General
Preferred name
VERUBULIN
Synonyms
MPC-6827 (hydrochloride) ()
MPC 6827 hydrochloride ()
MPC-6827 hydrochloride ()
VERUBULIN HYDROCHLORIDE ()
MPC 6827 ()
Verubulin (hydrochloride) ()
Verubulin hcl ()
MPC-6827 ()
Azixa ()
MX-128495 ()
Verubuline ()
Verubulina ()
P&D ID
PD069497
CAS
917369-31-4
827031-83-4
Tags
available
drug candidate
Drug indication
Brain metastases
Solid tumour/cancer
Recurrent glioblastoma
Glioblastoma multiforme
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
High affinity and selective HIF-2alpha inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Inhibitor of microtubule polymerization; antimitotic and antitumor
(Tocriscreen Plus)
DESCRIPTION
Verubulin, also known as MPC-6827, is quinazoline derivative with potential dual antineoplastic activities. Verubulin hydrochloride binds to and inhibits tubulin polymerization and interrupts microtubule formation, resulting in disruption of mitotic spindle assembly, cell cycle arrest in the G2/M phase, and cell death. This agent is not a substrate for several subtypes of multidrug resistance ABC transporters, such as P-glycoprotein, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1); therefore, it may be useful for treating multidrug resistant (MDR) tumors that express these transporters. In addition, as a vascular disrupting agent (VDA), MPC-6827 appears to disrupt tumor microvasculature specifically, which may result in acute ischemia and massive tumor cell death.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
21
Organisms
0
Compound Sets
12
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
279.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
3.71
TPSA
38.25
Fraction CSP3
0.18
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Pathway
Cytoskeletal Signaling
Cell Cycle/DNA Damage
cytoskeleton
Apoptosis
Target
Microtubule
TUBB
Microtubule/Tubulin
Microtubule Associated
Primary Target
Microtubules
MOA
tubulin polymerization inhibitor
Source data
