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91
compound sets
132,750
original compounds
117,426
standardized compounds
102,789
nonisomeric compounds
12,067
targets
318,942
compound-target associations
2,865
pathways
6,303
target/pathway classes
515
structural alerts
9,412
matched structural alerts
∞
filter combinations
Probes
&
Drugs
02.2024
COMPOUNDS
APPROVED DRUGS
PROBES
PROBE
TYPES
1,307
experimental
3,670
calculated
1,139
P&D approved
849
high-quality
253
obsolete
211
free of charge
probe
P&D approved
Glucocorticoid receptor
Kinase
similar to Imatinib
nuisance compounds
The Probes & Drugs portal (P&D)
is a hub for the integration of high-quality bioactive compound sets enabling their analysis and comparison. Its main focus is on
chemical probes
and
drugs
but it also includes additional relevant sets from specialist databases/scientific publications, and vendor sets. Upon these, established bioactive chemistry sources (such as
ChEMBL
,
BindingDB
,
Guide To Pharmacology
,
DrugCentral
or
DrugBank
) are utilized for compounds' biological annotation. As of
ver. 02.2024
, the P&D compound database is composed of
91 sources
including
13 probe-related
,
12 drug compilations
,
47 academic/non-commercial sets
and
16 precompiled sets from bioactive compound vendors
.
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FAQ
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Examples of complex queries
1
What chemical probes are also approved drugs?
2
Which approved drugs bind to Glucocorticoid and Mineralocrticoid receptor with at least 1 nM potency?
3
What potent GPCR ligands are also potent Kinase ligands?
4
What chemical probes are highly-rated at the Chemical Probes Portal as well as Probes & Drugs?
5
What is the intersection of compounds in DrugBank, DrugCentral and ChEMBL Approved Drugs set?
6
What chemical probes are associated with at least one structural alert (PAINS, nuisance compounds, obsolete structure)?
7
What potent ligands of Estrogen receptor α are dissimilar to Estradiol?
8
What chemical probes are, based on available data, meeting the biochemical potency (100nM) and on target cell-based potency (1µM) criteria?
Latest news
Aug. 22, 2024
P&D 02.2024 released with all major data sources updated, new sets and updated HQCP set
The second version of the Probes & Drugs portal this year, 02.2024, was released after...
(read more)
Feb. 13, 2024
First P&D release in 2024 with the new Concise guide to pharmacology, Withdrawn DB and a glossary
The first release of the Probes & Drugs this year - 01.2024 - is here...
(read more)
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