General
Preferred name
ZOSUQUIDAR
Synonyms
ZOSUQUIDAR TRIHYDROCHLORIDE ()
LY335979 ()
LY-335979 trihydrochloride ()
RS 33295-198 trihydrochloride ()
Zosuquidar (LY335979) 3HCl ()
RS 33295-198 (D06387) 3HCl ()
Zosuquidar 3HCl ()
RS 33295-198 ()
LY-335979 ()
Zosuquidar (trihydrochloride) ()
NSC-725086 ()
Zosuquidar (hydrochloride) ()
P&D ID
PD069682
CAS
167465-36-3
167354-41-8
Tags
available
drug candidate
Drug Status
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION
Investigated for use/treatment in leukemia (myeloid) and myelodysplastic syndrome.
MOA
P-glycoproteins are proteins which convert the energy derived from the hydrolysis of ATP to structural changes in protein molecules, in order to perform coupling, thus discharging medicine from cells. If P-glycoprotein coded with the MDR1 gene manifests itself in cancer cells, it discharges much of the antineoplastic drugs from the cells, making cancer cells medicine tolerant, and rendering antineoplastic drugs ineffective. This protein also manifests itself in normal organs not affected by the cancer (such as the liver, small intestine, and skin cells in blood vessels of the brain), and participates in the transportation of medicine. The compound Zosuquidar inhibits this P-glycoprotein, causing the cancer cells to lose their medicine tolerance, and making antineoplastic drugs effective.
DESCRIPTION
Antibiotic
(Tocris Bioactive Compound Library)
DESCRIPTION
High affinity P-gp inhibitor
(Tocriscreen Plus)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
11
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
LSP-MoA library (Laboratory of Systems Pharmacology)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
527.24
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
7
Aromatic Ring Count
4
cLogP
5.21
TPSA
48.83
Fraction CSP3
0.34
Chiral centers
4.0
Largest ring
7.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Transporters
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Target
P-gp?(P-glycoprotein)
ABCB1, ABCB4
P-glycoprotein
P-gp
Primary Target
Multidrug Transporters
MOA
Inhibitor
P glycoprotein inhibitor
Source data
