Preferred name
LESTAURTINIB
Synonyms
CEP-701 ()
CEP-701, SP-924, KT-555, SP924, KT-5555, A-1544750, SPM-924, A-154475 ()
KT-5555 ()
A-154475 ()
A-154475.0 ()
KT-555 ()
KT5555 ()
SP-924 ()
SP924 ()
SPM-924 ()
Cep-701 ()
P&D ID
PD019262
CAS
111358-88-4
Tags
available
nuisance
obsolete probe
drug candidate
Drug indication
Acute myeloid leukaemia
Psoriasis vulgaris
Myeloid leukaemia
Drug Status
investigational
Max Phase
3.0
SMILES
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O
InChI
InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1
InChIkey
UIARLYUEJFELEN-LROUJFHJSA-N
MOL
LESTAURTINIB
RDKit 2D
33 40 0 0 0 0 0 0 0 0999 V2000
3.4199 -7.0384 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
2.5382 -5.8249 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.2490 -4.5040 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
2.6595 -3.1247 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
4.0638 -3.6517 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
3.9965 -5.1502 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
4.2423 -6.6300 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
5.4938 -5.0605 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
6.3202 -6.3124 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
1.2135 -2.7256 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
0.7500 -1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.5000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
0.7500 1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.7500 1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.5000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.7500 -1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.2135 -2.7256 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.5518 -3.5691 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-2.6191 -5.0676 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.3550 -5.8751 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.0212 -7.3375 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.8846 -8.5641 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-1.2541 -9.9251 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
0.2399 -10.0596 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.1033 -8.8330 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
0.4728 -7.4720 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.0623 -6.0927 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
-0.0673 -5.1058 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.0000 -3.6073 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.0650 -5.4667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.8913 -4.2148 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0
-3.9561 -3.0421 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.3552 -1.5961 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0
2 1 1 6
2 3 1 0
3 4 1 0
4 5 1 1
5 6 1 0
6 7 1 1
6 8 1 0
8 9 1 0
4 10 1 0
10 11 1 0
11 12 2 0
12 13 1 0
13 14 2 0
14 15 1 0
15 16 2 0
16 17 1 0
17 18 2 0
18 19 1 0
19 20 2 0
20 21 1 0
21 22 2 0
22 23 1 0
23 24 2 0
24 25 1 0
25 26 2 0
26 27 1 0
27 28 1 0
28 29 2 0
19 30 1 0
30 31 1 0
31 32 1 0
32 33 2 0
6 2 1 0
29 10 1 0
27 2 1 0
16 11 1 0
29 17 1 0
32 18 1 0
28 20 1 0
26 21 1 0
M END
> <ID>
PD019262
> <Name>
LESTAURTINIB
(extracted from source data)
DESCRIPTION
Lestaurtinib was identified as an inhibitor of the receptor tyrosine kinase (RTK) FLT3 (fms-related tyrosine kinase 3) with activity against leukemia cells in vitro and in vivo . It has activity against other RTKs. A drug repurposing sceen for breast cancer has identified lestaurtinib as a promising agent which appears to sensitise BRCA mutant and wild type breast cancer cells to the effects of the Poly (ADP-ribose) polymerase 1 (PARP1) inhibitor .
(GtoPdb)
357
9.41
PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
BIOCHEM 1.4x
1
2
9.28
MAP3K19 Mitogen-activated protein kinase kinase kinase 19
0
2
9
LATS2 Serine/threonine-protein kinase LATS2 inhibitor
1
2
9
NUAK2 NUAK family SNF1-like kinase 2
0
3
8.85
MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2
0
2
8.82
PLK4 Serine/threonine-protein kinase PLK4
7
3
8.77
8
JAK2 Tyrosine-protein kinase JAK2
38
6
8.77
PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
1
3
8.74
PKN2 Serine/threonine-protein kinase N2
6
3
8.64
JAK3 Tyrosine-protein kinase JAK3
11
2
8.62
STK3 Serine/threonine-protein kinase 3
1
3
8.55
CHEK1 Serine/threonine-protein kinase Chk1
10
3
8.54
MAP3K7 Mitogen-activated protein kinase kinase kinase 7
18
2
8.52
LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2
1
1
8.52
CLK4 Dual specificity protein kinase CLK4
0
2
8.52
STK4 Serine/threonine-protein kinase 4
1
3
8.51
AAK1 AP2-associated protein kinase 1
2
3
8.47
PDPK1 3-phosphoinositide-dependent protein kinase 1
20
2
8.47
STK17A Serine/threonine-protein kinase 17A
0
2
8.47
MAP3K15 Mitogen-activated protein kinase kinase kinase 15
0
2
8.46
MAP3K9 Mitogen-activated protein kinase kinase kinase 9
0
2
8.46
MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1
15
3
8.44
MINK1 Misshapen-like kinase 1
1
3
8.43
NUAK1 NUAK family SNF1-like kinase 1
1
2
8.42
MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4
5
3
8.41
MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2
14
3
8.39
EIF2AK4 eIF-2-alpha kinase GCN2
1
2
8.39
AURKC Aurora kinase C
0
2
8.33
MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2
0
3
8.32
MAP3K2 Mitogen-activated protein kinase kinase kinase 2
0
3
8.31
ULK3 Serine/threonine-protein kinase ULK3
1
3
8.31
MAPK15 Mitogen-activated protein kinase 15
0
2
8.3
STK17B Serine/threonine-protein kinase 17B
0
2
8.3
MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3
3
3
8.28
PKN1 Serine/threonine-protein kinase N1
6
3
8.28
DSTYK Dual serine/threonine and tyrosine protein kinase
0
1
8.27
TNIK Traf2 and NCK-interacting protein kinase
1
2
8.25
CDPK1 Calcium-dependent protein kinase 1
0
1
8.24
SGK3 Serine/threonine-protein kinase Sgk3
1
1
8.24
ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1
1
3
8.24
STK10 Serine/threonine-protein kinase 10
4
3
8.22
MAP3K3 Mitogen-activated protein kinase kinase kinase 3
1
3
8.21
IRAK1 Interleukin-1 receptor-associated kinase 1
18
2
8.19
TTK Dual specificity protein kinase TTK
0
2
8.18
TNKS2 Poly [ADP-ribose] polymerase tankyrase-2
5
1
8.14
GAK Cyclin-G-associated kinase
2
3
8.14
GRK7 Rhodopsin kinase GRK7
1
2
8.11
RIOK3 Serine/threonine-protein kinase RIO3
1
2
8.09
PRKD2 Serine/threonine-protein kinase D2
1
3
8.08
NTRK1 High affinity nerve growth factor receptor
10
3
8.07
8.6
FLT3 Receptor-type tyrosine-protein kinase FLT3 inhibitor
CELL-BASED 4x
27
12
8.06
CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta
20
3
8.06
JAK1 Tyrosine-protein kinase JAK1
29
2
8.05
CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha
31
2
8.05
RIOK1 Serine/threonine-protein kinase RIO1
1
2
8.05
PRKD3 Serine/threonine-protein kinase D3
1
3
8.03
TNK1 Non-receptor tyrosine-protein kinase TNK1
0
3
8.02
SYK Tyrosine-protein kinase SYK
21
3
8.02
CLK1 Dual specificity protein kinase CLK1
0
3
8
PAK6 Serine/threonine-protein kinase PAK 6
6
2
8
SRPK1 SRSF protein kinase 1
2
2
8
CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha
21
2
8
CDKL5 Cyclin-dependent kinase-like 5
0
2
8
STAT5A Signal transducer and activator of transcription 5A
22
1
8
STAT3 Signal transducer and activator of transcription 3
38
1
7.96
IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon
13
3
7.96
MAPK8 Mitogen-activated protein kinase 8
12
3
7.92
IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta
29
2
7.92
GRK4 G protein-coupled receptor kinase 4
1
2
7.92
MAPK10 Mitogen-activated protein kinase 10
4
3
7.91
IRAK4 Interleukin-1 receptor-associated kinase 4
10
2
7.89
SRPK3 SRSF protein kinase 3
0
2
7.89
MYLK Myosin light chain kinase, smooth muscle
2
2
7.89
RIPK4 Receptor-interacting serine/threonine-protein kinase 4
0
2
7.85
MARK2 Serine/threonine-protein kinase MARK2
0
3
7.85
RET Proto-oncogene tyrosine-protein kinase receptor Ret
5
3
7.85
NTRK3 NT-3 growth factor receptor
10
2
7.85
NTRK2 BDNF/NT-3 growth factors receptor
14
2
7.85
PRKD1 Serine/threonine-protein kinase D1
1
2
7.82
SIK2 Serine/threonine-protein kinase SIK2
0
3
7.82
CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2
4
3
7.82
MAP3K10 Mitogen-activated protein kinase kinase kinase 10
0
2
7.8
BMP2K BMP-2-inducible protein kinase
0
3
7.8
BRSK2 Serine/threonine-protein kinase BRSK2
0
2
7.8
AURKB Aurora kinase B
10
3
7.8
IRAK3 Interleukin-1 receptor-associated kinase 3
2
3
7.8
ZAP70 Tyrosine-protein kinase ZAP-70
4
2
7.8
AURKA Aurora kinase A
8
3
7.77
FLT4 Vascular endothelial growth factor receptor 3
3
2
7.75
TBK1 Serine/threonine-protein kinase TBK1
19
3
7.75
MAP3K11 Mitogen-activated protein kinase kinase kinase 11
7
4
7.75
PIP4K2B Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
4
2
7.75
PIM3 Serine/threonine-protein kinase pim-3
0
2
7.72
STK16 Serine/threonine-protein kinase 16
0
2
7.72
MAST1 Microtubule-associated serine/threonine-protein kinase 1
0
2
7.7
CDK2 Cyclin-dependent kinase 2
27
3
7.7
7.92
DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A
1
4
7.68
TNK2 Activated CDC42 kinase 1
1
2
7.66
DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2
1
2
7.64
CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1
3
2
7.64
MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4
1
3
7.62
PAK5 Serine/threonine-protein kinase PAK 5
5
2
7.62
PAK4 Serine/threonine-protein kinase PAK 4
11
3
7.62
GRK1 Rhodopsin kinase GRK1
1
2
7.6
BRSK1 Serine/threonine-protein kinase BRSK1
0
2
7.6
PRKG2 cGMP-dependent protein kinase 2
4
2
7.6
PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1
5
3
7.58
MELK Maternal embryonic leucine zipper kinase
0
3
7.58
ROS1 Proto-oncogene tyrosine-protein kinase ROS
0
2
7.58
STK33 Serine/threonine-protein kinase 33
0
2
7.57
CDK16 Cyclin-dependent kinase 16
0
2
7.55
FER Tyrosine-protein kinase Fer
1
3
7.54
MYLK4 Myosin light chain kinase family member 4
0
2
7.54
DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B
0
2
7.54
PDGFRB Platelet-derived growth factor receptor beta
6
3
7.52
LATS1 Serine/threonine-protein kinase LATS1 inhibitor
1
3
7.52
PAK1 Serine/threonine-protein kinase PAK 1
26
2
7.5
MERTK Tyrosine-protein kinase Mer
1
2
7.5
ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1
0
2
7.47
MYLK3 Myosin light chain kinase 3
0
2
7.46
CDK4 Cyclin-dependent kinase 4
18
2
7.46
AXL Tyrosine-protein kinase receptor UFO
1
2
7.46
PAK3 Serine/threonine-protein kinase PAK 3
13
2
7.46
SLK STE20-like serine/threonine-protein kinase
3
3
7.44
PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
2
2
7.42
MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1
0
3
7.41
CILK1 Serine/threonine-protein kinase ICK
0
2
7.39
PTK2B Protein-tyrosine kinase 2-beta
4
3
7.38
PRKX cAMP-dependent protein kinase catalytic subunit PRKX
4
3
7.37
CDKL2 Cyclin-dependent kinase-like 2
0
2
7.37
PAK2 Serine/threonine-protein kinase PAK 2
27
2
7.37
MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5
0
3
7.36
MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6
8
3
7.36
CLK2 Dual specificity protein kinase CLK2
0
2
7.35
KIT Mast/stem cell growth factor receptor Kit
20
2
7.33
CAMK1D Calcium/calmodulin-dependent protein kinase type 1D
0
2
7.31
MARK3 MAP/microtubule affinity-regulating kinase 3
10
3
7.29
SRPK2 SRSF protein kinase 2
1
2
7.28
FGR Tyrosine-protein kinase Fgr
5
2
7.26
PKNB Serine/threonine-protein kinase PknB
0
1
7.25
MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1
1
2
7.25
ROCK1 Rho-associated protein kinase 1
15
2
7.25
PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2
11
2
7.25
MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle
0
2
7.24
STK11 Serine/threonine-protein kinase STK11
4
2
7.24
BMPR1B Bone morphogenetic protein receptor type-1B
1
2
7.23
CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta
21
2
7.22
ULK2 Serine/threonine-protein kinase ULK2
0
2
7.2
DAPK2 Death-associated protein kinase 2
1
2
7.19
TLK2 Serine/threonine-protein kinase tousled-like 2
0
2
7.18
BTK Tyrosine-protein kinase BTK
14
3
7.16
MAP3K5 Mitogen-activated protein kinase kinase kinase 5
1
3
7.16
TAOK1 Serine/threonine-protein kinase TAO1
6
2
7.15
ROCK2 Rho-associated protein kinase 2
12
2
7.15
ALK ALK tyrosine kinase receptor
11
2
7.12
ACVR1 Activin receptor type-1
0
3
7.1
DAPK1 Death-associated protein kinase 1
1
2
7.1
Uncharacterized protein FLJ45252
0
1
7.1
MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7
4
1
7.09
DAPK3 Death-associated protein kinase 3
1
2
7.09
SIK1 Serine/threonine-protein kinase SIK1
1
2
7.08
MARK1 Serine/threonine-protein kinase MARK1
0
2
7.08
FYN Tyrosine-protein kinase Fyn
44
2
7.07
ACVR1B Activin receptor type-1B
3
3
7.07
TAOK3 Serine/threonine-protein kinase TAO3
3
2
7.07
CIT Citron Rho-interacting kinase
5
2
7.06
CDK7 Cyclin-dependent kinase 7
34
2
7.04
CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma
21
3
7.01
STK25 Serine/threonine-protein kinase 25
0
2
7.01
EPHB6 Ephrin type-B receptor 6
4
2
7.01
TSSK1B Testis-specific serine/threonine-protein kinase 1
0
2
7
PRKCQ Protein kinase C theta type
9
2
6.96
7.51
CSF1R Macrophage colony-stimulating factor 1 receptor
3
3
6.96
MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3
0
3
6.96
TLK1 Serine/threonine-protein kinase tousled-like 1
0
2
6.95
MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5
1
2
6.93
RPS6KB1 Ribosomal protein S6 kinase beta-1
1
2
6.93
TYK2 Non-receptor tyrosine-protein kinase TYK2
20
2
6.92
EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase
6
2
6.92
SBK3 Uncharacterized serine/threonine-protein kinase SBK3
0
2
6.92
MARK4 MAP/microtubule affinity-regulating kinase 4
1
3
6.92
SIK3 Serine/threonine-protein kinase SIK3
0
3
6.92
TGFBR1 TGF-beta receptor type-1
10
3
6.92
FLT1 Vascular endothelial growth factor receptor 1
2
2
6.89
CAMK1 Calcium/calmodulin-dependent protein kinase type 1
2
2
6.85
PRKCH Protein kinase C eta type
2
2
6.85
RPS6KA4 Ribosomal protein S6 kinase alpha-4
1
3
6.82
HIPK4 Homeodomain-interacting protein kinase 4
0
2
6.8
PRKACB cAMP-dependent protein kinase catalytic subunit beta
27
2
6.8
EPHA3 Ephrin type-A receptor 3
3
2
6.8
PRKCE Protein kinase C epsilon type
5
2
6.8
BLK Tyrosine-protein kinase Blk
2
2
6.8
YES1 Tyrosine-protein kinase Yes
17
2
6.77
MAP3K6 Mitogen-activated protein kinase kinase kinase 6
0
3
6.72
LYN Tyrosine-protein kinase Lyn
36
2
6.7
PIM1 Serine/threonine-protein kinase pim-1
3
2
6.7
BMX Cytoplasmic tyrosine-protein kinase BMX
2
2
6.7
SBK1 Serine/threonine-protein kinase SBK1
0
1
6.68
CHEK2 Serine/threonine-protein kinase Chk2
8
2
6.66
PRKACA cAMP-dependent protein kinase catalytic subunit alpha
39
1
6.66
PLK1 Serine/threonine-protein kinase PLK1
25
2
6.66
STK38 Serine/threonine-protein kinase 38
2
2
6.66
KDR Vascular endothelial growth factor receptor 2
7
2
6.64
PIK3C2G Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma
2
2
6.64
MAPKAPK2 MAP kinase-activated protein kinase 2
10
2
6.64
STK26 Serine/threonine-protein kinase 26
1
2
6.62
PRKCD Protein kinase C delta type
14
2
6.62
DMPK Myotonin-protein kinase
1
2
6.6
HIPK3 Homeodomain-interacting protein kinase 3
0
2
6.6
PIM2 Serine/threonine-protein kinase pim-2
0
2
6.59
MET Hepatocyte growth factor receptor
19
2
6.58
MYO3A Myosin-IIIa
2
2
6.58
EPHA7 Ephrin type-A receptor 7
3
2
6.58
CSK Tyrosine-protein kinase CSK
13
2
6.57
HCK Tyrosine-protein kinase HCK
9
2
6.54
RPS6KA2 Ribosomal protein S6 kinase alpha-2
7
2
6.54
TESK1 Dual specificity testis-specific protein kinase 1
1
2
6.54
PI4KB Phosphatidylinositol 4-kinase beta
1
2
6.54
RPS6KA5 Ribosomal protein S6 kinase alpha-5
5
2
6.54
ITK Tyrosine-protein kinase ITK/TSK
2
2
6.54
ERN2 Serine/threonine-protein kinase/endoribonuclease IRE2
0
1
6.54
RPS6KA1 Ribosomal protein S6 kinase alpha-1
8
3
6.51
FGFR1 Fibroblast growth factor receptor 1
22
2
6.5
MAPK9 Mitogen-activated protein kinase 9
5
3
6.48
RPS6KA6 Ribosomal protein S6 kinase alpha-6
3
3
6.48
CASK Peripheral plasma membrane protein CASK
7
1
6.48
PLK2 Serine/threonine-protein kinase PLK2
3
2
6.47
MAP3K13 Mitogen-activated protein kinase kinase kinase 13
0
2
6.46
PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
9
2
6.44
PDGFRA Platelet-derived growth factor receptor alpha
13
2
6.43
STK38L Serine/threonine-protein kinase 38-like
0
2
6.43
FES Tyrosine-protein kinase Fes/Fps
4
3
6.43
HIPK2 Homeodomain-interacting protein kinase 2
6
2
6.43
MAPK12 Mitogen-activated protein kinase 12
6
2
6.43
PRKG1 cGMP-dependent protein kinase 1
3
2
6.42
EPHA1 Ephrin type-A receptor 1
4
2
6.4
DDR2 Discoidin domain-containing receptor 2
1
2
6.39
CDK5 Cyclin-dependent kinase 5
9
3
6.38
CDK3 Cyclin-dependent kinase 3
0
3
6.38
CSNK2A2 Casein kinase II subunit alpha'
11
2
6.37
CDKL3 Cyclin-dependent kinase-like 3
0
2
6.37
LCK Proto-oncogene tyrosine-protein kinase LCK
23
2
6.37
CSNK2A1 Casein kinase II subunit alpha
11
2
6.33
CAMK1G Calcium/calmodulin-dependent protein kinase type 1G
0
1
6.31
LTK Leukocyte tyrosine kinase receptor
1
2
6.31
CDKL1 Cyclin-dependent kinase-like 1
0
1
6.3
TAOK2 Serine/threonine-protein kinase TAO2
0
1
6.29
DDR1 Epithelial discoidin domain-containing receptor 1
1
2
6.28
CDK9 Cyclin-dependent kinase 9
15
2
6.27
TGFBR2 TGF-beta receptor type-2
10
3
6.26
PRP4K Serine/threonine-protein kinase PRP4 homolog
1
2
6.24
HUNK Hormonally up-regulated neu tumor-associated kinase
0
2
6.23
HIPK1 Homeodomain-interacting protein kinase 1
3
2
6.2
PRKCA Protein kinase C alpha type
20
2
6.2
TEK Angiopoietin-1 receptor
2
2
6.19
RIPK2 Receptor-interacting serine/threonine-protein kinase 2
9
2
6.19
TYRO3 Tyrosine-protein kinase receptor TYRO3
0
2
6.19
FGFR3 Fibroblast growth factor receptor 3
16
2
6.19
SRC Proto-oncogene tyrosine-protein kinase Src
68
2
6.18
FGFR2 Fibroblast growth factor receptor 2
17
2
6.18
TXK Tyrosine-protein kinase TXK
1
2
6.17
TIE1 Tyrosine-protein kinase receptor Tie-1
0
2
6.14
CDK17 Cyclin-dependent kinase 17
0
2
6.14
CDK14 Cyclin-dependent kinase 14
0
2
6.13
FRK Tyrosine-protein kinase FRK
2
2
6.12
STK24 Serine/threonine-protein kinase 24
2
2
6.11
MYO3B Myosin-IIIb
2
2
6.11
NLK Serine/threonine-protein kinase NLK
1
2
6.1
EGFR Epidermal growth factor receptor
36
2
6.1
EPHA2 Ephrin type-A receptor 2
12
2
6.09
STK35 Serine/threonine-protein kinase 35
0
2
6.09
SRMS Tyrosine-protein kinase Srms
1
2
6.08
DLK1 Protein delta homolog 1
1
2
6.08
MAP3K12 Mitogen-activated protein kinase kinase kinase 12
0
1
6.05
PRKAG1 5'-AMP-activated protein kinase subunit gamma-1
8
1
6.05
PRKAG2 5'-AMP-activated protein kinase subunit gamma-2
10
1
6.03
MAPKAPK5 MAP kinase-activated protein kinase 5
3
2
6.02
BMPR1A Bone morphogenetic protein receptor type-1A
1
2
6.01
ABL1 Tyrosine-protein kinase ABL1
13
2
6.01
MATK Megakaryocyte-associated tyrosine-protein kinase
1
2
6
ULK1 Serine/threonine-protein kinase ULK1
5
2
6
CDC42BPB Serine/threonine-protein kinase MRCK beta
3
2
6
CDK13 Cyclin-dependent kinase 13
2
1
5.96
STK39 STE20/SPS1-related proline-alanine-rich protein kinase
0
2
5.96
MAPK7 Mitogen-activated protein kinase 7
6
2
5.96
DCLK3 Serine/threonine-protein kinase DCLK3
0
2
5.96
PTK2 Focal adhesion kinase 1
17
2
5.96
INSR Insulin receptor
6
2
5.92
EPHA6 Ephrin type-A receptor 6
3
2
5.92
TEC Tyrosine-protein kinase Tec
3
2
5.92
WEE1 Wee1-like protein kinase
7
2
5.89
RPS6KA3 Ribosomal protein S6 kinase alpha-3
7
3
5.89
GSK3B Glycogen synthase kinase-3 beta
24
1
5.89
CDK15 Cyclin-dependent kinase 15
0
2
5.86
PKN3 Serine/threonine-protein kinase N3
4
1
5.85
ERBB4 Receptor tyrosine-protein kinase erbB-4
20
2
5.82
BMPR2 Bone morphogenetic protein receptor type-2
1
3
5.8
LIMK1 LIM domain kinase 1
6
2
5.8
HTT Huntingtin
1
1
5.77
MAK Serine/threonine-protein kinase MAK
0
2
5.77
PTK6 Protein-tyrosine kinase 6
12
3
5.77
EPHA4 Ephrin type-A receptor 4
4
2
5.75
PRKCI Protein kinase C iota type
4
1
5.75
FGFR4 Fibroblast growth factor receptor 4
14
2
5.75
INSRR Insulin receptor-related protein
0
2
5.75
NIM1K Serine/threonine-protein kinase NIM1
0
2
5.75
CDK6 Cyclin-dependent kinase 6
9
1
5.68
TNNI3K Serine/threonine-protein kinase TNNI3K
0
2
5.68
AKT2 RAC-beta serine/threonine-protein kinase
32
2
5.68
STK32A Serine/threonine-protein kinase 32A
0
1
5.66
ACVRL1 Activin receptor type-1-like
1
2
5.64
PLK3 Serine/threonine-protein kinase PLK3
2
2
5.64
GSK3A Glycogen synthase kinase-3 alpha
6
2
5.6
ACVR2A Activin receptor type-2A
5
2
5.6
NEK1 Serine/threonine-protein kinase Nek1
1
2
5.6
CDC42BPG Serine/threonine-protein kinase MRCK gamma
0
2
5.58
MAP3K4 Mitogen-activated protein kinase kinase kinase 4
0
2
5.52
CAMK4 Calcium/calmodulin-dependent protein kinase type IV
6
2
5.49
NQO2 Ribosyldihydronicotinamide dehydrogenase [quinone]
1
1
5.46
MAPK13 Mitogen-activated protein kinase 13
3
2
5.42
STK36 Serine/threonine-protein kinase 36
0
2
5.42
ACVR2B Activin receptor type-2B
4
2
5.4
PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
14
1
5.4
NEK7 Serine/threonine-protein kinase Nek7
3
2
5.39
MUSK Muscle, skeletal receptor tyrosine-protein kinase
1
1
5.38
IGF1R Insulin-like growth factor 1 receptor
5
2
5.36
MAP3K1 Mitogen-activated protein kinase kinase kinase 1
5
2
5.36
AKT1 RAC-alpha serine/threonine-protein kinase
42
2
5.36
NEK6 Serine/threonine-protein kinase Nek6
3
1
5.35
DCLK2 Serine/threonine-protein kinase DCLK2
0
1
5.31
PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
60
2
5.31
NEK2 Serine/threonine-protein kinase Nek2
8
1
5.28
PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
1
1
5.28
EPHB1 Ephrin type-B receptor 1
4
2
5.27
NEK9 Serine/threonine-protein kinase Nek9
3
1
5.26
ERBB3 Receptor tyrosine-protein kinase erbB-3
15
1
5.25
NEK5 Serine/threonine-protein kinase Nek5
0
1
5.25
CRK2 Cyclin-dependent kinase 2 homolog
0
1
5.23
STK32B Serine/threonine-protein kinase 32B
0
2
5.23
EPHA5 Ephrin type-A receptor 5
3
1
5.21
AKT3 RAC-gamma serine/threonine-protein kinase
27
2
5.19
ABL2 Tyrosine-protein kinase ABL2
4
1
5.17
MAP3K20 Mitogen-activated protein kinase kinase kinase 20
0
1
5.17
RIOK2 Serine/threonine-protein kinase RIO2
1
2
5.17
PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
32
1
5.16
EPHB4 Ephrin type-B receptor 4
4
1
5.16
EPHB2 Ephrin type-B receptor 2
5
1
5.15
CSNK1A1L Casein kinase I isoform alpha-like
0
1
5.1
CDK8 Cyclin-dependent kinase 8
9
1
5.1
OXSR1 Serine/threonine-protein kinase OSR1
0
1
5.1
WEE2 Wee1-like protein kinase 2
0
1
5.1
STK32C Serine/threonine-protein kinase 32C
0
1
5.09
MST1R Macrophage-stimulating protein receptor
1
2
5.04
CDC42BPA Serine/threonine-protein kinase MRCK alpha
4
1
5.01
MAPK3 Mitogen-activated protein kinase 3
59
1
4.95
RORC Nuclear receptor ROR-gamma
3
1
4.8
KMT2A,MEN1 Menin/Histone-lysine N-methyltransferase MLL
0
1
779
Acetylcholine regulates insulin secretion
PRKCA
Activated NOTCH1 Transmits Signal to the Nucleus
DLK1
Activated NTRK2 signals through CDK5
CDK5
NTRK2
Activated NTRK2 signals through FRS2 and FRS3
NTRK2
Activated NTRK2 signals through FYN
FYN
SRC
NTRK2
Activated NTRK2 signals through PI3K
PIK3CA
NTRK2
Activated NTRK2 signals through PLCG1
NTRK2
Activated NTRK2 signals through RAS
NTRK2
Activated NTRK3 signals through PI3K
PIK3CA
NTRK3
SRC
Activated NTRK3 signals through PLCG1
NTRK3
Activated NTRK3 signals through RAS
NTRK3
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
PKN1
Activated point mutants of FGFR2
FGFR2
activated TAK1 mediates p38 MAPK activation
IRAK1
MAPKAPK2
MAP3K7
MAP2K6
RIPK2
MAP2K3
Activation of AKT2
AKT2
PDPK1
Activation of AMPK downstream of NMDARs
PRKAG2
PRKAA1
PRKAA2
CAMKK2
PRKAG1
Activation of ATR in response to replication stress
CHEK1
CDK2
Activation of BAD and translocation to mitochondria
AKT1
AKT2
AKT3
Activation of BIM and translocation to mitochondria
MAPK8
Activation of BMF and translocation to mitochondria
MAPK8
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
IKBKE
TBK1
Activation of NF-kappaB in B cells
MAP3K7
CHUK
IKBKB
Activation of NIMA Kinases NEK9, NEK6, NEK7
NEK6
PLK1
NEK9
NEK7
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
MAPK12
PRKAG2
PRKAA2
PRKAG1
Activation of RAC1
PAK5
PAK6
PAK2
PAK3
PAK4
PAK1
Activation of RAC1 downstream of NMDARs
CAMK1
CAMKK2
CAMKK1
Activation of the AP-1 family of transcription factors
MAPK3
MAPK9
MAPK8
MAPK10
Activation of the pre-replicative complex
CDK2
ADORA2B mediated anti-inflammatory cytokines production
PRKX
PRKACB
PRKACA
ADP signalling through P2Y purinoceptor 1
SRC
Advanced glycosylation endproduct receptor signaling
MAPK3
AKT phosphorylates targets in the cytosol
AKT1
AKT2
AKT3
CHUK
GSK3B
GSK3A
AKT phosphorylates targets in the nucleus
AKT1
AKT2
AKT3
AKT-mediated inactivation of FOXO1A
AKT1
AKT2
AKT3
alectinib-resistant ALK mutants
ALK
ALK mutants bind TKIs
ALK
Alpha-protein kinase 1 signaling pathway
MAP3K7
AMPK inhibits chREBP transcriptional activation activity
PRKAG2
STK11
PRKAA2
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PLK1
TAOK1
AURKB
Anchoring of the basal body to the plasma membrane
PLK1
NEK2
MARK4
PLK4
PRKACA
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
LYN
PIK3CD
FYN
BLK
BTK
SYK
APC truncation mutants have impaired AXIN binding
GSK3B
APC-Cdc20 mediated degradation of Nek2A
NEK2
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
PLK1
AURKA
AURKB
Apoptotic cleavage of cellular proteins
PTK2
BMX
PRKCQ
STK24
PRKCD
ROCK1
STK26
Apoptotic execution phase
STK24
ARMS-mediated activation
NTRK1
ASP-3026-resistant ALK mutants
ALK
Assembly and cell surface presentation of NMDA receptors
CAMK2B
CAMK2D
CAMK2G
CAMK2A
CASK
Association of TriC/CCT with target proteins during biosynthesis
STAT3
AURKA Activation by TPX2
PLK1
NEK2
AURKA
PLK4
PRKACA
AXIN missense mutants destabilize the destruction complex
GSK3B
B-WICH complex positively regulates rRNA expression
GSK3B
BDNF activates NTRK2 (TRKB) signaling
NTRK2
Beta-catenin phosphorylation cascade
GSK3B
betaKlotho-mediated ligand binding
FGFR4
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
STAT3
brigatinib-resistant ALK mutants
ALK
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
MAPKAPK2
AKT1
Ca2+ pathway
MAP3K7
PRKG2
PRKG1
NLK
PRKCA
CAMK2A
Calmodulin induced events
PRKCD
PRKCA
CaMK IV-mediated phosphorylation of CREB
CAMK4
CAMK2B
CAMKK2
CAMK2D
CAMKK1
CAMK2G
CAMK2A
Cargo recognition for clathrin-mediated endocytosis
EGFR
AAK1
Carnitine shuttle
PRKAG2
PRKAA2
Caspase activation via Dependence Receptors in the absence of ligand
DAPK3
DAPK2
DAPK1
CD163 mediating an anti-inflammatory response
PLK2
CD209 (DC-SIGN) signaling
LYN
RPS6KA5
PRKACB
FYN
PAK2
PAK3
PAK1
PRKACA
CD22 mediated BCR regulation
LYN
CD28 dependent PI3K/Akt signaling
PIK3CB
PIK3CD
PIK3CA
AKT1
AKT2
AKT3
FYN
PIK3CG
LCK
PDPK1
CD28 dependent Vav1 pathway
FYN
PAK2
PAK3
LCK
PAK1
CDC42 GTPase cycle
PAK5
CDC42BPA
PAK6
CDC42BPB
PAK2
MAP3K11
PAK3
PAK4
PAK1
CDK-mediated phosphorylation and removal of Cdc6
CDK2
Cell surface interactions at the vascular wall
LYN
MERTK
FYN
ceritinib-resistant ALK mutants
ALK
cGMP effects
PRKG2
PRKG1
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
CHEK2
CHEK1
WEE1
Circadian Clock
SIK1
Clathrin-mediated endocytosis
GAK
EGFR
AAK1
CLEC7A (Dectin-1) signaling
PRKCD
MAP3K7
CHUK
SYK
PDPK1
SRC
IKBKB
Co-inhibition by CTLA4
LYN
AKT1
AKT2
YES1
AKT3
FYN
LCK
SRC
Co-inhibition by PD-1
CSK
LCK
Co-stimulation by CD28
LYN
YES1
FYN
LCK
SRC
Co-stimulation by ICOS
PIK3CB
PIK3CD
PIK3CA
PIK3CG
Condensation of Prometaphase Chromosomes
CSNK2A1
CSNK2A2
Condensation of Prophase Chromosomes
PLK1
Constitutive Signaling by Aberrant PI3K in Cancer
PIK3CB
FGFR1
PIK3CD
PIK3CA
PDGFRB
ERBB4
FGFR2
FLT3
PDGFRA
FGFR4
NTRK3
FYN
FGFR3
EGFR
MET
PIK3CG
ERBB3
LCK
SRC
NTRK2
KIT
Constitutive Signaling by AKT1 E17K in Cancer
AKT1
AKT2
AKT3
CHUK
PDPK1
GSK3B
GSK3A
Constitutive Signaling by EGFRvIII
PIK3CA
EGFR
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PIK3CA
EGFR
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
CDK8
Constitutive Signaling by NOTCH1 PEST Domain Mutants
CDK8
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
CSNK2A1
CSNK2A2
CREB phosphorylation
RPS6KA3
RPS6KA5
MAPKAPK2
RPS6KA2
RPS6KA1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
RPS6KA3
RPS6KA2
RPS6KA1
RPS6KA6
CREB1 phosphorylation through the activation of Adenylate Cyclase
PRKX
PRKACB
PRKACA
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
CAMK4
CAMK2B
CAMKK2
CAMKK1
CAMK2G
crenolanib-resistant FLT3 mutants
FLT3
crizotinib-resistant ALK mutants
ALK
CRMPs in Sema3A signaling
CDK5
FES
FYN
GSK3B
CTNNB1 S33 mutants aren't phosphorylated
GSK3B
CTNNB1 S37 mutants aren't phosphorylated
GSK3B
CTNNB1 S45 mutants aren't phosphorylated
GSK3B
CTNNB1 T41 mutants aren't phosphorylated
GSK3B
Cyclin A/B1/B2 associated events during G2/M transition
PLK1
CDK2
WEE1
CDK7
Cyclin A:Cdk2-associated events at S phase entry
AKT1
AKT2
AKT3
CDK2
WEE1
CDK7
Cyclin D associated events in G1
PTK6
LYN
JAK2
ABL1
CDK2
SRC
CDK6
CDK7
CDK4
Cyclin E associated events during G1/S transition
AKT1
AKT2
AKT3
CDK2
WEE1
CDK7
Cytoprotection by HMOX1
PTK6
STAT3
DAG and IP3 signaling
PRKCD
PRKCE
DAP12 signaling
PIK3CB
PIK3CA
FYN
BTK
SYK
LCK
DARPP-32 events
CDK5
PRKACB
PRKACA
Dasatinib-resistant KIT mutants
KIT
DCC mediated attractive signaling
PTK2
FYN
SRC
DDX58/IFIH1-mediated induction of interferon-alpha/beta
TBK1
Deactivation of the beta-catenin transactivating complex
AKT1
AKT2
Dectin-1 mediated noncanonical NF-kB signaling
CHUK
Dectin-2 family
LYN
FYN
SYK
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
CDK2
CDK6
CDK4
Degradation of AXIN
TNKS2
Degradation of beta-catenin by the destruction complex
GSK3B
Degradation of GLI1 by the proteasome
PRKACB
PRKACA
Degradation of GLI2 by the proteasome
PRKACB
GSK3B
PRKACA
Depolymerization of the Nuclear Lamina
PRKCA
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
CDK5
Disassembly of the destruction complex and recruitment of AXIN to the membrane
GSK3B
Disinhibition of SNARE formation
PRKCA
DNA Damage/Telomere Stress Induced Senescence
CDK2
Dopamine Neurotransmitter Release Cycle
CASK
Downregulation of ERBB2 signaling
EGFR
ERBB3
ERBB4
MATK
Downregulation of ERBB2:ERBB3 signaling
AKT1
AKT2
AKT3
ERBB3
Downregulation of ERBB4 signaling
ERBB4
SRC
Downregulation of SMAD2/3:SMAD4 transcriptional activity
MAPK3
Downregulation of TGF-beta receptor signaling
TGFBR2
TGFBR1
Downstream signal transduction
PIK3CB
PIK3CA
PDGFRB
STAT3
PDGFRA
STAT5A
SRC
Downstream signaling of activated FGFR1
FGFR1
Downstream TCR signaling
PIK3CB
PRKCQ
MAP3K7
PIK3CA
RIPK2
CHUK
LCK
PDPK1
IKBKB
Drug-mediated inhibition of CDK4/CDK6 activity
CDK6
CDK4
Drug-mediated inhibition of MET activation
MET
Dual incision in TC-NER
CDK7
ECM proteoglycans
MUSK
Effects of PIP2 hydrolysis
PRKCQ
PRKCD
PRKCE
PRKCH
EGFR downregulation
EGFR
EGFR interacts with phospholipase C-gamma
EGFR
EGFR Transactivation by Gastrin
EGFR
PRKCA
EML4 and NUDC in mitotic spindle formation
NEK6
PLK1
NEK9
NEK7
TAOK1
AURKB
Energy dependent regulation of mTOR by LKB1-AMPK
PRKAG2
STK11
PRKAA1
PRKAA2
PRKAG1
eNOS activation
AKT1
EPH-ephrin mediated repulsion of cells
LYN
YES1
EPHA7
EPHB1
EPHA6
EPHB6
EPHA4
EPHA5
FYN
EPHA1
EPHB4
EPHA3
SRC
EPHB2
EPHA2
EPH-Ephrin signaling
LYN
YES1
EPHA7
EPHB1
EPHA6
EPHB6
EPHA4
EPHA5
FYN
EPHA1
EPHB4
EPHA3
SRC
EPHB2
EPHA2
EPHA-mediated growth cone collapse
ROCK2
LYN
YES1
ROCK1
EPHA7
EPHA6
EPHA4
EPHA5
FYN
EPHA1
EPHA3
SRC
EPHA2
EPHB-mediated forward signaling
PTK2
LIMK1
ROCK2
LYN
YES1
ROCK1
EPHB1
EPHB6
FYN
EPHB4
SRC
EPHB2
PAK1
Ephrin signaling
EPHB1
EPHB6
FYN
PAK2
EPHB4
PAK3
SRC
EPHB2
PAK1
Epithelial-Mesenchymal Transition (EMT) during gastrulation
FGFR1
ER-Phagosome pathway
BTK
CHUK
IKBKB
ERBB2 Activates PTK6 Signaling
PTK6
EGFR
ERBB3
ERBB4
ERBB2 Regulates Cell Motility
ERBB4
EGFR
ERBB3
ERK/MAPK targets
MAPK3
RPS6KA3
RPS6KA5
RPS6KA2
RPS6KA1
MAPK7
ERKs are inactivated
MAPK3
MAPK7
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
LYN
PIK3CB
PIK3CD
PIK3CA
JAK2
PIK3CG
Erythropoietin activates Phospholipase C gamma (PLCG)
LYN
JAK2
Erythropoietin activates RAS
LYN
JAK2
Erythropoietin activates STAT5
LYN
JAK2
STAT5A
ESR-mediated signaling
MAPK3
Estrogen-dependent gene expression
ERBB4
CDK9
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
PTK2
MAPK3
AKT1
AKT2
EGFR
AKT3
Estrogen-stimulated signaling through PRKCZ
PDPK1
Evasion by RSV of host interferon responses
TYK2
JAK1
EIF2AK2
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
CDK6
CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
CDK6
CDK4
Extra-nuclear estrogen signaling
PTK2
PIK3CA
AKT1
EGFR
IGF1R
SRC
Factors involved in megakaryocyte development and platelet production
CDK5
JAK2
ABL1
PRKACB
CDK2
WEE1
PRKACA
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
AURKA
Fc epsilon receptor (FCERI) signaling
LYN
SYK
FCERI mediated Ca+2 mobilization
LYN
ITK
TEC
BTK
SYK
TXK
FCERI mediated MAPK activation
MAP2K4
MAPK3
LYN
MAP2K7
MAPK9
MAPK8
MAP3K1
PAK2
MAPK10
SYK
PAK1
FCERI mediated NF-kB activation
LYN
PRKCQ
MAP3K7
CHUK
PDPK1
IKBKB
FCGR activation
LYN
YES1
FGR
FYN
HCK
SYK
SRC
FCGR3A-mediated IL10 synthesis
LYN
PRKX
YES1
FGR
PRKACB
FYN
HCK
SYK
SRC
PRKACA
FCGR3A-mediated phagocytosis
PTK2
MAPK3
LYN
YES1
FGR
ABL1
FYN
HCK
BTK
SYK
SRC
FGFR1b ligand binding and activation
FGFR1
FGFR1c and Klotho ligand binding and activation
FGFR1
FGFR1c ligand binding and activation
FGFR1
FGFR2b ligand binding and activation
FGFR2
FGFR2c ligand binding and activation
FGFR2
FGFR3b ligand binding and activation
FGFR3
FGFR3c ligand binding and activation
FGFR3
FGFR4 ligand binding and activation
FGFR4
FGFR4 mutant receptor activation
FGFR4
FLT3 mutants bind TKIs
FLT3
FLT3 Signaling
PIK3CA
AKT1
AKT2
FLT3
AKT3
FLT3 signaling by CBL mutants
FLT3
FLT3 signaling through SRC family kinases
FLT3
FYN
HCK
SYK
LCK
Formation of HIV elongation complex in the absence of HIV Tat
CDK9
CDK7
Formation of HIV-1 elongation complex containing HIV-1 Tat
CDK9
CDK7
Formation of Incision Complex in GG-NER
CDK7
Formation of paraxial mesoderm
FGFR1
Formation of RNA Pol II elongation complex
CDK9
CDK7
Formation of TC-NER Pre-Incision Complex
CDK7
Formation of the Early Elongation Complex
CDK7
Formation of the HIV-1 Early Elongation Complex
CDK7
Formation of the nephric duct
RET
Formation of the ureteric bud
RET
FOXO-mediated transcription of cell death genes
STK11
FRS-mediated FGFR1 signaling
FGFR1
FRS-mediated FGFR2 signaling
FGFR2
FRS-mediated FGFR3 signaling
FGFR3
FRS-mediated FGFR4 signaling
FGFR4
Frs2-mediated activation
MAPK3
MAP2K1
NTRK1
MAP2K2
G alpha (12/13) signalling events
ROCK2
ROCK1
BTK
G alpha (i) signalling events
SRC
G alpha (q) signalling events
PIK3CA
BTK
G alpha (s) signalling events
SRC
G alpha (z) signalling events
PRKCQ
PRKCD
PRKCE
PRKCH
PRKCA
G beta:gamma signalling through BTK
BTK
G beta:gamma signalling through CDC42
PAK1
G beta:gamma signalling through PI3Kgamma
AKT1
AKT2
AKT3
PIK3CG
PDPK1
G0 and Early G1
CDK2
DYRK1A
G2 Phase
CDK2
G2/M DNA damage checkpoint
CHEK2
CHEK1
G2/M DNA replication checkpoint
WEE1
GAB1 signalosome
PIK3CA
CSK
EGFR
SRC
Gap-filling DNA repair synthesis and ligation in TC-NER
CDK7
Gastrin-CREB signalling pathway via PKC and MAPK
MAPK3
RPS6KA3
RPS6KA2
RPS6KA1
MAPK7
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
PAK2
Generation of second messenger molecules
ITK
PAK2
ZAP70
PAK3
LCK
PAK1
Generic Transcription Pathway
CDK8
gilteritinib-resistant FLT3 mutants
FLT3
GLI3 is processed to GLI3R by the proteasome
PRKACB
GSK3B
PRKACA
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
PRKACB
PRKACA
Glycogen breakdown (glycogenolysis)
PHKG2
PHKG1
Golgi Associated Vesicle Biogenesis
GAK
Golgi Cisternae Pericentriolar Stack Reorganization
MAPK3
PLK1
GP1b-IX-V activation signalling
SRC
GPER1 signaling
PRKACB
SRC
PRKACA
GPVI-mediated activation cascade
LYN
PIK3CB
PIK3CA
FYN
PIK3CG
SYK
LCK
PDPK1
GRB2 events in EGFR signaling
EGFR
GRB2 events in ERBB2 signaling
ERBB4
EGFR
GRB2:SOS provides linkage to MAPK signaling for Integrins
PTK2
SRC
GRB7 events in ERBB2 signaling
ERBB3
Growth hormone receptor signaling
MAPK3
LYN
STAT3
JAK2
STAT5A
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
GSK3B
HCMV Early Events
EGFR
HDL assembly
PRKACB
PRKACA
HDR through Single Strand Annealing (SSA)
ABL1
Hedgehog 'off' state
PRKACB
PRKACA
Hedgehog 'on' state
ULK3
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
PIK3CB
PIK3CD
PIK3CA
AKT1
PRKACB
FYN
PKN2
PDPK1
FLT4
KDR
PRKACA
HIV elongation arrest and recovery
CDK9
HIV Transcription Initiation
CDK7
HSF1-dependent transactivation
CAMK2B
CAMK2D
CAMK2G
CAMK2A
HuR (ELAVL1) binds and stabilizes mRNA
PRKCD
PRKCA
IFNG signaling activates MAPKs
MAPK3
JAK2
JAK1
IkBA variant leads to EDA-ID
CHUK
IKBKB
IKBKB deficiency causes SCID
CHUK
IKBKB
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
CHUK
IKBKB
IKK complex recruitment mediated by RIP1
CHUK
IKBKB
IL-6-type cytokine receptor ligand interactions
JAK2
TYK2
JAK1
Imatinib-resistant KIT mutants
KIT
Imatinib-resistant PDGFR mutants
PDGFRA
Inactivation of CSF3 (G-CSF) signaling
LYN
STAT3
JAK2
TYK2
STAT5A
JAK1
HCK
SYK
Inactivation, recovery and regulation of the phototransduction cascade
PRKCQ
GRK7
GRK4
PRKCA
GRK1
Inhibition of PKR
EIF2AK2
Inhibition of Signaling by Overexpressed EGFR
EGFR
Inhibition of TSC complex formation by PKB
AKT2
InlA-mediated entry of Listeria monocytogenes into host cells
SRC
InlB-mediated entry of Listeria monocytogenes into host cell
MET
Insulin receptor recycling
INSR
Insulin receptor signalling cascade
INSR
Integrin cell surface interactions
KDR
Integrin signaling
PTK2
AKT1
CSK
SYK
PDPK1
SRC
Interaction between PHLDA1 and AURKA
AURKA
Interactions of Tat with host cellular proteins
CDK9
Interferon alpha/beta signaling
TYK2
JAK1
EIF2AK2
Interferon gamma signaling
MAPK3
PRKCD
JAK2
JAK1
CAMK2B
CAMK2D
CAMK2G
CAMK2A
Interleukin receptor SHC signaling
PIK3CB
PIK3CD
PIK3CA
JAK2
JAK3
JAK1
Interleukin-1 signaling
MAP3K3
IRAK1
MAP3K7
MAP2K6
IRAK3
IRAK4
CHUK
RIPK2
IKBKB
Interleukin-10 signaling
STAT3
TYK2
JAK1
Interleukin-12 signaling
JAK2
TYK2
JAK1
Interleukin-15 signaling
STAT3
JAK3
STAT5A
JAK1
Interleukin-2 signaling
JAK3
STAT5A
PTK2B
JAK1
SYK
LCK
Interleukin-20 family signaling
STAT3
JAK2
JAK3
TYK2
STAT5A
JAK1
Interleukin-21 signaling
STAT3
JAK3
STAT5A
JAK1
Interleukin-23 signaling
STAT3
JAK2
TYK2
Interleukin-27 signaling
STAT3
JAK2
TYK2
JAK1
Interleukin-3, Interleukin-5 and GM-CSF signaling
PIK3CB
PIK3CD
PIK3CA
JAK2
TEC
STAT5A
PRKACA
Interleukin-35 Signalling
STAT3
JAK2
TYK2
JAK1
Interleukin-37 signaling
STAT3
TBK1
Interleukin-38 signaling
MAPK8
Interleukin-4 and Interleukin-13 signaling
AKT1
STAT3
RORC
JAK2
JAK3
TYK2
JAK1
PIM1
Interleukin-6 signaling
STAT3
JAK2
TYK2
JAK1
Interleukin-7 signaling
STAT3
JAK3
STAT5A
JAK1
Interleukin-9 signaling
STAT3
JAK3
STAT5A
JAK1
Ion homeostasis
DMPK
CAMK2B
CAMK2D
CAMK2G
CAMK2A
PRKACA
Ion transport by P-type ATPases
CAMK2B
CAMK2D
CAMK2G
CAMK2A
IRAK1 recruits IKK complex
IRAK1
CHUK
IKBKB
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK1
CHUK
IKBKB
IRAK2 mediated activation of TAK1 complex
MAP3K7
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
MAP3K7
IRAK4 deficiency (TLR2/4)
IRAK4
BTK
IRAK4 deficiency (TLR5)
IRAK4
IRE1alpha activates chaperones
ERN1
IRF3 mediated activation of type 1 IFN
TBK1
IRF3-mediated induction of type I IFN
TBK1
IRS activation
INSR
IRS-mediated signalling
PIK3CB
PIK3CA
IRS-related events triggered by IGF1R
IGF1R
ISG15 antiviral mechanism
MAPK3
JAK1
EIF2AK2
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
MAP2K4
IRAK1
MAP2K7
MAP3K7
MAPK9
MAPK8
RIPK2
MAPK10
KEAP1-NFE2L2 pathway
PRKCD
PRKCI
AKT1
AKT2
CSNK2A1
AKT3
CSNK2A2
KIT mutants bind TKIs
KIT
KSRP (KHSRP) binds and destabilizes mRNA
AKT1
KW2449-resistant FLT3 mutants
FLT3
L1CAM interactions
EPHB2
lestaurtinib-resistant FLT3 mutants
FLT3
linifanib-resistant FLT3 mutants
FLT3
Lipophagy
PRKAG2
PRKAA2
PRKAG1
Long-term potentiation
ERBB4
CAMK2B
CAMK2D
CAMK2G
SRC
CAMK2A
lorlatinib-resistant ALK mutants
ALK
Loss of Nlp from mitotic centrosomes
PLK1
NEK2
PLK4
PRKACA
Loss of phosphorylation of MECP2 at T308
CAMK4
PRKACA
Loss of proteins required for interphase microtubule organization from the centrosome
PLK1
NEK2
PLK4
PRKACA
Macroautophagy
PRKAG2
PRKAA1
PRKAA2
ULK1
PRKAG1
Major pathway of rRNA processing in the nucleolus and cytosol
RIOK1
RIOK2
RIOK3
MAP2K and MAPK activation
MAPK3
MARK3
MAP2K1
CSK
MAP2K2
SRC
MAP3K8 (TPL2)-dependent MAPK1/3 activation
MAP2K4
MAP2K1
CHUK
IKBKB
MAPK1 (ERK2) activation
JAK2
TYK2
JAK1
MAP2K2
MAPK3 (ERK1) activation
MAPK3
MAP2K1
JAK2
TYK2
JAK1
MAPK6/MAPK4 signaling
MAPKAPK5
PRKACB
PAK2
PAK3
PAK1
PRKACA
Masitinib-resistant KIT mutants
KIT
Maturation of hRSV A proteins
CSNK2A1
CSNK2A2
Maturation of nucleoprotein
SRPK2
GSK3B
GSK3A
SRPK1
Maturation of nucleoprotein
GSK3B
GSK3A
MDK and PTN in ALK signaling
ALK
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
AKT1
MECP2 regulates neuronal receptors and channels
MET
Meiotic recombination
CDK2
CDK4
MET activates PI3K/AKT signaling
PIK3CA
MET
MET activates PTK2 signaling
PTK2
MET
SRC
MET activates PTPN11
MET
MET activates RAP1 and RAC1
MET
MET activates RAS signaling
MET
MET activates STAT3
STAT3
MET
MET interacts with TNS proteins
MET
MET Receptor Activation
MET
MET receptor recycling
MET
midostaurin-resistant FLT3 mutants
FLT3
Mitochondrial protein degradation
PRKACA
Mitochondrial unfolded protein response (UPRmt)
AKT1
Mitotic Metaphase/Anaphase Transition
PLK1
Mitotic Prometaphase
PLK1
TAOK1
AURKB
Mitotic Telophase/Cytokinesis
PLK1
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
CDK5
ABL1
CDK8
Modulation of host responses by IFN-stimulated genes
CHUK
IKBKB
mRNA Capping
CDK7
mRNA Splicing - Major Pathway
PRP4K
MTOR signalling
AKT1
mTORC1-mediated signalling
RPS6KB1
MyD88 cascade initiated on plasma membrane
IRAK1
IRAK4
MAP3K1
MyD88 deficiency (TLR2/4)
BTK
MyD88 dependent cascade initiated on endosome
IRAK1
IRAK4
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
IRAK1
IRAK3
IRAK4
MAP3K1
BTK
Myogenesis
MAPK12
MAP2K6
ABL1
NCAM signaling for neurite out-growth
PTK2
MAPK3
RPS6KA5
FGFR1
FYN
SRC
Nef and signal transduction
FYN
PAK2
HCK
LCK
Nef Mediated CD4 Down-regulation
LCK
Negative feedback regulation of MAPK pathway
MAPK3
MAP2K1
MAP2K2
Negative regulation of FGFR1 signaling
MAPK3
FGFR1
Negative regulation of FGFR2 signaling
MAPK3
FGFR2
Negative regulation of FGFR3 signaling
MAPK3
FGFR3
Negative regulation of FGFR4 signaling
MAPK3
FGFR4
Negative regulation of FLT3
ABL2
FLT3
CSK
Negative regulation of MAPK pathway
MAPK12
MAPK3
MARK3
Negative regulation of MET activity
MET
Negative regulation of NMDA receptor-mediated neuronal transmission
CAMK1
CAMK4
CAMK2B
CAMK2D
CAMK2G
CAMK2A
Negative regulation of NOTCH4 signaling
AKT1
Negative regulation of the PI3K/AKT network
AKT1
AKT2
AKT3
Negative regulators of DDX58/IFIH1 signaling
IKBKE
TBK1
Nephrin family interactions
PIK3CB
PIK3CA
FYN
CASK
Netrin mediated repulsion signals
SRC
Netrin-1 signaling
PRKCQ
Neurexins and neuroligins
CASK
Neurophilin interactions with VEGF and VEGFR
FLT1
KDR
Neutrophil degranulation
STK10
PRKCD
ROCK1
FGR
FRK
CDK13
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
CHUK
IKBKB
NF-kB is activated and signals survival
IRAK1
IKBKB
NGF-independant TRKA activation
NTRK1
NTRK2
NGF-stimulated transcription
CDK5
NIK-->noncanonical NF-kB signaling
CHUK
Nilotinib-resistant KIT mutants
KIT
NOD1/2 Signaling Pathway
IRAK1
MAPK12
MAP3K7
MAP2K6
RIPK2
CHUK
IKBKB
MAPK13
Non-integrin membrane-ECM interactions
DDR1
DDR2
NoRC negatively regulates rRNA expression
CDK7
NOTCH1 Intracellular Domain Regulates Transcription
CDK8
NOTCH3 Activation and Transmission of Signal to the Nucleus
EGFR
NOTCH4 Intracellular Domain Regulates Transcription
FLT4
NPAS4 regulates expression of target genes
MAPK3
CDK5
PLK2
RET
NRAGE signals death through JNK
MAPK8
NRIF signals cell death from the nucleus
MAPK8
NTF3 activates NTRK2 (TRKB) signaling
NTRK2
NTF3 activates NTRK3 signaling
NTRK3
NTF4 activates NTRK2 (TRKB) signaling
NTRK2
NTRK2 activates RAC1
FYN
NTRK2
NTRK3 as a dependence receptor
NTRK3
Nuclear events mediated by NFE2L2
PRKAA2
Nuclear events stimulated by ALK signaling in cancer
MAPK3
STAT3
STAT5A
ZAP70
Nuclear Pore Complex (NPC) Disassembly
NEK6
NEK9
NEK7
Nuclear Receptor transcription pathway
RORC
Nuclear signaling by ERBB4
ERBB4
STAT5A
SRC
NVP-TAE684-resistant ALK mutants
ALK
Oncogene Induced Senescence
MAPK3
CDK6
CDK4
Orc1 removal from chromatin
CDK2
Other interleukin signaling
TYK2
CSF1R
JAK1
Ovarian tumor domain proteases
RIPK2
Oxidative Stress Induced Senescence
MAP2K4
MAPK3
MINK1
MAP2K7
MAPKAPK2
MAP2K6
MAPKAPK5
MAPK9
MAPK8
MAP2K3
MAPK10
TNIK
MAP3K5
MAP4K4
CDK6
CDK4
p130Cas linkage to MAPK signaling for integrins
PTK2
SRC
p38MAPK events
MAPK12
MAPKAPK2
SRC
MAPK13
p53-Dependent G1 DNA Damage Response
CDK2
p75NTR recruits signalling complexes
IRAK1
PRKCI
RIPK2
IKBKB
Paradoxical activation of RAF signaling by kinase inactive BRAF
MAPK3
MARK3
MAP2K1
JAK2
CSK
CAMK2B
MAP2K2
MAP3K11
CAMK2D
CAMK2G
SRC
CAMK2A
Pausing and recovery of HIV elongation
CDK9
Pausing and recovery of Tat-mediated HIV elongation
CDK9
PDE3B signalling
AKT2
PDGFR mutants bind TKIs
PDGFRA
PECAM1 interactions
LYN
YES1
FYN
LCK
SRC
pexidartinib-resistant FLT3 mutants
FLT3
Phase 0 - rapid depolarisation
CAMK2B
CAMK2D
CAMK2G
CAMK2A
Phase I - Functionalization of compounds
NQO2
Phospholipase C-mediated cascade: FGFR1
FGFR1
Phospholipase C-mediated cascade; FGFR2
FGFR2
Phospholipase C-mediated cascade; FGFR3
FGFR3
Phospholipase C-mediated cascade; FGFR4
FGFR4
Phosphorylation of CD3 and TCR zeta chains
CSK
LCK
Phosphorylation of Emi1
PLK1
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
CDK2
Phosphorylation of the APC/C
PLK1
Physiological factors
HIPK1
HIPK2
PI-3K cascade:FGFR1
FGFR1
PIK3CA
PI-3K cascade:FGFR2
PIK3CA
FGFR2
PI-3K cascade:FGFR3
PIK3CA
FGFR3
PI-3K cascade:FGFR4
PIK3CA
FGFR4
PI3K Cascade
PIK3CB
FGFR1
PIK3CA
FGFR2
FLT3
FGFR4
FGFR3
PI3K events in ERBB2 signaling
PIK3CA
ERBB4
EGFR
ERBB3
PI3K events in ERBB4 signaling
PIK3CA
ERBB4
PI3K/AKT activation
PIK3CB
PIK3CA
NTRK1
PI5P Regulates TP53 Acetylation
MAP2K6
PIP4K2B
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRAK1
MAPK3
PIK3CB
FGFR1
PIK3CD
PIK3CA
AKT1
PDGFRB
INSR
ERBB4
FGFR2
FLT3
IRAK4
PDGFRA
FGFR4
NTRK3
FYN
FGFR3
EGFR
MET
PIK3CG
ERBB3
PIP4K2B
PIP5K1A
LCK
SRC
NTRK2
KIT
PINK1-PRKN Mediated Mitophagy
TBK1
PIP3 activates AKT signaling
IRAK1
PIK3CB
FGFR1
PIK3CD
PIK3CA
AKT1
PDGFRB
AKT2
ERBB4
FGFR2
FLT3
IRAK4
PDGFRA
FGFR4
NTRK3
AKT3
FYN
FGFR3
EGFR
MET
PIK3CG
ERBB3
LCK
PDPK1
SRC
NTRK2
KIT
PKA activation
PRKACB
PRKACA
PKA activation in glucagon signalling
PRKACB
PRKACA
PKA-mediated phosphorylation of CREB
PRKX
PRKACB
PRKACA
PKA-mediated phosphorylation of key metabolic factors
PRKACB
PRKACA
PKR-mediated signaling
MAP2K6
STAT3
CHUK
IKBKB
EIF2AK2
Platelet Adhesion to exposed collagen
LYN
FYN
Platelet sensitization by LDL
FGR
PLC-gamma1 signalling
NTRK1
PLCG1 events in ERBB2 signaling
EGFR
Polo-like kinase mediated events
PLK1
WEE1
ponatinib-resistant FLT3 mutants
FLT3
Potential therapeutics for SARS
ROCK2
ROCK1
JAK2
JAK3
TYK2
JAK1
BTK
SYK
TBK1
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
STAT3
EPHA1
PPARA activates gene expression
CDK8
Pre-NOTCH Transcription and Translation
PRKCI
Presynaptic phase of homologous DNA pairing and strand exchange
CHEK1
Processing of DNA double-strand break ends
CHEK1
CDK2
Prolactin receptor signaling
JAK2
STAT5A
PTK6 Activates STAT3
PTK6
STAT3
PTK6 Down-Regulation
PTK6
SRMS
PTK6 Expression
PTK6
PTK6 promotes HIF1A stabilization
PTK6
EGFR
LRRK2
PTK6 Regulates Cell Cycle
PTK6
CDK2
CDK4
PTK6 Regulates Proteins Involved in RNA Processing
PTK6
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
PTK6
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
PTK6
AKT1
quizartinib-resistant FLT3 mutants
FLT3
RAB GEFs exchange GTP for GDP on RABs
AKT1
AKT2
ULK1
AKT3
RAC1 GTPase cycle
ABL2
PAK5
TAOK3
PIK3CA
PAK6
CDC42BPA
PAK2
PKN2
PAK3
PKN1
CIT
PAK4
PAK1
EPHA2
RAC2 GTPase cycle
TAOK3
PIK3CA
PAK2
PAK4
PAK1
EPHA2
RAC3 GTPase cycle
ABL2
TAOK3
PAK2
PAK4
PAK1
EPHA2
RAF activation
MARK3
MAP2K1
JAK2
CAMK2B
MAP2K2
MAP3K11
CAMK2D
CAMK2G
SRC
CAMK2A
RAF-independent MAPK1/3 activation
MAPK3
RAF/MAP kinase cascade
PTK2
MAPK3
PIK3CB
FGFR1
PIK3CA
PDGFRB
ERBB4
FGFR2
FLT3
PDGFRA
JAK2
FGFR4
JAK3
FYN
FGFR3
EGFR
MET
ERBB3
JAK1
CAMK2B
CAMK2D
TEK
RET
CAMK2G
CAMK2A
KIT
Rap1 signalling
PRKACB
PRKG1
PRKACA
Ras activation upon Ca2+ influx through NMDA receptor
CAMK2B
CAMK2D
CAMK2G
CAMK2A
RAS processing
PRKCQ
PRKG2
Receptor Mediated Mitophagy
ULK1
CSNK2A1
SRC
CSNK2A2
Receptor-type tyrosine-protein phosphatases
NTRK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
CHEK2
ABL1
MAPK8
Recruitment of mitotic centrosome proteins and complexes
PLK1
NEK2
PLK4
PRKACA
Recruitment of NuMA to mitotic centrosomes
PLK1
NEK2
PLK4
PRKACA
Recycling pathway of L1
RPS6KA3
RPS6KA5
RPS6KA2
RPS6KA1
RPS6KA6
RPS6KA4
SRC
Reelin signalling pathway
FYN
Regorafenib-resistant KIT mutants
KIT
Regorafenib-resistant PDGFR mutants
PDGFRA
Regulation of actin dynamics for phagocytic cup formation
PTK2
LIMK1
MAPK3
ABL1
BTK
SYK
PAK1
Regulation of activated PAK-2p34 by proteasome mediated degradation
PAK2
Regulation of APC/C activators between G1/S and early anaphase
CDK2
Regulation of commissural axon pathfinding by SLIT and ROBO
SRC
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
TESK1
Regulation of gap junction activity
SRC
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
PRKACB
PRKACA
Regulation of HSF1-mediated heat shock response
MAPK3
MAPKAPK2
GSK3B
Regulation of IFNA/IFNB signaling
TYK2
JAK1
Regulation of IFNG signaling
JAK2
JAK1
Regulation of innate immune responses to cytosolic DNA
TBK1
Regulation of insulin secretion
PRKACB
PRKACA
Regulation of KIT signaling
LYN
YES1
FYN
LCK
SRC
PRKCA
KIT
Regulation of localization of FOXO transcription factors
AKT1
AKT2
AKT3
Regulation of MECP2 expression and activity
CAMK4
CAMK2B
CAMK2D
CAMK2G
HIPK2
AURKB
CAMK2A
HTT
PRKACA
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
PLK1
MET
CDK2
Regulation of MITF-M-dependent genes involved in pigmentation
AKT2
Regulation of NF-kappa B signaling
CHUK
IKBKB
Regulation of PAK-2p34 activity by PS-GAP/RHG10
PAK2
Regulation of PLK1 Activity at G2/M Transition
PLK1
NEK2
AURKA
PLK4
PRKACA
Regulation of PTEN gene transcription
MAPK3
Regulation of PTEN stability and activity
AKT1
AKT2
TNKS2
FRK
CSNK2A1
AKT3
CSNK2A2
Regulation of pyruvate metabolism
NEK1
Regulation of RUNX1 Expression and Activity
SRC
CDK6
Regulation of RUNX2 expression and activity
GSK3B
Regulation of RUNX3 expression and activity
SRC
Regulation of signaling by CBL
LYN
PIK3CB
PIK3CD
PIK3CA
YES1
FYN
HCK
SYK
Regulation of signaling by NODAL
ACVR2B
ACVR2A
ACVR1B
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
IKBKE
TBK1
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
IKBKE
TBK1
Regulation of the apoptosome activity
MAPK3
Regulation of TNFR1 signaling
MAPKAPK2
ULK1
IKBKE
TBK1
CHUK
IKBKB
Regulation of TP53 Activity through Acetylation
AKT1
AKT2
AKT3
Regulation of TP53 Activity through Association with Co-factors
AKT1
AKT2
AKT3
Regulation of TP53 Activity through Methylation
CHEK2
Regulation of TP53 Activity through Phosphorylation
PRKAG2
STK11
CHEK2
CHEK1
PRKAA1
CDK5
MAPKAPK5
PLK3
AURKA
HIPK1
DYRK2
PRKAA2
CSNK2A1
CDK2
NUAK1
HIPK2
AURKB
CSNK2A2
PRKAG1
Regulation of TP53 Degradation
CHEK2
AKT1
AKT2
AKT3
CDK2
PDPK1
Replacement of protamines by nucleosomes in the male pronucleus
SRPK1
Resolution of Sister Chromatid Cohesion
PLK1
TAOK1
AURKB
Respiratory syncytial virus (RSV) attachment and entry
EGFR
IGF1R
Response of EIF2AK4 (GCN2) to amino acid deficiency
EIF2AK4
Response to elevated platelet cytosolic Ca2+
PRKCA
RET signaling
PIK3CB
PIK3CD
PIK3CA
PRKACB
MAPK7
RET
SRC
PRKCA
PRKACA
Retrograde neurotrophin signalling
NTRK1
RHO GTPases activate CIT
CIT
RHO GTPases Activate Formins
PLK1
TAOK1
AURKB
SRC
RHO GTPases Activate NADPH Oxidases
MAPK3
PRKCD
PRKCA
RHO GTPases activate PAKs
LIMK1
PAK2
MYLK
PAK3
PAK1
RHO GTPases activate PKNs
PKN2
PKN3
PDPK1
PKN1
PAK1
RHO GTPases Activate ROCKs
LIMK1
ROCK2
ROCK1
PAK1
RHO GTPases Activate WASPs and WAVEs
PTK2
MAPK3
ABL1
BTK
RHOA GTPase cycle
ROCK2
STK10
ROCK1
PKN2
PKN3
SLK
PKN1
CIT
RHOB GTPase cycle
ROCK2
STK10
ROCK1
PKN2
PKN3
SLK
PKN1
CIT
RHOBTB1 GTPase cycle
ROCK2
ROCK1
STK38
RHOBTB2 GTPase cycle
STK38
RHOC GTPase cycle
ROCK2
STK10
ROCK1
PKN2
PKN3
SLK
PKN1
CIT
RHOD GTPase cycle
PAK5
PAK6
RHOG GTPase cycle
PAK2
MAP3K11
PAK4
EPHA2
RHOH GTPase cycle
ROCK2
PAK5
ROCK1
PAK6
CSK
PAK2
ZAP70
LCK
PAK4
PAK1
RHOJ GTPase cycle
CDC42BPB
CDC42BPA
PAK2
PAK3
PAK4
PAK1
RHOQ GTPase cycle
CDC42BPB
CDC42BPA
PAK2
PAK4
PAK1
RHOU GTPase cycle
PAK2
PTK2B
PAK3
SRC
PAK4
PAK1
EPHA2
RHOV GTPase cycle
PAK6
PAK2
MAP3K11
PAK4
PAK1
EPHA2
RIP-mediated NFkB activation via ZBP1
CHUK
IKBKB
RMTs methylate histone arginines
JAK2
CDK4
RNA Pol II CTD phosphorylation and interaction with CE
CDK7
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
CDK7
RNA Polymerase I Promoter Escape
CDK7
RNA Polymerase I Promoter Opening
MAPK3
RNA Polymerase I Transcription Initiation
CDK7
RNA Polymerase I Transcription Termination
CDK7
RNA Polymerase II HIV Promoter Escape
CDK7
RNA Polymerase II Pre-transcription Events
CDK9
CDK7
RNA Polymerase II Promoter Escape
CDK7
RNA polymerase II transcribes snRNA genes
CDK9
CDK7
RNA Polymerase II Transcription Elongation
CDK9
CDK7
RNA Polymerase II Transcription Initiation
CDK7
RNA Polymerase II Transcription Initiation And Promoter Clearance
CDK7
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
CDK7
RND1 GTPase cycle
EPHA2
RND2 GTPase cycle
EPHA2
RND3 GTPase cycle
ROCK1
EPHA2
ROBO receptors bind AKAP5
PRKACB
PRKCA
PRKACA
Role of ABL in ROBO-SLIT signaling
ABL2
ABL1
Role of LAT2/NTAL/LAB on calcium mobilization
LYN
PIK3CB
PIK3CA
FYN
SYK
PDPK1
Role of phospholipids in phagocytosis
PIK3CB
PRKCD
PIK3CA
PRKCE
SYK
RSK activation
MAPK3
RPS6KA3
RPS6KA2
RPS6KA1
RPS6KA6
PDPK1
RSV-host interactions
CDK8
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
CSNK2A1
HIPK2
CSNK2A2
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
PRKCQ
RUNX1 regulates transcription of genes involved in BCR signaling
BLK
RUNX1 regulates transcription of genes involved in differentiation of HSCs
ABL1
CDK7
RUNX2 regulates genes involved in cell migration
AKT1
AKT2
AKT3
RUNX2 regulates osteoblast differentiation
MAPK3
YES1
ABL1
SRC
RUNX3 Regulates Immune Response and Cell Migration
RORC
SARS-CoV-1 activates/modulates innate immune responses
IKBKE
TBK1
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
PDPK1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1
MAP3K7
TYK2
JAK1
IKBKE
CHUK
RIPK2
IKBKB
TBK1
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
AKT1
AKT2
AKT3
PDPK1
SCF(Skp2)-mediated degradation of p27/p21
PTK6
CDK2
CDK4
Sema3A PAK dependent Axon repulsion
LIMK1
FES
FYN
PAK2
PAK3
PAK1
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
FES
FYN
Sema4D induced cell migration and growth-cone collapse
LIMK1
ROCK2
ROCK1
Sema4D mediated inhibition of cell attachment and migration
MET
semaxanib-resistant FLT3 mutants
FLT3
Senescence-Associated Secretory Phenotype (SASP)
MAPK3
RPS6KA3
STAT3
RPS6KA2
RPS6KA1
CDK2
MAPK7
CDK6
CDK4
Sensory processing of sound by inner hair cells of the cochlea
MYO3B
CASK
MYO3A
Sensory processing of sound by outer hair cells of the cochlea
MYO3B
CASK
MYO3A
Separation of Sister Chromatids
PLK1
TAOK1
AURKB
SHC-mediated cascade:FGFR1
FGFR1
SHC-mediated cascade:FGFR2
FGFR2
SHC-mediated cascade:FGFR3
FGFR3
SHC-mediated cascade:FGFR4
FGFR4
SHC-related events triggered by IGF1R
IGF1R
SHC1 events in EGFR signaling
EGFR
SHC1 events in ERBB2 signaling
PRKCD
PRKCE
ERBB4
EGFR
ERBB3
PRKCA
SHC1 events in ERBB4 signaling
ERBB4
Signal attenuation
MAPK3
INSR
Signal regulatory protein family interactions
PTK2
PTK2B
SRC
Signal transduction by L1
MAPK3
FGFR1
MAP2K1
EGFR
MAP2K2
CSNK2A1
CSNK2A2
PAK1
Signaling by activated point mutants of FGFR1
FGFR1
Signaling by activated point mutants of FGFR3
FGFR3
Signaling by Activin
MAPK3
ACVR2B
ACVR2A
ACVR1B
Signaling by ALK
ALK
PIK3CB
PIK3CA
STAT3
JAK3
SRC
Signaling by ALK fusions and activated point mutants
ALK
PIK3CB
PIK3CA
STAT3
MAPK9
MAPK8
TYK2
Signaling by BMP
BMPR2
BMPR1A
BMPR1B
ACVR2B
ACVR2A
ACVRL1
Signaling by BRAF and RAF1 fusions
MAPK3
MARK3
MAP2K1
JAK2
CSK
CAMK2B
MAP2K2
CAMK2D
CAMK2G
SRC
CAMK2A
Signaling by CSF1 (M-CSF) in myeloid cells
LYN
PIK3CB
PIK3CD
PIK3CA
STAT3
YES1
FYN
CSF1R
HCK
SRC
Signaling by CSF3 (G-CSF)
LYN
STAT3
JAK2
TYK2
STAT5A
JAK1
HCK
SYK
Signaling by cytosolic FGFR1 fusion mutants
PIK3CA
STAT3
STAT5A
Signaling by EGFR
EGFR
SRC
Signaling by ERBB2
ERBB4
YES1
FYN
EGFR
ERBB3
SRC
Signaling by ERBB2 ECD mutants
PIK3CA
EGFR
Signaling by ERBB2 KD Mutants
PIK3CA
EGFR
ERBB3
ERBB4
Signaling by ERBB2 TMD/JMD mutants
EGFR
ERBB3
ERBB4
Signaling by ERBB4
ERBB4
EGFR
ERBB3
Signaling by Erythropoietin
LYN
JAK2
Signaling by extracellular domain mutants of KIT
KIT
Signaling by FGFR1 amplification mutants
FGFR1
Signaling by FGFR1 in disease
FGFR1
PIK3CA
Signaling by FGFR2 amplification mutants
FGFR2
Signaling by FGFR2 fusions
FGFR2
Signaling by FGFR2 IIIa TM
FGFR2
Signaling by FGFR2 in disease
PIK3CA
FGFR2
Signaling by FGFR3 fusions in cancer
FGFR3
Signaling by FGFR3 in disease
PIK3CA
FGFR3
Signaling by FGFR4 in disease
PIK3CA
FGFR4
Signaling by FLT3 fusion proteins
PIK3CA
STAT5A
PIM1
Signaling by FLT3 ITD and TKD mutants
PIK3CA
FLT3
Signaling by GSK3beta mutants
GSK3B
Signaling by high-kinase activity BRAF mutants
MAPK3
MARK3
MAP2K1
CSK
MAP2K2
SRC
Signaling by Hippo
LATS2
STK3
LATS1
STK4
Signaling by Insulin receptor
INSR
Signaling by juxtamembrane domain KIT mutants
KIT
Signaling by kinase domain mutants of KIT
KIT
Signaling by Leptin
STAT3
JAK2
STAT5A
Signaling by LTK
LTK
TNK2
PIK3CB
PIK3CA
Signaling by LTK in cancer
MAPK3
PIK3CB
PIK3CA
Signaling by MAP2K mutants
MAPK3
MAP2K1
MAP2K2
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
KDR
Signaling by moderate kinase activity BRAF mutants
MAPK3
MARK3
MAP2K1
JAK2
CSK
CAMK2B
MAP2K2
MAP3K11
CAMK2D
CAMK2G
SRC
CAMK2A
Signaling by MST1
MST1R
Signaling by NODAL
MAPK3
ACVR2B
ACVR2A
ACVR1B
Signaling by NTRK3 (TRKC)
NTRK3
Signaling by PDGF
PDGFRB
PDGFRA
Signaling by PDGFRA extracellular domain mutants
PIK3CB
PIK3CA
STAT3
PDGFRA
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
PIK3CB
PIK3CA
STAT3
PDGFRA
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
LYN
PIK3CA
STAT3
YES1
JAK2
FYN
STAT5A
LCK
SRC
KIT
Signaling by plasma membrane FGFR1 fusions
FGFR1
Signaling by RAF1 mutants
MAPK3
MARK3
MAP2K1
JAK2
CSK
CAMK2B
MAP2K2
CAMK2D
CAMK2G
SRC
CAMK2A
Signaling by SCF-KIT
LYN
CHEK1
PIK3CA
STAT3
YES1
FES
JAK2
TEC
FYN
STAT5A
FER
LCK
SRC
PRKCA
KIT
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IGF1R
Signaling downstream of RAS mutants
MAPK3
MARK3
MAP2K1
JAK2
CSK
CAMK2B
MAP2K2
MAP3K11
CAMK2D
CAMK2G
SRC
CAMK2A
Signalling to ERK5
MAP2K5
MAPK7
Signalling to p38 via RIT and RIN
NTRK1
Signalling to RAS
NTRK1
Signalling to STAT3
STAT3
NTRK1
SLC15A4:TASL-dependent IRF5 activation
CHUK
IKBKB
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2
TGFBR1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
MAPK3
CDK9
CDK8
Smooth Muscle Contraction
PAK2
MYLK
PAK1
Somitogenesis
EPHA4
sorafenib-resistant FLT3 mutants
FLT3
Sorafenib-resistant KIT mutants
KIT
Sorafenib-resistant PDGFR mutants
PDGFRA
Sphingolipid de novo biosynthesis
PRKD3
PRKD2
PRKD1
Spry regulation of FGF signaling
MAPK3
MKNK1
SRC
Stabilization of p53
CHEK2
STAT3 nuclear events downstream of ALK signaling
STAT3
STAT5 Activation
FLT3
STAT5A
STAT5 activation downstream of FLT3 ITD mutants
FLT3
STAT5A
PIM1
STAT6-mediated induction of chemokines
TBK1
Stimulation of the cell death response by PAK-2p34
PAK2
Stimuli-sensing channels
SGK3
SUMOylation of DNA replication proteins
AURKA
AURKB
SUMOylation of immune response proteins
IKBKE
EIF2AK2
SUMOylation of transcription cofactors
HIPK2
sunitinib-resistant FLT3 mutants
FLT3
Sunitinib-resistant KIT mutants
KIT
Sunitinib-resistant PDGFR mutants
PDGFRA
Suppression of apoptosis
MAPK3
GSK3A
Syndecan interactions
PRKCA
CASK
Synthesis of Leukotrienes (LT) and Eoxins (EX)
MAPKAPK2
Synthesis of PC
CSNK2A1
CSNK2A2
Synthesis of PIPs at the Golgi membrane
PIK3C2G
PI4KB
Synthesis of PIPs at the plasma membrane
BMX
PIK3CB
PIK3CD
PIK3CA
PIK3C2G
PIK3CG
PIP4K2B
PIK3C2B
PIP5K1A
Synthesis of PIPs in the nucleus
PIP4K2B
t(4;14) translocations of FGFR3
FGFR3
TAK1-dependent IKK and NF-kappa-B activation
IRAK1
MAP3K7
RIPK2
CHUK
IKBKB
tamatinib-resistant FLT3 mutants
FLT3
tandutinib-resistant FLT3 mutants
FLT3
Tat-mediated elongation of the HIV-1 transcript
CDK9
CDK7
Tat-mediated HIV elongation arrest and recovery
CDK9
TBC/RABGAPs
ULK1
TCF dependent signaling in response to WNT
TNKS2
Telomere Extension By Telomerase
CDK2
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
AKT1
PRKG2
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
EGFR
KIT
TGF-beta receptor signaling activates SMADs
TGFBR2
TGFBR1
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR2
TGFBR1
TGFBR1 KD Mutants in Cancer
TGFBR2
TGFBR1
TGFBR1 LBD Mutants in Cancer
TGFBR2
TGFBR1
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR2
TGFBR1
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2
TGFBR3 regulates activin signaling
ACVR2A
TGFBR3 regulates TGF-beta signaling
TGFBR2
TGFBR1
The role of GTSE1 in G2/M progression after G2 checkpoint
PLK1
Thrombin signalling through proteinase activated receptors (PARs)
MAPK3
SRC
TICAM1, RIP1-mediated IKK complex recruitment
CHUK
IKBKB
TICAM1,TRAF6-dependent induction of TAK1 complex
MAP3K7
TICAM1-dependent activation of IRF3/IRF7
IKBKE
TBK1
Tie2 Signaling
PIK3CB
PIK3CA
TEK
Tight junction interactions
PRKCI
TNFR1-induced NF-kappa-B signaling pathway
MAP3K7
CHUK
IKBKB
TNFR1-induced proapoptotic signaling
IKBKE
TBK1
TP53 Regulates Metabolic Genes
PRKAG2
PRKAA1
AKT1
AKT2
AKT3
PRKAA2
PRKAG1
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
PLK3
PLK2
TP53 Regulates Transcription of DNA Repair Genes
CHEK1
CDK9
CDK13
CDK7
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDK2
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
AURKA
TRAF3-dependent IRF activation pathway
IKBKE
TBK1
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1
IRAK4
MAP3K1
TRAF6 mediated IRF7 activation
IKBKE
TBK1
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1
IRAK4
TRAF6 mediated NF-kB activation
MAP3K1
CHUK
IKBKB
TRAF6-mediated induction of TAK1 complex within TLR4 complex
MAP3K7
Trafficking of AMPA receptors
CAMK2B
CAMK2D
CAMK2G
CAMK2A
Trafficking of GluR2-containing AMPA receptors
PRKCA
Transcription of the HIV genome
CDK7
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
CDK7
Transcriptional activation of mitochondrial biogenesis
CAMK4
Transcriptional and post-translational regulation of MITF-M expression and activity
MAPK3
MARK3
RPS6KA1
AKT3
GSK3B
KIT
Transcriptional Regulation by E2F6
CHEK1
Transcriptional Regulation by MECP2
IRAK1
Transcriptional regulation by RUNX2
CDK4
Transcriptional Regulation by VENTX
CSF1R
Transcriptional regulation of granulopoiesis
STAT3
CDK2
CDK4
Transcriptional regulation of pluripotent stem cells
STAT3
Transcriptional regulation of white adipocyte differentiation
CDK4
CDK8
Translocation of SLC2A4 (GLUT4) to the plasma membrane
PRKAG2
AKT1
AKT2
PRKAA2
PRKAG1
Translocation of ZAP-70 to Immunological synapse
ZAP70
LCK
Triglyceride catabolism
PRKACB
PRKACA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
MAPKAPK2
TRKA activation by NGF
NTRK1
Truncations of AMER1 destabilize the destruction complex
GSK3B
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
PTK2
ABL1
IKBKE
CHUK
IKBKB
Ub-specific processing proteases
MAP3K7
TNKS2
TGFBR1
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
CHEK2
CHEK1
Ubiquitin-dependent degradation of Cyclin D
GSK3B
CDK4
UCH proteinases
TGFBR2
TGFBR1
Unblocking of NMDA receptors, glutamate binding and activation
CAMK2B
CAMK2D
CAMK2G
CAMK2A
Uptake and function of anthrax toxins
MAP2K4
MAP2K7
MAP2K6
MAP2K1
MAP2K3
MAP2K2
Vasopressin regulates renal water homeostasis via Aquaporins
PRKACB
PRKACA
VEGF binds to VEGFR leading to receptor dimerization
FLT1
FLT4
KDR
VEGFA-VEGFR2 Pathway
PTK2
MAPK12
ROCK2
PIK3CB
MAPKAPK2
PIK3CA
ROCK1
AXL
PRKACB
FYN
PAK2
PTK2B
SRC
KDR
MAPK13
PRKACA
VEGFR2 mediated cell proliferation
PRKCD
PDPK1
SRC
PRKCA
KDR
VEGFR2 mediated vascular permeability
AKT1
AKT2
AKT3
PAK2
PAK3
PDPK1
PAK1
WNT mediated activation of DVL
CSNK2A1
CSNK2A2
WNT5:FZD7-mediated leishmania damping
MAPK8
WNT5A-dependent internalization of FZD4
PRKCA
XAV939 stabilizes AXIN
TNKS2
XBP1(S) activates chaperone genes
GSK3A
YAP1- and WWTR1 (TAZ)-stimulated gene expression
HIPK1
HIPK2
21
2023
Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2.
Amrhein JA, Wang G et al. ACS Med Chem Lett
2023
Deciphering the multifunctional role of dual leucine zipper kinase (DLK) and its therapeutic potential in disease.
Bu H, Li Z et al. Eur J Med Chem
2022
Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemia.
Dokla EME, Abdel-Aziz AK et al. Bioorg Med Chem
2022
FLT3 inhibitors for acute myeloid leukemia: successes, defeats, and emerging paradigms.
Acharya B, Saha D et al. RSC Med Chem
2022
Dual-target Janus kinase (JAK) inhibitors: Comprehensive review on the JAK-based strategies for treating solid or hematological malignancies and immune-related diseases.
Shen P, Wang Y et al. Eur J Med Chem
2022
ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders.
Demuro S, Sauvey C et al. Eur J Med Chem
2022
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
Raghuvanshi R, Bharate SB. J Med Chem
Screening of ~5500 FDA-approved drugs and clinical candidates for anti-SARS-CoV-2 activity (dataset)
2020
Discovery of orally active indirubin-3'-oxime derivatives as potent type 1 FLT3 inhibitors for acute myeloid leukemia.
Jeong P,Moon Y et al. Eur J Med Chem
2020
Small-Molecule Fms-like Tyrosine Kinase 3 Inhibitors: An Attractive and Efficient Method for the Treatment of Acute Myeloid Leukemia.
Zhong Y, Qiu RZ et al. J Med Chem
2017
The target landscape of clinical kinase drugs.
Klaeger S, Heinzlmeir S and Wilhelm M et al Science
2013
Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.
Goodfellow VS, Loweth CJ et al. J. Med. Chem.
2012
Inhibitors of Stat5 protein signalling
Cumaraswamy AA, Todic A et al. MedChemComm
2011
Comprehensive analysis of kinase inhibitor selectivity.
Davis MI, Hunt JP et al. Nat. Biotechnol.
2009
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).
Zarrinkar PP, Gunawardane RN et al. Blood
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute (dataset)
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Purified N370S Glucocerebrosidase. (Class of assay: confirmatory) [Related pubchem assays: 2101 ]
AID 2597
PKIDB (dataset)
569
0
15
Cayman Chemical Bioactives
ChEMBL Drugs
Clinical kinase drugs
DrugBank
DrugMAP
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Nuisance compounds in cellular assays
Obsolete Compounds
PKIDB
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
Welcome Trust Cancer Drugs
4
Cayman Chemical Bioactives
MedChem Express Bioactive Compound Library
36
ChEMBL CHEMBL603469
GtoPdb 5672
PubChem 126565
ZINC ZINC000003781738
ACToR 111358-88-4
BindingDB 50308060
Brenda 27072
ChEBI 91471
ChemicalBook CB3506750
ChemSpider 112457
COCONUT CNP0527731.1
CompTox DTXSID5046778
DrugBank DB06469
FDA SRS DO989GC5D1
GSRS 10797da6-df66-4...
IBM NIH E78707620264CCB...
LINCS LSM-1231
PDB 2V9
PubChem DOTF 26683764
PubChem TPS 14881395
Reactome 112457
SureChEMBL SCHEMBL1649693
(calculated by RDKit )
Molecular Weight
439.15
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
8
Aromatic Ring Count
5
cLogP
3.47
TPSA
88.65
Fraction CSP3
0.27
Chiral centers
3.0
Largest ring
7.0
QED
0.37
2
historic compounds (Chemical Probes.org)
Obsolete
Nonspecific kinase inhibition
Nuisance compounds
(extracted from source data)
Pathway
RTK signaling
Apoptosis
Epigenetics
JAK/STAT Signaling
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
Target
FLT3, JAK2, NTRK1, RET
FLT3
JAK
STAT
Trk Receptor
Targets
JAK2,FLT3,NTRK1
Cellular injury category
Kinase
Therapeutic Class
Anticancer Agents