General
Preferred name
PRX-07034
Synonyms
PRX 07034 ()
PRX-07034 (hydrochloride) ()
PRX-07034 hydrochloride ()
P&D ID
PD077628
CAS
903580-39-2
Tags
natural product
drug candidate
available
Drug indication
Obesity
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA PRX-07034 is a novel, highly selective, small-molecule antagonist of a specific G-protein coupled receptor (GPCR) known as 5-HT6 being developed for the treatment of obesity, Alzheimer's disease and cognitive impairment associated with schizophrenia.; ; PRX-07034 has also been shown to enhance cognitive function in preclinical animal models of memory impairment through a dual mechanism of action.It has an effect on both the acetylcholine and glutamate neurotransmitter systems in the brain, which makes it a potentially complementary therapy to cholinesterase inhibitors, a class of drugs approved for the treatment of Alzheimer's disease.;
DESCRIPTION Potent and selective CB1 receptor antagonist (Tocris Bioactive Compound Library)
DESCRIPTION PRX-07034 is a potent and selective 5-HT6 receptor antagonist. It was shown to improve cognition and memory in rats. (BOC Sciences Bioactive Compounds)
Compound Sets
7
BOC Sciences Bioactive Compounds
prx-07034-cas-903580-39-2-item-283731
DrugBank
DB05993
DrugMAP
DM5TLAP
MedChem Express Bioactive Compound Library
HY-14559
ReFrame library
TargetMol Bioactive Compound Library
T8720
Tocris Bioactive Compound Library
6748
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
453.15
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
3.34
TPSA
79.9
Fraction CSP3
0.43
Chiral centers
1.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
5-HT6
5-HT Receptor
Primary Target
5-HT6 Receptors
MOA
Antagonist
Source data