General
Preferred name
RESINIFERATOXIN
Synonyms
(+)-Resiniferatoxin ()
Lopain ()
Neuroclastin ()
MTX-71 ()
Mtx-071 ()
RTX ()
P&D ID
PD050559
CAS
57444-62-9
Tags
available
natural product
drug candidate
Drug indication
Pain
Neuropathic pain
Cancer related pain
Osteoarthritis
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION Investigated for use/treatment in interstitial cystitis and urinary incontinence.
DESCRIPTION Resiniferatoxin, an extract from resin spurge (Euphorbia resinifera), is a TRPV1 agonist.
There is some ambiguity online and in the literature as to the exact stereochemistry of resiniferatoxin. The representation shown here matches that in the PubChem and ChEMBL links above, while several tautomers and stereoisomers are also listed on PubChem, and ChEBI represents the compound with the entry CHEBI:8809. (GtoPdb)
Cell lines
0
Organisms
3
Compound Sets
9
ChEMBL Drugs
CHEMBL17976
Concise Guide to Pharmacology 2017/18
4091
2491
Concise Guide to Pharmacology 2019/20
4091
2491
Concise Guide to Pharmacology 2021/22
4091
2491
Concise Guide to Pharmacology 2023/24
4091
2491
DrugBank
DB06515
DrugMAP
DMP62L5
Guide to Pharmacology
4091
2491
MedChem Express Bioactive Compound Library
HY-N2333
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
628.27
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
7
Aromatic Ring Count
2
cLogP
4.74
TPSA
120.75
Fraction CSP3
0.46
Chiral centers
8.0
Largest ring
7.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Analgesics
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
TRP Channel
Source data