General
Preferred name
RABACFOSADINE
Synonyms
GS-9219 ()
VDC-1101 ()
GS-9219-01 ()
Gs-9219 succinate ()
Vdc-1101 succinate ()
VDC-1101-01 ()
RABACFOSADINE SUCCINATE ()
P&D ID
PD058776
CAS
859209-74-8
Tags
drug candidate
natural product
available
Approved by
FDA
Drug indication
Solid tumour/cancer
Drug Status
vet_approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
GS-9219 is a prodrug of the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)guanine (PMEG) with potential antineoplastic activity. Formulated to selectively accumulate in lymphocytes, nucleotide analogue GS 9219 is converted to its active metabolite, PMEG diphosphate (PMEGpp), via enzymatic hydrolysis, deamination, and phosphorylation; subsequently, PMEGpp is incorporated into nascent DNA chains by DNA polymerases, which may result in the termination of DNA synthesis, S-phase cell cycle arrest, and the induction of apoptosis in susceptible lymphoma cell populations.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
0
Compound Sets
7
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugCentral
DrugMAP
MedChem Express Bioactive Compound Library
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
526.24
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
4
Rotatable Bonds
15
Ring Count
3
Aromatic Ring Count
2
cLogP
1.23
TPSA
184.61
Fraction CSP3
0.67
Chiral centers
2.0
Largest ring
6.0
QED
0.15
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Cell Cycle/DNA Damage
Target
Nucleoside antimetabolite/analog
Source data
