General
Preferred name
GANTACURIUM
Synonyms
GANTACURIUM CHLORIDE ()
GW280430A ()
GW-280430A ()
AV-4430A ()
GW-280430 ()
Chlorure de gantacurium ()
Cloruro de gantacurio ()
Gantacurium cation ()
Gantacurium ion ()
P&D ID
PD098411
CAS
758669-50-0
213998-46-0
Tags
drug candidate
Drug indication
Anaesthesia
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
METABOLISM
The pharmacokinetic parameters are consistent with in situ rapid inactivation by plasma cysteine.
INDICATION
Investigated for use/treatment in anesthesia (unspecified).
HALF-LIFE
3.09±0.21 minutes
PHARMACODYNAMICS
Gantacurium chloride administered to anesthetized and ventilated healthy volunteers, caused dose dependent transient decrease in arterial blood pressure, mild histamine release at higher doses and no consistent changes in pulmonary compliance.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
992.44
Hydrogen Bond Acceptors
14
Hydrogen Bond Donors
0
Rotatable Bonds
23
Ring Count
6
Aromatic Ring Count
4
cLogP
7.84
TPSA
144.9
Fraction CSP3
0.47
Chiral centers
4.0
Largest ring
6.0
QED
0.03
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
