General
Preferred name
CGH 2466 dihydrochloride
Synonyms
P&D ID
PD070580
CAS
252198-68-8
1177618-54-0
Tags
natural product
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
A1, A2B and A3 antagonist and inhibitor of p38 MAPK and PDE4
(Tocriscreen Total)
DESCRIPTION
CGH 2466 dihydrochloride is an adenosine A1, A2B and A3 receptor antagonist (IC50 = 19, 21, and 80 nM, respectively). It also displays an inhibitory effect on p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). CGH 2466 is potentially used for the treatment of asthma and chronic obstructive pulmonary disease (COPD).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
BOC Sciences Bioactive Compounds
Drug Repurposing Hub
Novartis Chemogenetic Library (NIBR MoA Box)
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
320.99
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
4.76
TPSA
51.8
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
Adenosine A1 Antagonists
Adenosine A2B Antagonists
Adenosine A3 Antagonists
Phosphodiesterase IV Inhibitors
p38 MAPK Inhibitors
Adenosine Receptor antagonist
Target
ADORA1, ADORA2B, ADORA3
Source data
