive Compounds
jnj-39758979-dihydrochloride-cas-1620648-30-7-291241
Cayman Chemical Bioactives
41084
ChEMBL Drugs
CHEMBL3236549
Chemical Probes.org
jnj-39758979
Concise Guide to Pharmacology 2017/18
8984
Concise Guide to Pharmacology 2019/20
8984
Concise Guide to Pharmacology 2021/22
8984
Concise Guide to Pharmacology 2023/24
8984
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB18899
EUbOPEN Chemogenomics Library
CHEMBL3236549
Guide to Pharmacology
8984
High-quality chemical probes
PD050062
MedChem Express Bioactive Compound Library
HY-101189
Open Science Probes
JNJ-39758979
ReFrame library
TargetMol Bioactive Compound Library
T11723L
Tocris Bioactive Compound Library
6279
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
221.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
0.72
TPSA
81.06
Fraction CSP3
0.64
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Primary Target
Histamine H4 Receptors
MOA
Antagonist
Histamine Receptor antagonist
Control name
JNJ-39668551
Target
HRH4
H4 receptor
Target class
GPCR
Target subclass
Histamine Receptor
Recommended Cell Concentration
10 uM
Source data