General
Preferred name
Protopine
Synonyms
Corydinine ()
Fumarine ()
Biflorine ()
Macleyine ()
Hypercorine ()
Corydinine, Fumarine, Biflorine, Macleyine ()
Protopine (hydrochloride) ()
Protopine HCl ()
PROTOPINE HYDROCHLORIDE ()
P&D ID
PD056637
CAS
130-86-9
6164-47-2
Tags
available
natural product
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Cell lines
1
Organisms
0
Compound Sets
6
AdooQ Bioactive Compound Library
A14808
Cayman Chemical Bioactives
23366
MedChem Express Bioactive Compound Library
HY-N0793
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
protopine
TargetMol Bioactive Compound Library
T3429
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
353.13
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
5
Aromatic Ring Count
2
cLogP
2.56
TPSA
57.23
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
10.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Target
H1 receptor
Platelet aggregation
Cholinesterase (ChE)
ADC Cytotoxin,Calcium Channel
Member status
member
MOA
Acetylcholinesterase Inhibitors
Norepinephrine Transporter (NET) Inhibitors
Serotonin Transporter (SERT) Inhibitors
Inhibits LPS induced cytokine secretion
Source data