General
Preferred name
MOZ-IN-3
Synonyms
WM-8014 ()
WM 8014 ()
P&D ID
PD087022
CAS
2055397-18-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Highly potent and selective GSK-3 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION MOZ-IN-3 is a highly potent and selective inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) with IC50 value of 8 nM. It also inhibits KAT6B/MORF with IC50 value of 28 nM. MOZ-IN-3 induced cell cycle arrest in and inhibited proliferation of mouse embryonic fibroblasts (IC50 = 2.4 µM), and induced cellular senescence without causing DNA damage or displaying a general cytotoxicity effect in mouse lymphoma cells. (BOC Sciences Bioactive Compounds)
Compound Sets
8
BOC Sciences Bioactive Compounds
moz-in-3-cas-2055397-18-5-291443
Cayman Chemical Bioactives
27402
Mcule NIBR MoA Box Subset
MCULE-7134953685
MedChem Express Bioactive Compound Library
HY-102060
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
wm-8014
TargetMol Bioactive Compound Library
T4362
Tocris Bioactive Compound Library
6693
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
384.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
3.42
TPSA
75.27
Fraction CSP3
0.05
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Chromatin/Epigenetic
Epigenetics
Target
MOZ
Histone Acetyltransferase
Primary Target
Histone Acetyltransferases
MOA
Inhibitor
Member status
member
Source data