General
Preferred name
WR-1065
Synonyms
WR-1065 (dihydrochloride) ()
WR 1065 dihydrochloride ()
Amifostine thiol (dihydrochloride) ()
Amifostine thiol ()
WR 1065 ()
Amifostine thiol (hydrochloride) ()
NSC-647527 ()
P&D ID
PD053955
CAS
31098-42-7
14653-77-1
Tags
covalent binder
natural product
drug candidate
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Restores mutant p53 activity; proapoptotic
(Tocris Bioactive Compound Library)
DESCRIPTION
WR 1065 is a metabolite of Amifostine, and a cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. WR 1065 activates p21waf-1 and MDM2 and inhibits DNA topoisomerase IIα. WR 1065 can induce cell cycle arrest and exert cytoprotective activity towards normal cells but not cancer cells in vivo.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
CovBinderInPDB
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
134.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.15
TPSA
38.05
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.36
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
p53
MOA
Activator
Pathway
Apoptosis
Target
MDM-2/p53
Source data
