General
Preferred name
SIB-1508Y
Synonyms
SIB 1508Y maleate ()
Altinicline maleate ()
SIB-1765F ()
(-)-5-ethynylnicotine ()
ALTINICLINE ()
P&D ID
PD069712
CAS
192231-16-6
179120-92-4
Tags
available
drug candidate
Drug indication
Parkinson disease
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Selective KV7.1 (KCNQ1) potassium channel activator; augments IKs current
(Tocris Bioactive Compound Library)
DESCRIPTION
SIB 1508Y maleate is a potent neuronal nicotinic acetylcholine receptor (nAChR) agonist (EC50 = 1.8, 5, 9 and 23 nM for α4β2, α2β4, α4β4 and α3β4 receptors, respectively). SIB 1508Y has been shown to increase dopamine release and exhibit antidepressant activity. SIB 1508Y is used for the treatment of Parkinson's disease.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugMAP
ReFrame library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
186.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
1.83
TPSA
16.13
Fraction CSP3
0.42
Chiral centers
1.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Nicotinic Receptors (Non-selective)
MOA
Agonist
nicotinic receptor agonist
Target
CHRNA4, CHRNB2
Source data
