General
Preferred name
SKF 77434
Synonyms
(±)-SKF 38393, N-allyl-, hydrobromide ()
SKF 77434 hydrobromide ()
SKF 77434 (hydrobromide) ()
N-Allyl-(±)-SKF 38393 (hydrobromide) ()
P&D ID
PD062227
CAS
300561-58-4
104422-04-0
Tags
natural product
biased GPCR ligand
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
D1 dopamine receptor agonist.
(LOPAC library)
DESCRIPTION
Potent, selective non-peptide delta agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective D1-like partial agonist
(Tocriscreen Total)
DESCRIPTION
SKF 77434 hydrobromide is a selective dopamine D1-like receptor partial agonist (IC50 = 19.7 and 2425 nM for binding to D1-like and D2-like receptors, respectively).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
9
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
295.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
3.27
TPSA
43.7
Fraction CSP3
0.26
Chiral centers
1.0
Largest ring
7.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D1
Primary Target
D1 and D5 Receptors
MOA
Agonist
Pathway
GPCR/G protein
Neuronal Signaling
Target
Dopamine Receptor
Source data
