General
Preferred name
paxalisib
Synonyms
GDC 0084 ()
GDC-0084 ()
RG7666 ()
GDC0084 ()
G-02441729 ()
G02441729 ()
RG-7666 ()
Paxalisib (GDC-0084) ()
P&D ID
PD078344
CAS
1382979-44-3
Tags
available
drug candidate
Drug indication
Glioblastoma of brain
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Paxalisib (GDC0084) is a dual PI3K/mTOR inhibitor that was developed by Genentech . It was designed to cross the blood-brain-barrier as a potential oncology drug for the treatment of malignant gliomas. (GtoPdb)
Compound Sets
10
ChEMBL Drugs
CHEMBL3813842
Drug Repurposing Hub
DrugBank
DB15186
DrugMAP
DMA9SEY
Guide to Pharmacology
10097
MedChem Express Bioactive Compound Library
HY-19962
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
gdc-0084
TargetMol Bioactive Compound Library
T3705
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
382.19
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
5
Aromatic Ring Count
3
cLogP
0.97
TPSA
117.1
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
PI3K/Akt/mTOR signaling
PI3K/Akt/mTOR
Target
MTOR
PI3K??
PI3K¦Á
PI3K¦Â
PI3K¦Ã
PI3K¦Ä
PI3K
mTOR,PI3K
MOA
mTOR inhibitor, PI3K inhibitor
Source data