General
Preferred name
GSK481
Synonyms
GSK'481 ()
5-benzyl-N-[(3S)-5-methyl-4-oxo-2 ()
3-dihydro-1 ()
5-benzoxazepin-3-yl]-1 ()
2-oxazole-3-carboxamide ()
P&D ID
PD071437
CAS
1622849-58-4
Tags
available
probe
Probe info
Probe selectivity
protein-selective
Probe type
experimental probe
P&D approved
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
3
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
COMMENT
GSK481 is a remarkably potent and selective inhibitor of RIPK1 that is suitable to interrogate this target in cells. On the other hand, it may not be suitable for in vivo use, as RIPK1 orthologs show significant divergence between primates and nonprimates that can lead to large binding differences for type I inhibitors like GSK481. Indeed, relative to the human and monkey RIPK1 orthologs, the affinity of GSK481 was at least 100x weaker in binding assays for rat, minipig, dog, rabbit and mouse orthologs of RIPK1. Mar 9 2017 - 1:35pm; Despite being highly selective and potent, GSK481 should only be used as chemical probe in cells. Mar 17 2017 - 3:34pm
MOA
Inhibitor
(Chemical Probes.org)
DESCRIPTION
GSK481 is a potent inhibitor of Receptor-interacting serine/threonine-protein kinase 1 (RIPK1 or RIP1; IC50 value 2.8 nM for inhibition of Ser166 autophosphorylation of hWT RIP1) with preference for RIP1 over 450 other kinases.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
14
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Chemical Probes.org
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
CZ-OPENSCREEN Bioactive Library
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
High-quality chemical probes
Kinase Chemogenomic Set (KCGS)
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
12
Molecular Weight
377.14
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
2.42
TPSA
84.67
Fraction CSP3
0.19
Chiral centers
1.0
Largest ring
7.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Apoptosis
Target
RIP1
RIPK1
RIP1 kinase inhibitor
RIP Kinase
Target class
Protein kinase
Kinase
Orthogonal probe
GSK2982772
Target subclass
TKL
Control
5-benzyl-N-[(3R)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide
Recommended Cell Concentration
None
Source data
