General
Preferred name
(2R/S)-6-PNG
Synonyms
6-Prenylnaringenin ()
(±)-6-Prenylnaringenin ()
P&D ID
PD117719
CAS
68682-01-9
Tags
natural product
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel activator
(Tocris Bioactive Compound Library)
DESCRIPTION
Cav3.2 (T-type) Ca2+ channel blocker (IC50 = 991 nM). Suppresses neuropathic allodynia in mouse pain models.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
4
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
340.13
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
4.02
TPSA
86.99
Fraction CSP3
0.25
Chiral centers
1.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
CaV3.x Channels (T-type)
MOA
Blocker
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
Calcium Channel
Source data
