General
Preferred name
LESTAURTINIB
Synonyms
CEP-701 ()
CEP-701, SP-924, KT-555, SP924, KT-5555, A-1544750, SPM-924, A-154475 ()
KT-5555 ()
A-154475 ()
A-154475.0 ()
KT-555 ()
KT5555 ()
SP-924 ()
SP924 ()
SPM-924 ()
Cep-701 ()
P&D ID
PD019262
CAS
111358-88-4
Tags
available
nuisance
obsolete probe
drug candidate
Drug indication
Acute myeloid leukaemia
Psoriasis vulgaris
Myeloid leukaemia
Drug Status
investigational
Max Phase
3.0
Structure
PD019262
LESTAURTINIB
nuisance obsolete probe
RO5
MW
439.15
HBA
6
HBD
3
RB
1
LOGP
3.47
13
15
2
357
Structure formats
SMILES
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O
InChI
InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1
InChIkey
UIARLYUEJFELEN-LROUJFHJSA-N
MOL
LESTAURTINIB RDKit 2D 33 40 0 0 0 0 0 0 0 0999 V2000 3.4199 -7.0384 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5382 -5.8249 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2490 -4.5040 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.6595 -3.1247 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0638 -3.6517 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9965 -5.1502 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2423 -6.6300 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.4938 -5.0605 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3202 -6.3124 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2135 -2.7256 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 0.7500 -1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7500 1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.7500 1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.7500 -1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.2135 -2.7256 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.5518 -3.5691 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.6191 -5.0676 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.3550 -5.8751 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.0212 -7.3375 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.8846 -8.5641 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.2541 -9.9251 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.2399 -10.0596 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1033 -8.8330 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.4728 -7.4720 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0623 -6.0927 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 -0.0673 -5.1058 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.0000 -3.6073 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.0650 -5.4667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.8913 -4.2148 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 -3.9561 -3.0421 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.3552 -1.5961 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2 1 1 6 2 3 1 0 3 4 1 0 4 5 1 1 5 6 1 0 6 7 1 1 6 8 1 0 8 9 1 0 4 10 1 0 10 11 1 0 11 12 2 0 12 13 1 0 13 14 2 0 14 15 1 0 15 16 2 0 16 17 1 0 17 18 2 0 18 19 1 0 19 20 2 0 20 21 1 0 21 22 2 0 22 23 1 0 23 24 2 0 24 25 1 0 25 26 2 0 26 27 1 0 27 28 1 0 28 29 2 0 19 30 1 0 30 31 1 0 31 32 1 0 32 33 2 0 6 2 1 0 29 10 1 0 27 2 1 0 16 11 1 0 29 17 1 0 32 18 1 0 28 20 1 0 26 21 1 0 M END > <ID> PD019262 > <Name> LESTAURTINIB
Description
(extracted from source data)
DESCRIPTION Lestaurtinib was identified as an inhibitor of the receptor tyrosine kinase (RTK) FLT3 (fms-related tyrosine kinase 3) with activity against leukemia cells in vitro and in vivo . It has activity against other RTKs. A drug repurposing sceen for breast cancer has identified lestaurtinib as a promising agent which appears to sensitise BRCA mutant and wild type breast cancer cells to the effects of the Poly (ADP-ribose) polymerase 1 (PARP1) inhibitor . (GtoPdb)
Protein targets
357
9.41
PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform BIOCHEM 1.4x
1
2
9.28
MAP3K19 Mitogen-activated protein kinase kinase kinase 19
0
2
9
LATS2 Serine/threonine-protein kinase LATS2 inhibitor
1
2
9
NUAK2 NUAK family SNF1-like kinase 2
0
3
8.85
MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2
0
2
8.82
PLK4 Serine/threonine-protein kinase PLK4
7
3
8.77
8
JAK2 Tyrosine-protein kinase JAK2
38
6
8.77
PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
1
3
8.74
PKN2 Serine/threonine-protein kinase N2
6
3
8.64
JAK3 Tyrosine-protein kinase JAK3
11
2
8.62
STK3 Serine/threonine-protein kinase 3
1
3
8.55
CHEK1 Serine/threonine-protein kinase Chk1
10
3
8.54
MAP3K7 Mitogen-activated protein kinase kinase kinase 7
18
2
8.52
LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2
1
1
8.52
CLK4 Dual specificity protein kinase CLK4
0
2
8.52
STK4 Serine/threonine-protein kinase 4
1
3
8.51
AAK1 AP2-associated protein kinase 1
2
3
8.47
PDPK1 3-phosphoinositide-dependent protein kinase 1
20
2
8.47
STK17A Serine/threonine-protein kinase 17A
0
2
8.47
MAP3K15 Mitogen-activated protein kinase kinase kinase 15
0
2
8.46
MAP3K9 Mitogen-activated protein kinase kinase kinase 9
0
2
8.46
MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1
15
3
8.44
MINK1 Misshapen-like kinase 1
1
3
8.43
NUAK1 NUAK family SNF1-like kinase 1
1
2
8.42
MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4
5
3
8.41
MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2
14
3
8.39
EIF2AK4 eIF-2-alpha kinase GCN2
1
2
8.39
AURKC Aurora kinase C
0
2
8.33
MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2
0
3
8.32
MAP3K2 Mitogen-activated protein kinase kinase kinase 2
0
3
8.31
ULK3 Serine/threonine-protein kinase ULK3
1
3
8.31
MAPK15 Mitogen-activated protein kinase 15
0
2
8.3
STK17B Serine/threonine-protein kinase 17B
0
2
8.3
MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3
3
3
8.28
PKN1 Serine/threonine-protein kinase N1
6
3
8.28
DSTYK Dual serine/threonine and tyrosine protein kinase
0
1
8.27
TNIK Traf2 and NCK-interacting protein kinase
1
2
8.25
CDPK1 Calcium-dependent protein kinase 1
0
1
8.24
SGK3 Serine/threonine-protein kinase Sgk3
1
1
8.24
ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1
1
3
8.24
STK10 Serine/threonine-protein kinase 10
4
3
8.22
MAP3K3 Mitogen-activated protein kinase kinase kinase 3
1
3
8.21
IRAK1 Interleukin-1 receptor-associated kinase 1
18
2
8.19
TTK Dual specificity protein kinase TTK
0
2
8.18
TNKS2 Poly [ADP-ribose] polymerase tankyrase-2
5
1
8.14
GAK Cyclin-G-associated kinase
2
3
8.14
GRK7 Rhodopsin kinase GRK7
1
2
8.11
RIOK3 Serine/threonine-protein kinase RIO3
1
2
8.09
PRKD2 Serine/threonine-protein kinase D2
1
3
8.08
NTRK1 High affinity nerve growth factor receptor
10
3
8.07
8.6
FLT3 Receptor-type tyrosine-protein kinase FLT3 inhibitor CELL-BASED 4x
27
12
8.06
CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta
20
3
8.06
JAK1 Tyrosine-protein kinase JAK1
29
2
8.05
CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha
31
2
8.05
RIOK1 Serine/threonine-protein kinase RIO1
1
2
8.05
PRKD3 Serine/threonine-protein kinase D3
1
3
8.03
TNK1 Non-receptor tyrosine-protein kinase TNK1
0
3
8.02
SYK Tyrosine-protein kinase SYK
21
3
8.02
CLK1 Dual specificity protein kinase CLK1
0
3
8
PAK6 Serine/threonine-protein kinase PAK 6
6
2
8
SRPK1 SRSF protein kinase 1
2
2
8
CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha
21
2
8
CDKL5 Cyclin-dependent kinase-like 5
0
2
8
STAT5A Signal transducer and activator of transcription 5A
22
1
8
STAT3 Signal transducer and activator of transcription 3
38
1
7.96
IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon
13
3
7.96
MAPK8 Mitogen-activated protein kinase 8
12
3
7.92
IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta
29
2
7.92
GRK4 G protein-coupled receptor kinase 4
1
2
7.92
MAPK10 Mitogen-activated protein kinase 10
4
3
7.91
IRAK4 Interleukin-1 receptor-associated kinase 4
10
2
7.89
SRPK3 SRSF protein kinase 3
0
2
7.89
MYLK Myosin light chain kinase, smooth muscle
2
2
7.89
RIPK4 Receptor-interacting serine/threonine-protein kinase 4
0
2
7.85
MARK2 Serine/threonine-protein kinase MARK2
0
3
7.85
RET Proto-oncogene tyrosine-protein kinase receptor Ret
5
3
7.85
NTRK3 NT-3 growth factor receptor
10
2
7.85
NTRK2 BDNF/NT-3 growth factors receptor
14
2
7.85
PRKD1 Serine/threonine-protein kinase D1
1
2
7.82
SIK2 Serine/threonine-protein kinase SIK2
0
3
7.82
CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2
4
3
7.82
MAP3K10 Mitogen-activated protein kinase kinase kinase 10
0
2
7.8
BMP2K BMP-2-inducible protein kinase
0
3
7.8
BRSK2 Serine/threonine-protein kinase BRSK2
0
2
7.8
AURKB Aurora kinase B
10
3
7.8
IRAK3 Interleukin-1 receptor-associated kinase 3
2
3
7.8
ZAP70 Tyrosine-protein kinase ZAP-70
4
2
7.8
AURKA Aurora kinase A
8
3
7.77
FLT4 Vascular endothelial growth factor receptor 3
3
2
7.75
TBK1 Serine/threonine-protein kinase TBK1
19
3
7.75
MAP3K11 Mitogen-activated protein kinase kinase kinase 11
7
4
7.75
PIP4K2B Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
4
2
7.75
PIM3 Serine/threonine-protein kinase pim-3
0
2
7.72
STK16 Serine/threonine-protein kinase 16
0
2
7.72
MAST1 Microtubule-associated serine/threonine-protein kinase 1
0
2
7.7
CDK2 Cyclin-dependent kinase 2
27
3
7.7
7.92
DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A
1
4
7.68
TNK2 Activated CDC42 kinase 1
1
2
7.66
DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2
1
2
7.64
CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1
3
2
7.64
MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4
1
3
7.62
PAK5 Serine/threonine-protein kinase PAK 5
5
2
7.62
PAK4 Serine/threonine-protein kinase PAK 4
11
3
7.62
GRK1 Rhodopsin kinase GRK1
1
2
7.6
BRSK1 Serine/threonine-protein kinase BRSK1
0
2
7.6
PRKG2 cGMP-dependent protein kinase 2
4
2
7.6
PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1
5
3
7.58
MELK Maternal embryonic leucine zipper kinase
0
3
7.58
ROS1 Proto-oncogene tyrosine-protein kinase ROS
0
2
7.58
STK33 Serine/threonine-protein kinase 33
0
2
7.57
CDK16 Cyclin-dependent kinase 16
0
2
7.55
FER Tyrosine-protein kinase Fer
1
3
7.54
MYLK4 Myosin light chain kinase family member 4
0
2
7.54
DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B
0
2
7.54
PDGFRB Platelet-derived growth factor receptor beta
6
3
7.52
LATS1 Serine/threonine-protein kinase LATS1 inhibitor
1
3
7.52
PAK1 Serine/threonine-protein kinase PAK 1
26
2
7.5
MERTK Tyrosine-protein kinase Mer
1
2
7.5
ANKK1 Ankyrin repeat and protein kinase domain-containing protein 1
0
2
7.47
MYLK3 Myosin light chain kinase 3
0
2
7.46
CDK4 Cyclin-dependent kinase 4
18
2
7.46
AXL Tyrosine-protein kinase receptor UFO
1
2
7.46
PAK3 Serine/threonine-protein kinase PAK 3
13
2
7.46
SLK STE20-like serine/threonine-protein kinase
3
3
7.44
PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
2
2
7.42
MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1
0
3
7.41
CILK1 Serine/threonine-protein kinase ICK
0
2
7.39
PTK2B Protein-tyrosine kinase 2-beta
4
3
7.38
PRKX cAMP-dependent protein kinase catalytic subunit PRKX
4
3
7.37
CDKL2 Cyclin-dependent kinase-like 2
0
2
7.37
PAK2 Serine/threonine-protein kinase PAK 2
27
2
7.37
MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5
0
3
7.36
MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6
8
3
7.36
CLK2 Dual specificity protein kinase CLK2
0
2
7.35
KIT Mast/stem cell growth factor receptor Kit
20
2
7.33
CAMK1D Calcium/calmodulin-dependent protein kinase type 1D
0
2
7.31
MARK3 MAP/microtubule affinity-regulating kinase 3
10
3
7.29
SRPK2 SRSF protein kinase 2
1
2
7.28
FGR Tyrosine-protein kinase Fgr
5
2
7.26
PKNB Serine/threonine-protein kinase PknB
0
1
7.25
MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1
1
2
7.25
ROCK1 Rho-associated protein kinase 1
15
2
7.25
PRKAA2 5'-AMP-activated protein kinase catalytic subunit alpha-2
11
2
7.25
MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle
0
2
7.24
STK11 Serine/threonine-protein kinase STK11
4
2
7.24
BMPR1B Bone morphogenetic protein receptor type-1B
1
2
7.23
CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta
21
2
7.22
ULK2 Serine/threonine-protein kinase ULK2
0
2
7.2
DAPK2 Death-associated protein kinase 2
1
2
7.19
TLK2 Serine/threonine-protein kinase tousled-like 2
0
2
7.18
BTK Tyrosine-protein kinase BTK
14
3
7.16
MAP3K5 Mitogen-activated protein kinase kinase kinase 5
1
3
7.16
TAOK1 Serine/threonine-protein kinase TAO1
6
2
7.15
ROCK2 Rho-associated protein kinase 2
12
2
7.15
ALK ALK tyrosine kinase receptor
11
2
7.12
ACVR1 Activin receptor type-1
0
3
7.1
DAPK1 Death-associated protein kinase 1
1
2
7.1
Uncharacterized protein FLJ45252
0
1
7.1
MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7
4
1
7.09
DAPK3 Death-associated protein kinase 3
1
2
7.09
SIK1 Serine/threonine-protein kinase SIK1
1
2
7.08
MARK1 Serine/threonine-protein kinase MARK1
0
2
7.08
FYN Tyrosine-protein kinase Fyn
44
2
7.07
ACVR1B Activin receptor type-1B
3
3
7.07
TAOK3 Serine/threonine-protein kinase TAO3
3
2
7.07
CIT Citron Rho-interacting kinase
5
2
7.06
CDK7 Cyclin-dependent kinase 7
34
2
7.04
CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma
21
3
7.01
STK25 Serine/threonine-protein kinase 25
0
2
7.01
EPHB6 Ephrin type-B receptor 6
4
2
7.01
TSSK1B Testis-specific serine/threonine-protein kinase 1
0
2
7
PRKCQ Protein kinase C theta type
9
2
6.96
7.51
CSF1R Macrophage colony-stimulating factor 1 receptor
3
3
6.96
MAP4K3 Mitogen-activated protein kinase kinase kinase kinase 3
0
3
6.96
TLK1 Serine/threonine-protein kinase tousled-like 1
0
2
6.95
MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5
1
2
6.93
RPS6KB1 Ribosomal protein S6 kinase beta-1
1
2
6.93
TYK2 Non-receptor tyrosine-protein kinase TYK2
20
2
6.92
EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase
6
2
6.92
SBK3 Uncharacterized serine/threonine-protein kinase SBK3
0
2
6.92
MARK4 MAP/microtubule affinity-regulating kinase 4
1
3
6.92
SIK3 Serine/threonine-protein kinase SIK3
0
3
6.92
TGFBR1 TGF-beta receptor type-1
10
3
6.92
FLT1 Vascular endothelial growth factor receptor 1
2
2
6.89
CAMK1 Calcium/calmodulin-dependent protein kinase type 1
2
2
6.85
PRKCH Protein kinase C eta type
2
2
6.85
RPS6KA4 Ribosomal protein S6 kinase alpha-4
1
3
6.82
HIPK4 Homeodomain-interacting protein kinase 4
0
2
6.8
PRKACB cAMP-dependent protein kinase catalytic subunit beta
27
2
6.8
EPHA3 Ephrin type-A receptor 3
3
2
6.8
PRKCE Protein kinase C epsilon type
5
2
6.8
BLK Tyrosine-protein kinase Blk
2
2
6.8
YES1 Tyrosine-protein kinase Yes
17
2
6.77
MAP3K6 Mitogen-activated protein kinase kinase kinase 6
0
3
6.72
LYN Tyrosine-protein kinase Lyn
36
2
6.7
PIM1 Serine/threonine-protein kinase pim-1
3
2
6.7
BMX Cytoplasmic tyrosine-protein kinase BMX
2
2
6.7
SBK1 Serine/threonine-protein kinase SBK1
0
1
6.68
CHEK2 Serine/threonine-protein kinase Chk2
8
2
6.66
PRKACA cAMP-dependent protein kinase catalytic subunit alpha
39
1
6.66
PLK1 Serine/threonine-protein kinase PLK1
25
2
6.66
STK38 Serine/threonine-protein kinase 38
2
2
6.66
KDR Vascular endothelial growth factor receptor 2
7
2
6.64
PIK3C2G Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma
2
2
6.64
MAPKAPK2 MAP kinase-activated protein kinase 2
10
2
6.64
STK26 Serine/threonine-protein kinase 26
1
2
6.62
PRKCD Protein kinase C delta type
14
2
6.62
DMPK Myotonin-protein kinase
1
2
6.6
HIPK3 Homeodomain-interacting protein kinase 3
0
2
6.6
PIM2 Serine/threonine-protein kinase pim-2
0
2
6.59
MET Hepatocyte growth factor receptor
19
2
6.58
MYO3A Myosin-IIIa
2
2
6.58
EPHA7 Ephrin type-A receptor 7
3
2
6.58
CSK Tyrosine-protein kinase CSK
13
2
6.57
HCK Tyrosine-protein kinase HCK
9
2
6.54
RPS6KA2 Ribosomal protein S6 kinase alpha-2
7
2
6.54
TESK1 Dual specificity testis-specific protein kinase 1
1
2
6.54
PI4KB Phosphatidylinositol 4-kinase beta
1
2
6.54
RPS6KA5 Ribosomal protein S6 kinase alpha-5
5
2
6.54
ITK Tyrosine-protein kinase ITK/TSK
2
2
6.54
ERN2 Serine/threonine-protein kinase/endoribonuclease IRE2
0
1
6.54
RPS6KA1 Ribosomal protein S6 kinase alpha-1
8
3
6.51
FGFR1 Fibroblast growth factor receptor 1
22
2
6.5
MAPK9 Mitogen-activated protein kinase 9
5
3
6.48
RPS6KA6 Ribosomal protein S6 kinase alpha-6
3
3
6.48
CASK Peripheral plasma membrane protein CASK
7
1
6.48
PLK2 Serine/threonine-protein kinase PLK2
3
2
6.47
MAP3K13 Mitogen-activated protein kinase kinase kinase 13
0
2
6.46
PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
9
2
6.44
PDGFRA Platelet-derived growth factor receptor alpha
13
2
6.43
STK38L Serine/threonine-protein kinase 38-like
0
2
6.43
FES Tyrosine-protein kinase Fes/Fps
4
3
6.43
HIPK2 Homeodomain-interacting protein kinase 2
6
2
6.43
MAPK12 Mitogen-activated protein kinase 12
6
2
6.43
PRKG1 cGMP-dependent protein kinase 1
3
2
6.42
EPHA1 Ephrin type-A receptor 1
4
2
6.4
DDR2 Discoidin domain-containing receptor 2
1
2
6.39
CDK5 Cyclin-dependent kinase 5
9
3
6.38
CDK3 Cyclin-dependent kinase 3
0
3
6.38
CSNK2A2 Casein kinase II subunit alpha'
11
2
6.37
CDKL3 Cyclin-dependent kinase-like 3
0
2
6.37
LCK Proto-oncogene tyrosine-protein kinase LCK
23
2
6.37
CSNK2A1 Casein kinase II subunit alpha
11
2
6.33
CAMK1G Calcium/calmodulin-dependent protein kinase type 1G
0
1
6.31
LTK Leukocyte tyrosine kinase receptor
1
2
6.31
CDKL1 Cyclin-dependent kinase-like 1
0
1
6.3
TAOK2 Serine/threonine-protein kinase TAO2
0
1
6.29
DDR1 Epithelial discoidin domain-containing receptor 1
1
2
6.28
CDK9 Cyclin-dependent kinase 9
15
2
6.27
TGFBR2 TGF-beta receptor type-2
10
3
6.26
PRP4K Serine/threonine-protein kinase PRP4 homolog
1
2
6.24
HUNK Hormonally up-regulated neu tumor-associated kinase
0
2
6.23
HIPK1 Homeodomain-interacting protein kinase 1
3
2
6.2
PRKCA Protein kinase C alpha type
20
2
6.2
TEK Angiopoietin-1 receptor
2
2
6.19
RIPK2 Receptor-interacting serine/threonine-protein kinase 2
9
2
6.19
TYRO3 Tyrosine-protein kinase receptor TYRO3
0
2
6.19
FGFR3 Fibroblast growth factor receptor 3
16
2
6.19
SRC Proto-oncogene tyrosine-protein kinase Src
68
2
6.18
FGFR2 Fibroblast growth factor receptor 2
17
2
6.18
TXK Tyrosine-protein kinase TXK
1
2
6.17
TIE1 Tyrosine-protein kinase receptor Tie-1
0
2
6.14
CDK17 Cyclin-dependent kinase 17
0
2
6.14
CDK14 Cyclin-dependent kinase 14
0
2
6.13
FRK Tyrosine-protein kinase FRK
2
2
6.12
STK24 Serine/threonine-protein kinase 24
2
2
6.11
MYO3B Myosin-IIIb
2
2
6.11
NLK Serine/threonine-protein kinase NLK
1
2
6.1
EGFR Epidermal growth factor receptor
36
2
6.1
EPHA2 Ephrin type-A receptor 2
12
2
6.09
STK35 Serine/threonine-protein kinase 35
0
2
6.09
SRMS Tyrosine-protein kinase Srms
1
2
6.08
DLK1 Protein delta homolog 1
1
2
6.08
MAP3K12 Mitogen-activated protein kinase kinase kinase 12
0
1
6.05
PRKAG1 5'-AMP-activated protein kinase subunit gamma-1
8
1
6.05
PRKAG2 5'-AMP-activated protein kinase subunit gamma-2
10
1
6.03
MAPKAPK5 MAP kinase-activated protein kinase 5
3
2
6.02
BMPR1A Bone morphogenetic protein receptor type-1A
1
2
6.01
ABL1 Tyrosine-protein kinase ABL1
13
2
6.01
MATK Megakaryocyte-associated tyrosine-protein kinase
1
2
6
ULK1 Serine/threonine-protein kinase ULK1
5
2
6
CDC42BPB Serine/threonine-protein kinase MRCK beta
3
2
6
CDK13 Cyclin-dependent kinase 13
2
1
5.96
STK39 STE20/SPS1-related proline-alanine-rich protein kinase
0
2
5.96
MAPK7 Mitogen-activated protein kinase 7
6
2
5.96
DCLK3 Serine/threonine-protein kinase DCLK3
0
2
5.96
PTK2 Focal adhesion kinase 1
17
2
5.96
INSR Insulin receptor
6
2
5.92
EPHA6 Ephrin type-A receptor 6
3
2
5.92
TEC Tyrosine-protein kinase Tec
3
2
5.92
WEE1 Wee1-like protein kinase
7
2
5.89
RPS6KA3 Ribosomal protein S6 kinase alpha-3
7
3
5.89
GSK3B Glycogen synthase kinase-3 beta
24
1
5.89
CDK15 Cyclin-dependent kinase 15
0
2
5.86
PKN3 Serine/threonine-protein kinase N3
4
1
5.85
ERBB4 Receptor tyrosine-protein kinase erbB-4
20
2
5.82
BMPR2 Bone morphogenetic protein receptor type-2
1
3
5.8
LIMK1 LIM domain kinase 1
6
2
5.8
HTT Huntingtin
1
1
5.77
MAK Serine/threonine-protein kinase MAK
0
2
5.77
PTK6 Protein-tyrosine kinase 6
12
3
5.77
EPHA4 Ephrin type-A receptor 4
4
2
5.75
PRKCI Protein kinase C iota type
4
1
5.75
FGFR4 Fibroblast growth factor receptor 4
14
2
5.75
INSRR Insulin receptor-related protein
0
2
5.75
NIM1K Serine/threonine-protein kinase NIM1
0
2
5.75
CDK6 Cyclin-dependent kinase 6
9
1
5.68
TNNI3K Serine/threonine-protein kinase TNNI3K
0
2
5.68
AKT2 RAC-beta serine/threonine-protein kinase
32
2
5.68
STK32A Serine/threonine-protein kinase 32A
0
1
5.66
ACVRL1 Activin receptor type-1-like
1
2
5.64
PLK3 Serine/threonine-protein kinase PLK3
2
2
5.64
GSK3A Glycogen synthase kinase-3 alpha
6
2
5.6
ACVR2A Activin receptor type-2A
5
2
5.6
NEK1 Serine/threonine-protein kinase Nek1
1
2
5.6
CDC42BPG Serine/threonine-protein kinase MRCK gamma
0
2
5.58
MAP3K4 Mitogen-activated protein kinase kinase kinase 4
0
2
5.52
CAMK4 Calcium/calmodulin-dependent protein kinase type IV
6
2
5.49
NQO2 Ribosyldihydronicotinamide dehydrogenase [quinone]
1
1
5.46
MAPK13 Mitogen-activated protein kinase 13
3
2
5.42
STK36 Serine/threonine-protein kinase 36
0
2
5.42
ACVR2B Activin receptor type-2B
4
2
5.4
PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
14
1
5.4
NEK7 Serine/threonine-protein kinase Nek7
3
2
5.39
MUSK Muscle, skeletal receptor tyrosine-protein kinase
1
1
5.38
IGF1R Insulin-like growth factor 1 receptor
5
2
5.36
MAP3K1 Mitogen-activated protein kinase kinase kinase 1
5
2
5.36
AKT1 RAC-alpha serine/threonine-protein kinase
42
2
5.36
NEK6 Serine/threonine-protein kinase Nek6
3
1
5.35
DCLK2 Serine/threonine-protein kinase DCLK2
0
1
5.31
PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
60
2
5.31
NEK2 Serine/threonine-protein kinase Nek2
8
1
5.28
PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
1
1
5.28
EPHB1 Ephrin type-B receptor 1
4
2
5.27
NEK9 Serine/threonine-protein kinase Nek9
3
1
5.26
ERBB3 Receptor tyrosine-protein kinase erbB-3
15
1
5.25
NEK5 Serine/threonine-protein kinase Nek5
0
1
5.25
CRK2 Cyclin-dependent kinase 2 homolog
0
1
5.23
STK32B Serine/threonine-protein kinase 32B
0
2
5.23
EPHA5 Ephrin type-A receptor 5
3
1
5.21
AKT3 RAC-gamma serine/threonine-protein kinase
27
2
5.19
ABL2 Tyrosine-protein kinase ABL2
4
1
5.17
MAP3K20 Mitogen-activated protein kinase kinase kinase 20
0
1
5.17
RIOK2 Serine/threonine-protein kinase RIO2
1
2
5.17
PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
32
1
5.16
EPHB4 Ephrin type-B receptor 4
4
1
5.16
EPHB2 Ephrin type-B receptor 2
5
1
5.15
CSNK1A1L Casein kinase I isoform alpha-like
0
1
5.1
CDK8 Cyclin-dependent kinase 8
9
1
5.1
OXSR1 Serine/threonine-protein kinase OSR1
0
1
5.1
WEE2 Wee1-like protein kinase 2
0
1
5.1
STK32C Serine/threonine-protein kinase 32C
0
1
5.09
MST1R Macrophage-stimulating protein receptor
1
2
5.04
CDC42BPA Serine/threonine-protein kinase MRCK alpha
4
1
5.01
MAPK3 Mitogen-activated protein kinase 3
59
1
4.95
RORC Nuclear receptor ROR-gamma
3
1
4.8
KMT2A,MEN1 Menin/Histone-lysine N-methyltransferase MLL
0
1
Target pathways
779
Acetylcholine regulates insulin secretion
R-HSA-399997
PRKCA
Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-2122948
DLK1
Activated NTRK2 signals through CDK5
R-HSA-9032845
CDK5
NTRK2
Activated NTRK2 signals through FRS2 and FRS3
R-HSA-9028731
NTRK2
Activated NTRK2 signals through FYN
R-HSA-9032500
FYN
SRC
NTRK2
Activated NTRK2 signals through PI3K
R-HSA-9028335
PIK3CA
NTRK2
Activated NTRK2 signals through PLCG1
R-HSA-9026527
NTRK2
Activated NTRK2 signals through RAS
R-HSA-9026519
NTRK2
Activated NTRK3 signals through PI3K
R-HSA-9603381
PIK3CA
NTRK3
SRC
Activated NTRK3 signals through PLCG1
R-HSA-9034793
NTRK3
Activated NTRK3 signals through RAS
R-HSA-9034864
NTRK3
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-5625886
PKN1
Activated point mutants of FGFR2
R-HSA-2033519
FGFR2
activated TAK1 mediates p38 MAPK activation
R-HSA-450302
IRAK1
MAPKAPK2
MAP3K7
MAP2K6
RIPK2
MAP2K3
Activation of AKT2
R-HSA-165158
AKT2
PDPK1
Activation of AMPK downstream of NMDARs
R-HSA-9619483
PRKAG2
PRKAA1
PRKAA2
CAMKK2
PRKAG1
Activation of ATR in response to replication stress
R-HSA-176187
CHEK1
CDK2
Activation of BAD and translocation to mitochondria
R-HSA-111447
AKT1
AKT2
AKT3
Activation of BIM and translocation to mitochondria
R-HSA-111446
MAPK8
Activation of BMF and translocation to mitochondria
R-HSA-139910
MAPK8
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
R-HSA-936964
IKBKE
TBK1
Activation of NF-kappaB in B cells
R-HSA-1169091
MAP3K7
CHUK
IKBKB
Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-2980767
NEK6
PLK1
NEK9
NEK7
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-2151209
MAPK12
PRKAG2
PRKAA2
PRKAG1
Activation of RAC1
R-HSA-428540
PAK5
PAK6
PAK2
PAK3
PAK4
PAK1
Activation of RAC1 downstream of NMDARs
R-HSA-9619229
CAMK1
CAMKK2
CAMKK1
Activation of the AP-1 family of transcription factors
R-HSA-450341
MAPK3
MAPK9
MAPK8
MAPK10
Activation of the pre-replicative complex
R-HSA-68962
CDK2
ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9660821
PRKX
PRKACB
PRKACA
ADP signalling through P2Y purinoceptor 1
R-HSA-418592
SRC
Advanced glycosylation endproduct receptor signaling
R-HSA-879415
MAPK3
AKT phosphorylates targets in the cytosol
R-HSA-198323
AKT1
AKT2
AKT3
CHUK
GSK3B
GSK3A
AKT phosphorylates targets in the nucleus
R-HSA-198693
AKT1
AKT2
AKT3
AKT-mediated inactivation of FOXO1A
R-HSA-211163
AKT1
AKT2
AKT3
alectinib-resistant ALK mutants
R-HSA-9717316
ALK
ALK mutants bind TKIs
R-HSA-9700645
ALK
Alpha-protein kinase 1 signaling pathway
R-HSA-9645460
MAP3K7
AMPK inhibits chREBP transcriptional activation activity
R-HSA-163680
PRKAG2
STK11
PRKAA2
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-141444
PLK1
TAOK1
AURKB
Anchoring of the basal body to the plasma membrane
R-HSA-5620912
PLK1
NEK2
MARK4
PLK4
PRKACA
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-983695
LYN
PIK3CD
FYN
BLK
BTK
SYK
APC truncation mutants have impaired AXIN binding
R-HSA-5467337
GSK3B
APC-Cdc20 mediated degradation of Nek2A
R-HSA-179409
NEK2
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174178
PLK1
AURKA
AURKB
Apoptotic cleavage of cellular proteins
R-HSA-111465
PTK2
BMX
PRKCQ
STK24
PRKCD
ROCK1
STK26
Apoptotic execution phase
R-HSA-75153
STK24
ARMS-mediated activation
R-HSA-170984
NTRK1
ASP-3026-resistant ALK mutants
R-HSA-9717264
ALK
Assembly and cell surface presentation of NMDA receptors
R-HSA-9609736
CAMK2B
CAMK2D
CAMK2G
CAMK2A
CASK
Association of TriC/CCT with target proteins during biosynthesis
R-HSA-390471
STAT3
AURKA Activation by TPX2
R-HSA-8854518
PLK1
NEK2
AURKA
PLK4
PRKACA
AXIN missense mutants destabilize the destruction complex
R-HSA-5467340
GSK3B
B-WICH complex positively regulates rRNA expression
R-HSA-5250924
GSK3B
BDNF activates NTRK2 (TRKB) signaling
R-HSA-9024909
NTRK2
Beta-catenin phosphorylation cascade
R-HSA-196299
GSK3B
betaKlotho-mediated ligand binding
R-HSA-1307965
FGFR4
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-111453
STAT3
brigatinib-resistant ALK mutants
R-HSA-9717319
ALK
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450385
MAPKAPK2
AKT1
Ca2+ pathway
R-HSA-4086398
MAP3K7
PRKG2
PRKG1
NLK
PRKCA
CAMK2A
Calmodulin induced events
R-HSA-111933
PRKCD
PRKCA
CaMK IV-mediated phosphorylation of CREB
R-HSA-111932
CAMK4
CAMK2B
CAMKK2
CAMK2D
CAMKK1
CAMK2G
CAMK2A
Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856825
EGFR
AAK1
Carnitine shuttle
R-HSA-200425
PRKAG2
PRKAA2
Caspase activation via Dependence Receptors in the absence of ligand
R-HSA-418889
DAPK3
DAPK2
DAPK1
CD163 mediating an anti-inflammatory response
R-HSA-9662834
PLK2
CD209 (DC-SIGN) signaling
R-HSA-5621575
LYN
RPS6KA5
PRKACB
FYN
PAK2
PAK3
PAK1
PRKACA
CD22 mediated BCR regulation
R-HSA-5690714
LYN
CD28 dependent PI3K/Akt signaling
R-HSA-389357
PIK3CB
PIK3CD
PIK3CA
AKT1
AKT2
AKT3
FYN
PIK3CG
LCK
PDPK1
CD28 dependent Vav1 pathway
R-HSA-389359
FYN
PAK2
PAK3
LCK
PAK1
CDC42 GTPase cycle
R-HSA-9013148
PAK5
CDC42BPA
PAK6
CDC42BPB
PAK2
MAP3K11
PAK3
PAK4
PAK1
CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69017
CDK2
Cell surface interactions at the vascular wall
R-HSA-202733
LYN
MERTK
FYN
ceritinib-resistant ALK mutants
R-HSA-9717323
ALK
cGMP effects
R-HSA-418457
PRKG2
PRKG1
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-75035
CHEK2
CHEK1
WEE1
Circadian Clock
R-HSA-400253
SIK1
Clathrin-mediated endocytosis
R-HSA-8856828
GAK
EGFR
AAK1
CLEC7A (Dectin-1) signaling
R-HSA-5607764
PRKCD
MAP3K7
CHUK
SYK
PDPK1
SRC
IKBKB
Co-inhibition by CTLA4
R-HSA-389513
LYN
AKT1
AKT2
YES1
AKT3
FYN
LCK
SRC
Co-inhibition by PD-1
R-HSA-389948
CSK
LCK
Co-stimulation by CD28
R-HSA-389356
LYN
YES1
FYN
LCK
SRC
Co-stimulation by ICOS
R-HSA-9927354
PIK3CB
PIK3CD
PIK3CA
PIK3CG
Condensation of Prometaphase Chromosomes
R-HSA-2514853
CSNK2A1
CSNK2A2
Condensation of Prophase Chromosomes
R-HSA-2299718
PLK1
Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-2219530
PIK3CB
FGFR1
PIK3CD
PIK3CA
PDGFRB
ERBB4
FGFR2
FLT3
PDGFRA
FGFR4
NTRK3
FYN
FGFR3
EGFR
MET
PIK3CG
ERBB3
LCK
SRC
NTRK2
KIT
Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-5674400
AKT1
AKT2
AKT3
CHUK
PDPK1
GSK3B
GSK3A
Constitutive Signaling by EGFRvIII
R-HSA-5637810
PIK3CA
EGFR
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1236382
PIK3CA
EGFR
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2894862
CDK8
Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2644606
CDK8
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-6814122
CSNK2A1
CSNK2A2
CREB phosphorylation
R-HSA-199920
RPS6KA3
RPS6KA5
MAPKAPK2
RPS6KA2
RPS6KA1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
R-HSA-442742
RPS6KA3
RPS6KA2
RPS6KA1
RPS6KA6
CREB1 phosphorylation through the activation of Adenylate Cyclase
R-HSA-442720
PRKX
PRKACB
PRKACA
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
R-HSA-442729
CAMK4
CAMK2B
CAMKK2
CAMKK1
CAMK2G
crenolanib-resistant FLT3 mutants
R-HSA-9702581
FLT3
crizotinib-resistant ALK mutants
R-HSA-9717326
ALK
CRMPs in Sema3A signaling
R-HSA-399956
CDK5
FES
FYN
GSK3B
CTNNB1 S33 mutants aren't phosphorylated
R-HSA-5358747
GSK3B
CTNNB1 S37 mutants aren't phosphorylated
R-HSA-5358749
GSK3B
CTNNB1 S45 mutants aren't phosphorylated
R-HSA-5358751
GSK3B
CTNNB1 T41 mutants aren't phosphorylated
R-HSA-5358752
GSK3B
Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69273
PLK1
CDK2
WEE1
CDK7
Cyclin A:Cdk2-associated events at S phase entry
R-HSA-69656
AKT1
AKT2
AKT3
CDK2
WEE1
CDK7
Cyclin D associated events in G1
R-HSA-69231
PTK6
LYN
JAK2
ABL1
CDK2
SRC
CDK6
CDK7
CDK4
Cyclin E associated events during G1/S transition
R-HSA-69202
AKT1
AKT2
AKT3
CDK2
WEE1
CDK7
Cytoprotection by HMOX1
R-HSA-9707564
PTK6
STAT3
DAG and IP3 signaling
R-HSA-1489509
PRKCD
PRKCE
DAP12 signaling
R-HSA-2424491
PIK3CB
PIK3CA
FYN
BTK
SYK
LCK
DARPP-32 events
R-HSA-180024
CDK5
PRKACB
PRKACA
Dasatinib-resistant KIT mutants
R-HSA-9669914
KIT
DCC mediated attractive signaling
R-HSA-418885
PTK2
FYN
SRC
DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-168928
TBK1
Deactivation of the beta-catenin transactivating complex
R-HSA-3769402
AKT1
AKT2
Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607761
CHUK
Dectin-2 family
R-HSA-5621480
LYN
FYN
SYK
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
R-HSA-9661069
CDK2
CDK6
CDK4
Degradation of AXIN
R-HSA-4641257
TNKS2
Degradation of beta-catenin by the destruction complex
R-HSA-195253
GSK3B
Degradation of GLI1 by the proteasome
R-HSA-5610780
PRKACB
PRKACA
Degradation of GLI2 by the proteasome
R-HSA-5610783
PRKACB
GSK3B
PRKACA
Depolymerization of the Nuclear Lamina
R-HSA-4419969
PRKCA
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-8862803
CDK5
Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-4641262
GSK3B
Disinhibition of SNARE formation
R-HSA-114516
PRKCA
DNA Damage/Telomere Stress Induced Senescence
R-HSA-2559586
CDK2
Dopamine Neurotransmitter Release Cycle
R-HSA-212676
CASK
Downregulation of ERBB2 signaling
R-HSA-8863795
EGFR
ERBB3
ERBB4
MATK
Downregulation of ERBB2:ERBB3 signaling
R-HSA-1358803
AKT1
AKT2
AKT3
ERBB3
Downregulation of ERBB4 signaling
R-HSA-1253288
ERBB4
SRC
Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2173795
MAPK3
Downregulation of TGF-beta receptor signaling
R-HSA-2173788
TGFBR2
TGFBR1
Downstream signal transduction
R-HSA-186763
PIK3CB
PIK3CA
PDGFRB
STAT3
PDGFRA
STAT5A
SRC
Downstream signaling of activated FGFR1
R-HSA-5654687
FGFR1
Downstream TCR signaling
R-HSA-202424
PIK3CB
PRKCQ
MAP3K7
PIK3CA
RIPK2
CHUK
LCK
PDPK1
IKBKB
Drug-mediated inhibition of CDK4/CDK6 activity
R-HSA-9754119
CDK6
CDK4
Drug-mediated inhibition of MET activation
R-HSA-9734091
MET
Dual incision in TC-NER
R-HSA-6782135
CDK7
ECM proteoglycans
R-HSA-3000178
MUSK
Effects of PIP2 hydrolysis
R-HSA-114508
PRKCQ
PRKCD
PRKCE
PRKCH
EGFR downregulation
R-HSA-182971
EGFR
EGFR interacts with phospholipase C-gamma
R-HSA-212718
EGFR
EGFR Transactivation by Gastrin
R-HSA-2179392
EGFR
PRKCA
EML4 and NUDC in mitotic spindle formation
R-HSA-9648025
NEK6
PLK1
NEK9
NEK7
TAOK1
AURKB
Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-380972
PRKAG2
STK11
PRKAA1
PRKAA2
PRKAG1
eNOS activation
R-HSA-203615
AKT1
EPH-ephrin mediated repulsion of cells
R-HSA-3928665
LYN
YES1
EPHA7
EPHB1
EPHA6
EPHB6
EPHA4
EPHA5
FYN
EPHA1
EPHB4
EPHA3
SRC
EPHB2
EPHA2
EPH-Ephrin signaling
R-HSA-2682334
LYN
YES1
EPHA7
EPHB1
EPHA6
EPHB6
EPHA4
EPHA5
FYN
EPHA1
EPHB4
EPHA3
SRC
EPHB2
EPHA2
EPHA-mediated growth cone collapse
R-HSA-3928663
ROCK2
LYN
YES1
ROCK1
EPHA7
EPHA6
EPHA4
EPHA5
FYN
EPHA1
EPHA3
SRC
EPHA2
EPHB-mediated forward signaling
R-HSA-3928662
PTK2
LIMK1
ROCK2
LYN
YES1
ROCK1
EPHB1
EPHB6
FYN
EPHB4
SRC
EPHB2
PAK1
Ephrin signaling
R-HSA-3928664
EPHB1
EPHB6
FYN
PAK2
EPHB4
PAK3
SRC
EPHB2
PAK1
Epithelial-Mesenchymal Transition (EMT) during gastrulation
R-HSA-9758919
FGFR1
ER-Phagosome pathway
R-HSA-1236974
BTK
CHUK
IKBKB
ERBB2 Activates PTK6 Signaling
R-HSA-8847993
PTK6
EGFR
ERBB3
ERBB4
ERBB2 Regulates Cell Motility
R-HSA-6785631
ERBB4
EGFR
ERBB3
ERK/MAPK targets
R-HSA-198753
MAPK3
RPS6KA3
RPS6KA5
RPS6KA2
RPS6KA1
MAPK7
ERKs are inactivated
R-HSA-202670
MAPK3
MAPK7
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-HSA-9027276
LYN
PIK3CB
PIK3CD
PIK3CA
JAK2
PIK3CG
Erythropoietin activates Phospholipase C gamma (PLCG)
R-HSA-9027277
LYN
JAK2
Erythropoietin activates RAS
R-HSA-9027284
LYN
JAK2
Erythropoietin activates STAT5
R-HSA-9027283
LYN
JAK2
STAT5A
ESR-mediated signaling
R-HSA-8939211
MAPK3
Estrogen-dependent gene expression
R-HSA-9018519
ERBB4
CDK9
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
R-HSA-9634638
PTK2
MAPK3
AKT1
AKT2
EGFR
AKT3
Estrogen-stimulated signaling through PRKCZ
R-HSA-9634635
PDPK1
Evasion by RSV of host interferon responses
R-HSA-9833109
TYK2
JAK1
EIF2AK2
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
R-HSA-9630791
CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
R-HSA-9630794
CDK6
CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
R-HSA-9632697
CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
R-HSA-9632700
CDK6
CDK4
Extra-nuclear estrogen signaling
R-HSA-9009391
PTK2
PIK3CA
AKT1
EGFR
IGF1R
SRC
Factors involved in megakaryocyte development and platelet production
R-HSA-983231
CDK5
JAK2
ABL1
PRKACB
CDK2
WEE1
PRKACA
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8854050
AURKA
Fc epsilon receptor (FCERI) signaling
R-HSA-2454202
LYN
SYK
FCERI mediated Ca+2 mobilization
R-HSA-2871809
LYN
ITK
TEC
BTK
SYK
TXK
FCERI mediated MAPK activation
R-HSA-2871796
MAP2K4
MAPK3
LYN
MAP2K7
MAPK9
MAPK8
MAP3K1
PAK2
MAPK10
SYK
PAK1
FCERI mediated NF-kB activation
R-HSA-2871837
LYN
PRKCQ
MAP3K7
CHUK
PDPK1
IKBKB
FCGR activation
R-HSA-2029481
LYN
YES1
FGR
FYN
HCK
SYK
SRC
FCGR3A-mediated IL10 synthesis
R-HSA-9664323
LYN
PRKX
YES1
FGR
PRKACB
FYN
HCK
SYK
SRC
PRKACA
FCGR3A-mediated phagocytosis
R-HSA-9664422
PTK2
MAPK3
LYN
YES1
FGR
ABL1
FYN
HCK
BTK
SYK
SRC
FGFR1b ligand binding and activation
R-HSA-190370
FGFR1
FGFR1c and Klotho ligand binding and activation
R-HSA-190374
FGFR1
FGFR1c ligand binding and activation
R-HSA-190373
FGFR1
FGFR2b ligand binding and activation
R-HSA-190377
FGFR2
FGFR2c ligand binding and activation
R-HSA-190375
FGFR2
FGFR3b ligand binding and activation
R-HSA-190371
FGFR3
FGFR3c ligand binding and activation
R-HSA-190372
FGFR3
FGFR4 ligand binding and activation
R-HSA-190322
FGFR4
FGFR4 mutant receptor activation
R-HSA-1839128
FGFR4
FLT3 mutants bind TKIs
R-HSA-9702509
FLT3
FLT3 Signaling
R-HSA-9607240
PIK3CA
AKT1
AKT2
FLT3
AKT3
FLT3 signaling by CBL mutants
R-HSA-9706377
FLT3
FLT3 signaling through SRC family kinases
R-HSA-9706374
FLT3
FYN
HCK
SYK
LCK
Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167152
CDK9
CDK7
Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167200
CDK9
CDK7
Formation of Incision Complex in GG-NER
R-HSA-5696395
CDK7
Formation of paraxial mesoderm
R-HSA-9793380
FGFR1
Formation of RNA Pol II elongation complex
R-HSA-112382
CDK9
CDK7
Formation of TC-NER Pre-Incision Complex
R-HSA-6781823
CDK7
Formation of the Early Elongation Complex
R-HSA-113418
CDK7
Formation of the HIV-1 Early Elongation Complex
R-HSA-167158
CDK7
Formation of the nephric duct
R-HSA-9830364
RET
Formation of the ureteric bud
R-HSA-9830674
RET
FOXO-mediated transcription of cell death genes
R-HSA-9614657
STK11
FRS-mediated FGFR1 signaling
R-HSA-5654693
FGFR1
FRS-mediated FGFR2 signaling
R-HSA-5654700
FGFR2
FRS-mediated FGFR3 signaling
R-HSA-5654706
FGFR3
FRS-mediated FGFR4 signaling
R-HSA-5654712
FGFR4
Frs2-mediated activation
R-HSA-170968
MAPK3
MAP2K1
NTRK1
MAP2K2
G alpha (12/13) signalling events
R-HSA-416482
ROCK2
ROCK1
BTK
G alpha (i) signalling events
R-HSA-418594
SRC
G alpha (q) signalling events
R-HSA-416476
PIK3CA
BTK
G alpha (s) signalling events
R-HSA-418555
SRC
G alpha (z) signalling events
R-HSA-418597
PRKCQ
PRKCD
PRKCE
PRKCH
PRKCA
G beta:gamma signalling through BTK
R-HSA-8964315
BTK
G beta:gamma signalling through CDC42
R-HSA-8964616
PAK1
G beta:gamma signalling through PI3Kgamma
R-HSA-392451
AKT1
AKT2
AKT3
PIK3CG
PDPK1
G0 and Early G1
R-HSA-1538133
CDK2
DYRK1A
G2 Phase
R-HSA-68911
CDK2
G2/M DNA damage checkpoint
R-HSA-69473
CHEK2
CHEK1
G2/M DNA replication checkpoint
R-HSA-69478
WEE1
GAB1 signalosome
R-HSA-180292
PIK3CA
CSK
EGFR
SRC
Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6782210
CDK7
Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-881907
MAPK3
RPS6KA3
RPS6KA2
RPS6KA1
MAPK7
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
R-HSA-8950505
PAK2
Generation of second messenger molecules
R-HSA-202433
ITK
PAK2
ZAP70
PAK3
LCK
PAK1
Generic Transcription Pathway
R-HSA-212436
CDK8
gilteritinib-resistant FLT3 mutants
R-HSA-9702590
FLT3
GLI3 is processed to GLI3R by the proteasome
R-HSA-5610785
PRKACB
GSK3B
PRKACA
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-381676
PRKACB
PRKACA
Glycogen breakdown (glycogenolysis)
R-HSA-70221
PHKG2
PHKG1
Golgi Associated Vesicle Biogenesis
R-HSA-432722
GAK
Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-162658
MAPK3
PLK1
GP1b-IX-V activation signalling
R-HSA-430116
SRC
GPER1 signaling
R-HSA-9634597
PRKACB
SRC
PRKACA
GPVI-mediated activation cascade
R-HSA-114604
LYN
PIK3CB
PIK3CA
FYN
PIK3CG
SYK
LCK
PDPK1
GRB2 events in EGFR signaling
R-HSA-179812
EGFR
GRB2 events in ERBB2 signaling
R-HSA-1963640
ERBB4
EGFR
GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-354194
PTK2
SRC
GRB7 events in ERBB2 signaling
R-HSA-1306955
ERBB3
Growth hormone receptor signaling
R-HSA-982772
MAPK3
LYN
STAT3
JAK2
STAT5A
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
R-HSA-9762114
GSK3B
HCMV Early Events
R-HSA-9609690
EGFR
HDL assembly
R-HSA-8963896
PRKACB
PRKACA
HDR through Single Strand Annealing (SSA)
R-HSA-5685938
ABL1
Hedgehog 'off' state
R-HSA-5610787
PRKACB
PRKACA
Hedgehog 'on' state
R-HSA-5632684
ULK3
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
R-HSA-9856530
PIK3CB
PIK3CD
PIK3CA
AKT1
PRKACB
FYN
PKN2
PDPK1
FLT4
KDR
PRKACA
HIV elongation arrest and recovery
R-HSA-167287
CDK9
HIV Transcription Initiation
R-HSA-167161
CDK7
HSF1-dependent transactivation
R-HSA-3371571
CAMK2B
CAMK2D
CAMK2G
CAMK2A
HuR (ELAVL1) binds and stabilizes mRNA
R-HSA-450520
PRKCD
PRKCA
IFNG signaling activates MAPKs
R-HSA-9732724
MAPK3
JAK2
JAK1
IkBA variant leads to EDA-ID
R-HSA-5603029
CHUK
IKBKB
IKBKB deficiency causes SCID
R-HSA-5602636
CHUK
IKBKB
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
R-HSA-5603027
CHUK
IKBKB
IKK complex recruitment mediated by RIP1
R-HSA-937041
CHUK
IKBKB
IL-6-type cytokine receptor ligand interactions
R-HSA-6788467
JAK2
TYK2
JAK1
Imatinib-resistant KIT mutants
R-HSA-9669917
KIT
Imatinib-resistant PDGFR mutants
R-HSA-9674396
PDGFRA
Inactivation of CSF3 (G-CSF) signaling
R-HSA-9705462
LYN
STAT3
JAK2
TYK2
STAT5A
JAK1
HCK
SYK
Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-2514859
PRKCQ
GRK7
GRK4
PRKCA
GRK1
Inhibition of PKR
R-HSA-169131
EIF2AK2
Inhibition of Signaling by Overexpressed EGFR
R-HSA-5638303
EGFR
Inhibition of TSC complex formation by PKB
R-HSA-165181
AKT2
InlA-mediated entry of Listeria monocytogenes into host cells
R-HSA-8876493
SRC
InlB-mediated entry of Listeria monocytogenes into host cell
R-HSA-8875360
MET
Insulin receptor recycling
R-HSA-77387
INSR
Insulin receptor signalling cascade
R-HSA-74751
INSR
Integrin cell surface interactions
R-HSA-216083
KDR
Integrin signaling
R-HSA-354192
PTK2
AKT1
CSK
SYK
PDPK1
SRC
Interaction between PHLDA1 and AURKA
R-HSA-8854521
AURKA
Interactions of Tat with host cellular proteins
R-HSA-176034
CDK9
Interferon alpha/beta signaling
R-HSA-909733
TYK2
JAK1
EIF2AK2
Interferon gamma signaling
R-HSA-877300
MAPK3
PRKCD
JAK2
JAK1
CAMK2B
CAMK2D
CAMK2G
CAMK2A
Interleukin receptor SHC signaling
R-HSA-912526
PIK3CB
PIK3CD
PIK3CA
JAK2
JAK3
JAK1
Interleukin-1 signaling
R-HSA-9020702
MAP3K3
IRAK1
MAP3K7
MAP2K6
IRAK3
IRAK4
CHUK
RIPK2
IKBKB
Interleukin-10 signaling
R-HSA-6783783
STAT3
TYK2
JAK1
Interleukin-12 signaling
R-HSA-9020591
JAK2
TYK2
JAK1
Interleukin-15 signaling
R-HSA-8983432
STAT3
JAK3
STAT5A
JAK1
Interleukin-2 signaling
R-HSA-9020558
JAK3
STAT5A
PTK2B
JAK1
SYK
LCK
Interleukin-20 family signaling
R-HSA-8854691
STAT3
JAK2
JAK3
TYK2
STAT5A
JAK1
Interleukin-21 signaling
R-HSA-9020958
STAT3
JAK3
STAT5A
JAK1
Interleukin-23 signaling
R-HSA-9020933
STAT3
JAK2
TYK2
Interleukin-27 signaling
R-HSA-9020956
STAT3
JAK2
TYK2
JAK1
Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-512988
PIK3CB
PIK3CD
PIK3CA
JAK2
TEC
STAT5A
PRKACA
Interleukin-35 Signalling
R-HSA-8984722
STAT3
JAK2
TYK2
JAK1
Interleukin-37 signaling
R-HSA-9008059
STAT3
TBK1
Interleukin-38 signaling
R-HSA-9007892
MAPK8
Interleukin-4 and Interleukin-13 signaling
R-HSA-6785807
AKT1
STAT3
RORC
JAK2
JAK3
TYK2
JAK1
PIM1
Interleukin-6 signaling
R-HSA-1059683
STAT3
JAK2
TYK2
JAK1
Interleukin-7 signaling
R-HSA-1266695
STAT3
JAK3
STAT5A
JAK1
Interleukin-9 signaling
R-HSA-8985947
STAT3
JAK3
STAT5A
JAK1
Ion homeostasis
R-HSA-5578775
DMPK
CAMK2B
CAMK2D
CAMK2G
CAMK2A
PRKACA
Ion transport by P-type ATPases
R-HSA-936837
CAMK2B
CAMK2D
CAMK2G
CAMK2A
IRAK1 recruits IKK complex
R-HSA-937039
IRAK1
CHUK
IKBKB
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-HSA-975144
IRAK1
CHUK
IKBKB
IRAK2 mediated activation of TAK1 complex
R-HSA-937042
MAP3K7
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-HSA-975163
MAP3K7
IRAK4 deficiency (TLR2/4)
R-HSA-5603041
IRAK4
BTK
IRAK4 deficiency (TLR5)
R-HSA-5603037
IRAK4
IRE1alpha activates chaperones
R-HSA-381070
ERN1
IRF3 mediated activation of type 1 IFN
R-HSA-1606341
TBK1
IRF3-mediated induction of type I IFN
R-HSA-3270619
TBK1
IRS activation
R-HSA-74713
INSR
IRS-mediated signalling
R-HSA-112399
PIK3CB
PIK3CA
IRS-related events triggered by IGF1R
R-HSA-2428928
IGF1R
ISG15 antiviral mechanism
R-HSA-1169408
MAPK3
JAK1
EIF2AK2
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-450321
MAP2K4
IRAK1
MAP2K7
MAP3K7
MAPK9
MAPK8
RIPK2
MAPK10
KEAP1-NFE2L2 pathway
R-HSA-9755511
PRKCD
PRKCI
AKT1
AKT2
CSNK2A1
AKT3
CSNK2A2
KIT mutants bind TKIs
R-HSA-9669921
KIT
KSRP (KHSRP) binds and destabilizes mRNA
R-HSA-450604
AKT1
KW2449-resistant FLT3 mutants
R-HSA-9702569
FLT3
L1CAM interactions
R-HSA-373760
EPHB2
lestaurtinib-resistant FLT3 mutants
R-HSA-9702596
FLT3
linifanib-resistant FLT3 mutants
R-HSA-9702998
FLT3
Lipophagy
R-HSA-9613354
PRKAG2
PRKAA2
PRKAG1
Long-term potentiation
R-HSA-9620244
ERBB4
CAMK2B
CAMK2D
CAMK2G
SRC
CAMK2A
lorlatinib-resistant ALK mutants
R-HSA-9717329
ALK
Loss of Nlp from mitotic centrosomes
R-HSA-380259
PLK1
NEK2
PLK4
PRKACA
Loss of phosphorylation of MECP2 at T308
R-HSA-9022535
CAMK4
PRKACA
Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380284
PLK1
NEK2
PLK4
PRKACA
Macroautophagy
R-HSA-1632852
PRKAG2
PRKAA1
PRKAA2
ULK1
PRKAG1
Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-6791226
RIOK1
RIOK2
RIOK3
MAP2K and MAPK activation
R-HSA-5674135
MAPK3
MARK3
MAP2K1
CSK
MAP2K2
SRC
MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-5684264
MAP2K4
MAP2K1
CHUK
IKBKB
MAPK1 (ERK2) activation
R-HSA-112411
JAK2
TYK2
JAK1
MAP2K2
MAPK3 (ERK1) activation
R-HSA-110056
MAPK3
MAP2K1
JAK2
TYK2
JAK1
MAPK6/MAPK4 signaling
R-HSA-5687128
MAPKAPK5
PRKACB
PAK2
PAK3
PAK1
PRKACA
Masitinib-resistant KIT mutants
R-HSA-9669924
KIT
Maturation of hRSV A proteins
R-HSA-9828806
CSNK2A1
CSNK2A2
Maturation of nucleoprotein
R-HSA-9694631
SRPK2
GSK3B
GSK3A
SRPK1
Maturation of nucleoprotein
R-HSA-9683610
GSK3B
GSK3A
MDK and PTN in ALK signaling
R-HSA-9851151
ALK
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
R-HSA-9856532
AKT1
MECP2 regulates neuronal receptors and channels
R-HSA-9022699
MET
Meiotic recombination
R-HSA-912446
CDK2
CDK4
MET activates PI3K/AKT signaling
R-HSA-8851907
PIK3CA
MET
MET activates PTK2 signaling
R-HSA-8874081
PTK2
MET
SRC
MET activates PTPN11
R-HSA-8865999
MET
MET activates RAP1 and RAC1
R-HSA-8875555
MET
MET activates RAS signaling
R-HSA-8851805
MET
MET activates STAT3
R-HSA-8875791
STAT3
MET
MET interacts with TNS proteins
R-HSA-8875513
MET
MET Receptor Activation
R-HSA-6806942
MET
MET receptor recycling
R-HSA-8875656
MET
midostaurin-resistant FLT3 mutants
R-HSA-9702600
FLT3
Mitochondrial protein degradation
R-HSA-9837999
PRKACA
Mitochondrial unfolded protein response (UPRmt)
R-HSA-9841251
AKT1
Mitotic Metaphase/Anaphase Transition
R-HSA-68881
PLK1
Mitotic Prometaphase
R-HSA-68877
PLK1
TAOK1
AURKB
Mitotic Telophase/Cytokinesis
R-HSA-68884
PLK1
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
R-HSA-9841922
CDK5
ABL1
CDK8
Modulation of host responses by IFN-stimulated genes
R-HSA-9909505
CHUK
IKBKB
mRNA Capping
R-HSA-72086
CDK7
mRNA Splicing - Major Pathway
R-HSA-72163
PRP4K
MTOR signalling
R-HSA-165159
AKT1
mTORC1-mediated signalling
R-HSA-166208
RPS6KB1
MyD88 cascade initiated on plasma membrane
R-HSA-975871
IRAK1
IRAK4
MAP3K1
MyD88 deficiency (TLR2/4)
R-HSA-5602498
BTK
MyD88 dependent cascade initiated on endosome
R-HSA-975155
IRAK1
IRAK4
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-166058
IRAK1
IRAK3
IRAK4
MAP3K1
BTK
Myogenesis
R-HSA-525793
MAPK12
MAP2K6
ABL1
NCAM signaling for neurite out-growth
R-HSA-375165
PTK2
MAPK3
RPS6KA5
FGFR1
FYN
SRC
Nef and signal transduction
R-HSA-164944
FYN
PAK2
HCK
LCK
Nef Mediated CD4 Down-regulation
R-HSA-167590
LCK
Negative feedback regulation of MAPK pathway
R-HSA-5674499
MAPK3
MAP2K1
MAP2K2
Negative regulation of FGFR1 signaling
R-HSA-5654726
MAPK3
FGFR1
Negative regulation of FGFR2 signaling
R-HSA-5654727
MAPK3
FGFR2
Negative regulation of FGFR3 signaling
R-HSA-5654732
MAPK3
FGFR3
Negative regulation of FGFR4 signaling
R-HSA-5654733
MAPK3
FGFR4
Negative regulation of FLT3
R-HSA-9706369
ABL2
FLT3
CSK
Negative regulation of MAPK pathway
R-HSA-5675221
MAPK12
MAPK3
MARK3
Negative regulation of MET activity
R-HSA-6807004
MET
Negative regulation of NMDA receptor-mediated neuronal transmission
R-HSA-9617324
CAMK1
CAMK4
CAMK2B
CAMK2D
CAMK2G
CAMK2A
Negative regulation of NOTCH4 signaling
R-HSA-9604323
AKT1
Negative regulation of the PI3K/AKT network
R-HSA-199418
AKT1
AKT2
AKT3
Negative regulators of DDX58/IFIH1 signaling
R-HSA-936440
IKBKE
TBK1
Nephrin family interactions
R-HSA-373753
PIK3CB
PIK3CA
FYN
CASK
Netrin mediated repulsion signals
R-HSA-418886
SRC
Netrin-1 signaling
R-HSA-373752
PRKCQ
Neurexins and neuroligins
R-HSA-6794361
CASK
Neurophilin interactions with VEGF and VEGFR
R-HSA-194306
FLT1
KDR
Neutrophil degranulation
R-HSA-6798695
STK10
PRKCD
ROCK1
FGR
FRK
CDK13
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
R-HSA-933543
CHUK
IKBKB
NF-kB is activated and signals survival
R-HSA-209560
IRAK1
IKBKB
NGF-independant TRKA activation
R-HSA-187024
NTRK1
NTRK2
NGF-stimulated transcription
R-HSA-9031628
CDK5
NIK-->noncanonical NF-kB signaling
R-HSA-5676590
CHUK
Nilotinib-resistant KIT mutants
R-HSA-9669926
KIT
NOD1/2 Signaling Pathway
R-HSA-168638
IRAK1
MAPK12
MAP3K7
MAP2K6
RIPK2
CHUK
IKBKB
MAPK13
Non-integrin membrane-ECM interactions
R-HSA-3000171
DDR1
DDR2
NoRC negatively regulates rRNA expression
R-HSA-427413
CDK7
NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2122947
CDK8
NOTCH3 Activation and Transmission of Signal to the Nucleus
R-HSA-9013507
EGFR
NOTCH4 Intracellular Domain Regulates Transcription
R-HSA-9013695
FLT4
NPAS4 regulates expression of target genes
R-HSA-9768919
MAPK3
CDK5
PLK2
RET
NRAGE signals death through JNK
R-HSA-193648
MAPK8
NRIF signals cell death from the nucleus
R-HSA-205043
MAPK8
NTF3 activates NTRK2 (TRKB) signaling
R-HSA-9025046
NTRK2
NTF3 activates NTRK3 signaling
R-HSA-9034013
NTRK3
NTF4 activates NTRK2 (TRKB) signaling
R-HSA-9026357
NTRK2
NTRK2 activates RAC1
R-HSA-9032759
FYN
NTRK2
NTRK3 as a dependence receptor
R-HSA-9603505
NTRK3
Nuclear events mediated by NFE2L2
R-HSA-9759194
PRKAA2
Nuclear events stimulated by ALK signaling in cancer
R-HSA-9725371
MAPK3
STAT3
STAT5A
ZAP70
Nuclear Pore Complex (NPC) Disassembly
R-HSA-3301854
NEK6
NEK9
NEK7
Nuclear Receptor transcription pathway
R-HSA-383280
RORC
Nuclear signaling by ERBB4
R-HSA-1251985
ERBB4
STAT5A
SRC
NVP-TAE684-resistant ALK mutants
R-HSA-9717301
ALK
Oncogene Induced Senescence
R-HSA-2559585
MAPK3
CDK6
CDK4
Orc1 removal from chromatin
R-HSA-68949
CDK2
Other interleukin signaling
R-HSA-449836
TYK2
CSF1R
JAK1
Ovarian tumor domain proteases
R-HSA-5689896
RIPK2
Oxidative Stress Induced Senescence
R-HSA-2559580
MAP2K4
MAPK3
MINK1
MAP2K7
MAPKAPK2
MAP2K6
MAPKAPK5
MAPK9
MAPK8
MAP2K3
MAPK10
TNIK
MAP3K5
MAP4K4
CDK6
CDK4
p130Cas linkage to MAPK signaling for integrins
R-HSA-372708
PTK2
SRC
p38MAPK events
R-HSA-171007
MAPK12
MAPKAPK2
SRC
MAPK13
p53-Dependent G1 DNA Damage Response
R-HSA-69563
CDK2
p75NTR recruits signalling complexes
R-HSA-209543
IRAK1
PRKCI
RIPK2
IKBKB
Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-6802955
MAPK3
MARK3
MAP2K1
JAK2
CSK
CAMK2B
MAP2K2
MAP3K11
CAMK2D
CAMK2G
SRC
CAMK2A
Pausing and recovery of HIV elongation
R-HSA-167290
CDK9
Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167238
CDK9
PDE3B signalling
R-HSA-165160
AKT2
PDGFR mutants bind TKIs
R-HSA-9674428
PDGFRA
PECAM1 interactions
R-HSA-210990
LYN
YES1
FYN
LCK
SRC
pexidartinib-resistant FLT3 mutants
R-HSA-9702605
FLT3
Phase 0 - rapid depolarisation
R-HSA-5576892
CAMK2B
CAMK2D
CAMK2G
CAMK2A
Phase I - Functionalization of compounds
R-HSA-211945
NQO2
Phospholipase C-mediated cascade: FGFR1
R-HSA-5654219
FGFR1
Phospholipase C-mediated cascade; FGFR2
R-HSA-5654221
FGFR2
Phospholipase C-mediated cascade; FGFR3
R-HSA-5654227
FGFR3
Phospholipase C-mediated cascade; FGFR4
R-HSA-5654228
FGFR4
Phosphorylation of CD3 and TCR zeta chains
R-HSA-202427
CSK
LCK
Phosphorylation of Emi1
R-HSA-176417
PLK1
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-HSA-69200
CDK2
Phosphorylation of the APC/C
R-HSA-176412
PLK1
Physiological factors
R-HSA-5578768
HIPK1
HIPK2
PI-3K cascade:FGFR1
R-HSA-5654689
FGFR1
PIK3CA
PI-3K cascade:FGFR2
R-HSA-5654695
PIK3CA
FGFR2
PI-3K cascade:FGFR3
R-HSA-5654710
PIK3CA
FGFR3
PI-3K cascade:FGFR4
R-HSA-5654720
PIK3CA
FGFR4
PI3K Cascade
R-HSA-109704
PIK3CB
FGFR1
PIK3CA
FGFR2
FLT3
FGFR4
FGFR3
PI3K events in ERBB2 signaling
R-HSA-1963642
PIK3CA
ERBB4
EGFR
ERBB3
PI3K events in ERBB4 signaling
R-HSA-1250342
PIK3CA
ERBB4
PI3K/AKT activation
R-HSA-198203
PIK3CB
PIK3CA
NTRK1
PI5P Regulates TP53 Acetylation
R-HSA-6811555
MAP2K6
PIP4K2B
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-6811558
IRAK1
MAPK3
PIK3CB
FGFR1
PIK3CD
PIK3CA
AKT1
PDGFRB
INSR
ERBB4
FGFR2
FLT3
IRAK4
PDGFRA
FGFR4
NTRK3
FYN
FGFR3
EGFR
MET
PIK3CG
ERBB3
PIP4K2B
PIP5K1A
LCK
SRC
NTRK2
KIT
PINK1-PRKN Mediated Mitophagy
R-HSA-5205685
TBK1
PIP3 activates AKT signaling
R-HSA-1257604
IRAK1
PIK3CB
FGFR1
PIK3CD
PIK3CA
AKT1
PDGFRB
AKT2
ERBB4
FGFR2
FLT3
IRAK4
PDGFRA
FGFR4
NTRK3
AKT3
FYN
FGFR3
EGFR
MET
PIK3CG
ERBB3
LCK
PDPK1
SRC
NTRK2
KIT
PKA activation
R-HSA-163615
PRKACB
PRKACA
PKA activation in glucagon signalling
R-HSA-164378
PRKACB
PRKACA
PKA-mediated phosphorylation of CREB
R-HSA-111931
PRKX
PRKACB
PRKACA
PKA-mediated phosphorylation of key metabolic factors
R-HSA-163358
PRKACB
PRKACA
PKR-mediated signaling
R-HSA-9833482
MAP2K6
STAT3
CHUK
IKBKB
EIF2AK2
Platelet Adhesion to exposed collagen
R-HSA-75892
LYN
FYN
Platelet sensitization by LDL
R-HSA-432142
FGR
PLC-gamma1 signalling
R-HSA-167021
NTRK1
PLCG1 events in ERBB2 signaling
R-HSA-1251932
EGFR
Polo-like kinase mediated events
R-HSA-156711
PLK1
WEE1
ponatinib-resistant FLT3 mutants
R-HSA-9702614
FLT3
Potential therapeutics for SARS
R-HSA-9679191
ROCK2
ROCK1
JAK2
JAK3
TYK2
JAK1
BTK
SYK
TBK1
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-2892247
STAT3
EPHA1
PPARA activates gene expression
R-HSA-1989781
CDK8
Pre-NOTCH Transcription and Translation
R-HSA-1912408
PRKCI
Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-5693616
CHEK1
Processing of DNA double-strand break ends
R-HSA-5693607
CHEK1
CDK2
Prolactin receptor signaling
R-HSA-1170546
JAK2
STAT5A
PTK6 Activates STAT3
R-HSA-8849474
PTK6
STAT3
PTK6 Down-Regulation
R-HSA-8849472
PTK6
SRMS
PTK6 Expression
R-HSA-8849473
PTK6
PTK6 promotes HIF1A stabilization
R-HSA-8857538
PTK6
EGFR
LRRK2
PTK6 Regulates Cell Cycle
R-HSA-8849470
PTK6
CDK2
CDK4
PTK6 Regulates Proteins Involved in RNA Processing
R-HSA-8849468
PTK6
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-8849471
PTK6
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-HSA-8849469
PTK6
AKT1
quizartinib-resistant FLT3 mutants
R-HSA-9702620
FLT3
RAB GEFs exchange GTP for GDP on RABs
R-HSA-8876198
AKT1
AKT2
ULK1
AKT3
RAC1 GTPase cycle
R-HSA-9013149
ABL2
PAK5
TAOK3
PIK3CA
PAK6
CDC42BPA
PAK2
PKN2
PAK3
PKN1
CIT
PAK4
PAK1
EPHA2
RAC2 GTPase cycle
R-HSA-9013404
TAOK3
PIK3CA
PAK2
PAK4
PAK1
EPHA2
RAC3 GTPase cycle
R-HSA-9013423
ABL2
TAOK3
PAK2
PAK4
PAK1
EPHA2
RAF activation
R-HSA-5673000
MARK3
MAP2K1
JAK2
CAMK2B
MAP2K2
MAP3K11
CAMK2D
CAMK2G
SRC
CAMK2A
RAF-independent MAPK1/3 activation
R-HSA-112409
MAPK3
RAF/MAP kinase cascade
R-HSA-5673001
PTK2
MAPK3
PIK3CB
FGFR1
PIK3CA
PDGFRB
ERBB4
FGFR2
FLT3
PDGFRA
JAK2
FGFR4
JAK3
FYN
FGFR3
EGFR
MET
ERBB3
JAK1
CAMK2B
CAMK2D
TEK
RET
CAMK2G
CAMK2A
KIT
Rap1 signalling
R-HSA-392517
PRKACB
PRKG1
PRKACA
Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-442982
CAMK2B
CAMK2D
CAMK2G
CAMK2A
RAS processing
R-HSA-9648002
PRKCQ
PRKG2
Receptor Mediated Mitophagy
R-HSA-8934903
ULK1
CSNK2A1
SRC
CSNK2A2
Receptor-type tyrosine-protein phosphatases
R-HSA-388844
NTRK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693565
CHEK2
ABL1
MAPK8
Recruitment of mitotic centrosome proteins and complexes
R-HSA-380270
PLK1
NEK2
PLK4
PRKACA
Recruitment of NuMA to mitotic centrosomes
R-HSA-380320
PLK1
NEK2
PLK4
PRKACA
Recycling pathway of L1
R-HSA-437239
RPS6KA3
RPS6KA5
RPS6KA2
RPS6KA1
RPS6KA6
RPS6KA4
SRC
Reelin signalling pathway
R-HSA-8866376
FYN
Regorafenib-resistant KIT mutants
R-HSA-9669929
KIT
Regorafenib-resistant PDGFR mutants
R-HSA-9674403
PDGFRA
Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029482
PTK2
LIMK1
MAPK3
ABL1
BTK
SYK
PAK1
Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-211733
PAK2
Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176408
CDK2
Regulation of commissural axon pathfinding by SLIT and ROBO
R-HSA-428542
SRC
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-HSA-446388
TESK1
Regulation of gap junction activity
R-HSA-191650
SRC
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
R-HSA-9634600
PRKACB
PRKACA
Regulation of HSF1-mediated heat shock response
R-HSA-3371453
MAPK3
MAPKAPK2
GSK3B
Regulation of IFNA/IFNB signaling
R-HSA-912694
TYK2
JAK1
Regulation of IFNG signaling
R-HSA-877312
JAK2
JAK1
Regulation of innate immune responses to cytosolic DNA
R-HSA-3134975
TBK1
Regulation of insulin secretion
R-HSA-422356
PRKACB
PRKACA
Regulation of KIT signaling
R-HSA-1433559
LYN
YES1
FYN
LCK
SRC
PRKCA
KIT
Regulation of localization of FOXO transcription factors
R-HSA-9614399
AKT1
AKT2
AKT3
Regulation of MECP2 expression and activity
R-HSA-9022692
CAMK4
CAMK2B
CAMK2D
CAMK2G
HIPK2
AURKB
CAMK2A
HTT
PRKACA
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
R-HSA-9825892
PLK1
MET
CDK2
Regulation of MITF-M-dependent genes involved in pigmentation
R-HSA-9824585
AKT2
Regulation of NF-kappa B signaling
R-HSA-9758274
CHUK
IKBKB
Regulation of PAK-2p34 activity by PS-GAP/RHG10
R-HSA-211728
PAK2
Regulation of PLK1 Activity at G2/M Transition
R-HSA-2565942
PLK1
NEK2
AURKA
PLK4
PRKACA
Regulation of PTEN gene transcription
R-HSA-8943724
MAPK3
Regulation of PTEN stability and activity
R-HSA-8948751
AKT1
AKT2
TNKS2
FRK
CSNK2A1
AKT3
CSNK2A2
Regulation of pyruvate metabolism
R-HSA-9861718
NEK1
Regulation of RUNX1 Expression and Activity
R-HSA-8934593
SRC
CDK6
Regulation of RUNX2 expression and activity
R-HSA-8939902
GSK3B
Regulation of RUNX3 expression and activity
R-HSA-8941858
SRC
Regulation of signaling by CBL
R-HSA-912631
LYN
PIK3CB
PIK3CD
PIK3CA
YES1
FYN
HCK
SYK
Regulation of signaling by NODAL
R-HSA-1433617
ACVR2B
ACVR2A
ACVR1B
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
R-HSA-9824878
IKBKE
TBK1
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
R-HSA-9828211
IKBKE
TBK1
Regulation of the apoptosome activity
R-HSA-9627069
MAPK3
Regulation of TNFR1 signaling
R-HSA-5357905
MAPKAPK2
ULK1
IKBKE
TBK1
CHUK
IKBKB
Regulation of TP53 Activity through Acetylation
R-HSA-6804758
AKT1
AKT2
AKT3
Regulation of TP53 Activity through Association with Co-factors
R-HSA-6804759
AKT1
AKT2
AKT3
Regulation of TP53 Activity through Methylation
R-HSA-6804760
CHEK2
Regulation of TP53 Activity through Phosphorylation
R-HSA-6804756
PRKAG2
STK11
CHEK2
CHEK1
PRKAA1
CDK5
MAPKAPK5
PLK3
AURKA
HIPK1
DYRK2
PRKAA2
CSNK2A1
CDK2
NUAK1
HIPK2
AURKB
CSNK2A2
PRKAG1
Regulation of TP53 Degradation
R-HSA-6804757
CHEK2
AKT1
AKT2
AKT3
CDK2
PDPK1
Replacement of protamines by nucleosomes in the male pronucleus
R-HSA-9821993
SRPK1
Resolution of Sister Chromatid Cohesion
R-HSA-2500257
PLK1
TAOK1
AURKB
Respiratory syncytial virus (RSV) attachment and entry
R-HSA-9820960
EGFR
IGF1R
Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-9633012
EIF2AK4
Response to elevated platelet cytosolic Ca2+
R-HSA-76005
PRKCA
RET signaling
R-HSA-8853659
PIK3CB
PIK3CD
PIK3CA
PRKACB
MAPK7
RET
SRC
PRKCA
PRKACA
Retrograde neurotrophin signalling
R-HSA-177504
NTRK1
RHO GTPases activate CIT
R-HSA-5625900
CIT
RHO GTPases Activate Formins
R-HSA-5663220
PLK1
TAOK1
AURKB
SRC
RHO GTPases Activate NADPH Oxidases
R-HSA-5668599
MAPK3
PRKCD
PRKCA
RHO GTPases activate PAKs
R-HSA-5627123
LIMK1
PAK2
MYLK
PAK3
PAK1
RHO GTPases activate PKNs
R-HSA-5625740
PKN2
PKN3
PDPK1
PKN1
PAK1
RHO GTPases Activate ROCKs
R-HSA-5627117
LIMK1
ROCK2
ROCK1
PAK1
RHO GTPases Activate WASPs and WAVEs
R-HSA-5663213
PTK2
MAPK3
ABL1
BTK
RHOA GTPase cycle
R-HSA-8980692
ROCK2
STK10
ROCK1
PKN2
PKN3
SLK
PKN1
CIT
RHOB GTPase cycle
R-HSA-9013026
ROCK2
STK10
ROCK1
PKN2
PKN3
SLK
PKN1
CIT
RHOBTB1 GTPase cycle
R-HSA-9013422
ROCK2
ROCK1
STK38
RHOBTB2 GTPase cycle
R-HSA-9013418
STK38
RHOC GTPase cycle
R-HSA-9013106
ROCK2
STK10
ROCK1
PKN2
PKN3
SLK
PKN1
CIT
RHOD GTPase cycle
R-HSA-9013405
PAK5
PAK6
RHOG GTPase cycle
R-HSA-9013408
PAK2
MAP3K11
PAK4
EPHA2
RHOH GTPase cycle
R-HSA-9013407
ROCK2
PAK5
ROCK1
PAK6
CSK
PAK2
ZAP70
LCK
PAK4
PAK1
RHOJ GTPase cycle
R-HSA-9013409
CDC42BPB
CDC42BPA
PAK2
PAK3
PAK4
PAK1
RHOQ GTPase cycle
R-HSA-9013406
CDC42BPB
CDC42BPA
PAK2
PAK4
PAK1
RHOU GTPase cycle
R-HSA-9013420
PAK2
PTK2B
PAK3
SRC
PAK4
PAK1
EPHA2
RHOV GTPase cycle
R-HSA-9013424
PAK6
PAK2
MAP3K11
PAK4
PAK1
EPHA2
RIP-mediated NFkB activation via ZBP1
R-HSA-1810476
CHUK
IKBKB
RMTs methylate histone arginines
R-HSA-3214858
JAK2
CDK4
RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-77075
CDK7
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-167160
CDK7
RNA Polymerase I Promoter Escape
R-HSA-73772
CDK7
RNA Polymerase I Promoter Opening
R-HSA-73728
MAPK3
RNA Polymerase I Transcription Initiation
R-HSA-73762
CDK7
RNA Polymerase I Transcription Termination
R-HSA-73863
CDK7
RNA Polymerase II HIV Promoter Escape
R-HSA-167162
CDK7
RNA Polymerase II Pre-transcription Events
R-HSA-674695
CDK9
CDK7
RNA Polymerase II Promoter Escape
R-HSA-73776
CDK7
RNA polymerase II transcribes snRNA genes
R-HSA-6807505
CDK9
CDK7
RNA Polymerase II Transcription Elongation
R-HSA-75955
CDK9
CDK7
RNA Polymerase II Transcription Initiation
R-HSA-75953
CDK7
RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-76042
CDK7
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-73779
CDK7
RND1 GTPase cycle
R-HSA-9696273
EPHA2
RND2 GTPase cycle
R-HSA-9696270
EPHA2
RND3 GTPase cycle
R-HSA-9696264
ROCK1
EPHA2
ROBO receptors bind AKAP5
R-HSA-9010642
PRKACB
PRKCA
PRKACA
Role of ABL in ROBO-SLIT signaling
R-HSA-428890
ABL2
ABL1
Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2730905
LYN
PIK3CB
PIK3CA
FYN
SYK
PDPK1
Role of phospholipids in phagocytosis
R-HSA-2029485
PIK3CB
PRKCD
PIK3CA
PRKCE
SYK
RSK activation
R-HSA-444257
MAPK3
RPS6KA3
RPS6KA2
RPS6KA1
RPS6KA6
PDPK1
RSV-host interactions
R-HSA-9833110
CDK8
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8939243
CSNK2A1
HIPK2
CSNK2A2
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8936459
PRKCQ
RUNX1 regulates transcription of genes involved in BCR signaling
R-HSA-8939245
BLK
RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939236
ABL1
CDK7
RUNX2 regulates genes involved in cell migration
R-HSA-8941332
AKT1
AKT2
AKT3
RUNX2 regulates osteoblast differentiation
R-HSA-8940973
MAPK3
YES1
ABL1
SRC
RUNX3 Regulates Immune Response and Cell Migration
R-HSA-8949275
RORC
SARS-CoV-1 activates/modulates innate immune responses
R-HSA-9692916
IKBKE
TBK1
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
R-HSA-9735871
PDPK1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
R-HSA-9705671
IRAK1
MAP3K7
TYK2
JAK1
IKBKE
CHUK
RIPK2
IKBKB
TBK1
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
R-HSA-9755779
AKT1
AKT2
AKT3
PDPK1
SCF(Skp2)-mediated degradation of p27/p21
R-HSA-187577
PTK6
CDK2
CDK4
Sema3A PAK dependent Axon repulsion
R-HSA-399954
LIMK1
FES
FYN
PAK2
PAK3
PAK1
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399955
FES
FYN
Sema4D induced cell migration and growth-cone collapse
R-HSA-416572
LIMK1
ROCK2
ROCK1
Sema4D mediated inhibition of cell attachment and migration
R-HSA-416550
MET
semaxanib-resistant FLT3 mutants
R-HSA-9702577
FLT3
Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559582
MAPK3
RPS6KA3
STAT3
RPS6KA2
RPS6KA1
CDK2
MAPK7
CDK6
CDK4
Sensory processing of sound by inner hair cells of the cochlea
R-HSA-9662360
MYO3B
CASK
MYO3A
Sensory processing of sound by outer hair cells of the cochlea
R-HSA-9662361
MYO3B
CASK
MYO3A
Separation of Sister Chromatids
R-HSA-2467813
PLK1
TAOK1
AURKB
SHC-mediated cascade:FGFR1
R-HSA-5654688
FGFR1
SHC-mediated cascade:FGFR2
R-HSA-5654699
FGFR2
SHC-mediated cascade:FGFR3
R-HSA-5654704
FGFR3
SHC-mediated cascade:FGFR4
R-HSA-5654719
FGFR4
SHC-related events triggered by IGF1R
R-HSA-2428933
IGF1R
SHC1 events in EGFR signaling
R-HSA-180336
EGFR
SHC1 events in ERBB2 signaling
R-HSA-1250196
PRKCD
PRKCE
ERBB4
EGFR
ERBB3
PRKCA
SHC1 events in ERBB4 signaling
R-HSA-1250347
ERBB4
Signal attenuation
R-HSA-74749
MAPK3
INSR
Signal regulatory protein family interactions
R-HSA-391160
PTK2
PTK2B
SRC
Signal transduction by L1
R-HSA-445144
MAPK3
FGFR1
MAP2K1
EGFR
MAP2K2
CSNK2A1
CSNK2A2
PAK1
Signaling by activated point mutants of FGFR1
R-HSA-1839122
FGFR1
Signaling by activated point mutants of FGFR3
R-HSA-1839130
FGFR3
Signaling by Activin
R-HSA-1502540
MAPK3
ACVR2B
ACVR2A
ACVR1B
Signaling by ALK
R-HSA-201556
ALK
PIK3CB
PIK3CA
STAT3
JAK3
SRC
Signaling by ALK fusions and activated point mutants
R-HSA-9725370
ALK
PIK3CB
PIK3CA
STAT3
MAPK9
MAPK8
TYK2
Signaling by BMP
R-HSA-201451
BMPR2
BMPR1A
BMPR1B
ACVR2B
ACVR2A
ACVRL1
Signaling by BRAF and RAF1 fusions
R-HSA-6802952
MAPK3
MARK3
MAP2K1
JAK2
CSK
CAMK2B
MAP2K2
CAMK2D
CAMK2G
SRC
CAMK2A
Signaling by CSF1 (M-CSF) in myeloid cells
R-HSA-9680350
LYN
PIK3CB
PIK3CD
PIK3CA
STAT3
YES1
FYN
CSF1R
HCK
SRC
Signaling by CSF3 (G-CSF)
R-HSA-9674555
LYN
STAT3
JAK2
TYK2
STAT5A
JAK1
HCK
SYK
Signaling by cytosolic FGFR1 fusion mutants
R-HSA-1839117
PIK3CA
STAT3
STAT5A
Signaling by EGFR
R-HSA-177929
EGFR
SRC
Signaling by ERBB2
R-HSA-1227986
ERBB4
YES1
FYN
EGFR
ERBB3
SRC
Signaling by ERBB2 ECD mutants
R-HSA-9665348
PIK3CA
EGFR
Signaling by ERBB2 KD Mutants
R-HSA-9664565
PIK3CA
EGFR
ERBB3
ERBB4
Signaling by ERBB2 TMD/JMD mutants
R-HSA-9665686
EGFR
ERBB3
ERBB4
Signaling by ERBB4
R-HSA-1236394
ERBB4
EGFR
ERBB3
Signaling by Erythropoietin
R-HSA-9006335
LYN
JAK2
Signaling by extracellular domain mutants of KIT
R-HSA-9680187
KIT
Signaling by FGFR1 amplification mutants
R-HSA-1839120
FGFR1
Signaling by FGFR1 in disease
R-HSA-5655302
FGFR1
PIK3CA
Signaling by FGFR2 amplification mutants
R-HSA-2023837
FGFR2
Signaling by FGFR2 fusions
R-HSA-8853333
FGFR2
Signaling by FGFR2 IIIa TM
R-HSA-8851708
FGFR2
Signaling by FGFR2 in disease
R-HSA-5655253
PIK3CA
FGFR2
Signaling by FGFR3 fusions in cancer
R-HSA-8853334
FGFR3
Signaling by FGFR3 in disease
R-HSA-5655332
PIK3CA
FGFR3
Signaling by FGFR4 in disease
R-HSA-5655291
PIK3CA
FGFR4
Signaling by FLT3 fusion proteins
R-HSA-9703465
PIK3CA
STAT5A
PIM1
Signaling by FLT3 ITD and TKD mutants
R-HSA-9703648
PIK3CA
FLT3
Signaling by GSK3beta mutants
R-HSA-5339716
GSK3B
Signaling by high-kinase activity BRAF mutants
R-HSA-6802948
MAPK3
MARK3
MAP2K1
CSK
MAP2K2
SRC
Signaling by Hippo
R-HSA-2028269
LATS2
STK3
LATS1
STK4
Signaling by Insulin receptor
R-HSA-74752
INSR
Signaling by juxtamembrane domain KIT mutants
R-HSA-9669935
KIT
Signaling by kinase domain mutants of KIT
R-HSA-9669933
KIT
Signaling by Leptin
R-HSA-2586552
STAT3
JAK2
STAT5A
Signaling by LTK
R-HSA-9842663
LTK
TNK2
PIK3CB
PIK3CA
Signaling by LTK in cancer
R-HSA-9842640
MAPK3
PIK3CB
PIK3CA
Signaling by MAP2K mutants
R-HSA-9652169
MAPK3
MAP2K1
MAP2K2
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
R-HSA-9673768
KDR
Signaling by moderate kinase activity BRAF mutants
R-HSA-6802946
MAPK3
MARK3
MAP2K1
JAK2
CSK
CAMK2B
MAP2K2
MAP3K11
CAMK2D
CAMK2G
SRC
CAMK2A
Signaling by MST1
R-HSA-8852405
MST1R
Signaling by NODAL
R-HSA-1181150
MAPK3
ACVR2B
ACVR2A
ACVR1B
Signaling by NTRK3 (TRKC)
R-HSA-9034015
NTRK3
Signaling by PDGF
R-HSA-186797
PDGFRB
PDGFRA
Signaling by PDGFRA extracellular domain mutants
R-HSA-9673770
PIK3CB
PIK3CA
STAT3
PDGFRA
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
R-HSA-9673767
PIK3CB
PIK3CA
STAT3
PDGFRA
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
R-HSA-9670439
LYN
PIK3CA
STAT3
YES1
JAK2
FYN
STAT5A
LCK
SRC
KIT
Signaling by plasma membrane FGFR1 fusions
R-HSA-8853336
FGFR1
Signaling by RAF1 mutants
R-HSA-9656223
MAPK3
MARK3
MAP2K1
JAK2
CSK
CAMK2B
MAP2K2
CAMK2D
CAMK2G
SRC
CAMK2A
Signaling by SCF-KIT
R-HSA-1433557
LYN
CHEK1
PIK3CA
STAT3
YES1
FES
JAK2
TEC
FYN
STAT5A
FER
LCK
SRC
PRKCA
KIT
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-2404192
IGF1R
Signaling downstream of RAS mutants
R-HSA-9649948
MAPK3
MARK3
MAP2K1
JAK2
CSK
CAMK2B
MAP2K2
MAP3K11
CAMK2D
CAMK2G
SRC
CAMK2A
Signalling to ERK5
R-HSA-198765
MAP2K5
MAPK7
Signalling to p38 via RIT and RIN
R-HSA-187706
NTRK1
Signalling to RAS
R-HSA-167044
NTRK1
Signalling to STAT3
R-HSA-198745
STAT3
NTRK1
SLC15A4:TASL-dependent IRF5 activation
R-HSA-9860276
CHUK
IKBKB
SMAD2/3 Phosphorylation Motif Mutants in Cancer
R-HSA-3304356
TGFBR2
TGFBR1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-2173796
MAPK3
CDK9
CDK8
Smooth Muscle Contraction
R-HSA-445355
PAK2
MYLK
PAK1
Somitogenesis
R-HSA-9824272
EPHA4
sorafenib-resistant FLT3 mutants
R-HSA-9702624
FLT3
Sorafenib-resistant KIT mutants
R-HSA-9669936
KIT
Sorafenib-resistant PDGFR mutants
R-HSA-9674404
PDGFRA
Sphingolipid de novo biosynthesis
R-HSA-1660661
PRKD3
PRKD2
PRKD1
Spry regulation of FGF signaling
R-HSA-1295596
MAPK3
MKNK1
SRC
Stabilization of p53
R-HSA-69541
CHEK2
STAT3 nuclear events downstream of ALK signaling
R-HSA-9701898
STAT3
STAT5 Activation
R-HSA-9645135
FLT3
STAT5A
STAT5 activation downstream of FLT3 ITD mutants
R-HSA-9702518
FLT3
STAT5A
PIM1
STAT6-mediated induction of chemokines
R-HSA-3249367
TBK1
Stimulation of the cell death response by PAK-2p34
R-HSA-211736
PAK2
Stimuli-sensing channels
R-HSA-2672351
SGK3
SUMOylation of DNA replication proteins
R-HSA-4615885
AURKA
AURKB
SUMOylation of immune response proteins
R-HSA-4755510
IKBKE
EIF2AK2
SUMOylation of transcription cofactors
R-HSA-3899300
HIPK2
sunitinib-resistant FLT3 mutants
R-HSA-9702632
FLT3
Sunitinib-resistant KIT mutants
R-HSA-9669934
KIT
Sunitinib-resistant PDGFR mutants
R-HSA-9674401
PDGFRA
Suppression of apoptosis
R-HSA-9635465
MAPK3
GSK3A
Syndecan interactions
R-HSA-3000170
PRKCA
CASK
Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-2142691
MAPKAPK2
Synthesis of PC
R-HSA-1483191
CSNK2A1
CSNK2A2
Synthesis of PIPs at the Golgi membrane
R-HSA-1660514
PIK3C2G
PI4KB
Synthesis of PIPs at the plasma membrane
R-HSA-1660499
BMX
PIK3CB
PIK3CD
PIK3CA
PIK3C2G
PIK3CG
PIP4K2B
PIK3C2B
PIP5K1A
Synthesis of PIPs in the nucleus
R-HSA-8847453
PIP4K2B
t(4;14) translocations of FGFR3
R-HSA-2033515
FGFR3
TAK1-dependent IKK and NF-kappa-B activation
R-HSA-445989
IRAK1
MAP3K7
RIPK2
CHUK
IKBKB
tamatinib-resistant FLT3 mutants
R-HSA-9703009
FLT3
tandutinib-resistant FLT3 mutants
R-HSA-9702636
FLT3
Tat-mediated elongation of the HIV-1 transcript
R-HSA-167246
CDK9
CDK7
Tat-mediated HIV elongation arrest and recovery
R-HSA-167243
CDK9
TBC/RABGAPs
R-HSA-8854214
ULK1
TCF dependent signaling in response to WNT
R-HSA-201681
TNKS2
Telomere Extension By Telomerase
R-HSA-171319
CDK2
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-HSA-1474151
AKT1
PRKG2
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-HSA-8866910
EGFR
KIT
TGF-beta receptor signaling activates SMADs
R-HSA-2173789
TGFBR2
TGFBR1
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-2173791
TGFBR2
TGFBR1
TGFBR1 KD Mutants in Cancer
R-HSA-3656532
TGFBR2
TGFBR1
TGFBR1 LBD Mutants in Cancer
R-HSA-3656535
TGFBR2
TGFBR1
TGFBR2 Kinase Domain Mutants in Cancer
R-HSA-3645790
TGFBR2
TGFBR1
TGFBR2 MSI Frameshift Mutants in Cancer
R-HSA-3642279
TGFBR2
TGFBR3 regulates activin signaling
R-HSA-9839406
ACVR2A
TGFBR3 regulates TGF-beta signaling
R-HSA-9839389
TGFBR2
TGFBR1
The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8852276
PLK1
Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-456926
MAPK3
SRC
TICAM1, RIP1-mediated IKK complex recruitment
R-HSA-168927
CHUK
IKBKB
TICAM1,TRAF6-dependent induction of TAK1 complex
R-HSA-9014325
MAP3K7
TICAM1-dependent activation of IRF3/IRF7
R-HSA-9013973
IKBKE
TBK1
Tie2 Signaling
R-HSA-210993
PIK3CB
PIK3CA
TEK
Tight junction interactions
R-HSA-420029
PRKCI
TNFR1-induced NF-kappa-B signaling pathway
R-HSA-5357956
MAP3K7
CHUK
IKBKB
TNFR1-induced proapoptotic signaling
R-HSA-5357786
IKBKE
TBK1
TP53 Regulates Metabolic Genes
R-HSA-5628897
PRKAG2
PRKAA1
AKT1
AKT2
AKT3
PRKAA2
PRKAG1
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
R-HSA-6804115
PLK3
PLK2
TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6796648
CHEK1
CDK9
CDK13
CDK7
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-6804116
CDK2
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-6804114
AURKA
TRAF3-dependent IRF activation pathway
R-HSA-918233
IKBKE
TBK1
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975138
IRAK1
IRAK4
MAP3K1
TRAF6 mediated IRF7 activation
R-HSA-933541
IKBKE
TBK1
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975110
IRAK1
IRAK4
TRAF6 mediated NF-kB activation
R-HSA-933542
MAP3K1
CHUK
IKBKB
TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-HSA-937072
MAP3K7
Trafficking of AMPA receptors
R-HSA-399719
CAMK2B
CAMK2D
CAMK2G
CAMK2A
Trafficking of GluR2-containing AMPA receptors
R-HSA-416993
PRKCA
Transcription of the HIV genome
R-HSA-167172
CDK7
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6781827
CDK7
Transcriptional activation of mitochondrial biogenesis
R-HSA-2151201
CAMK4
Transcriptional and post-translational regulation of MITF-M expression and activity
R-HSA-9856649
MAPK3
MARK3
RPS6KA1
AKT3
GSK3B
KIT
Transcriptional Regulation by E2F6
R-HSA-8953750
CHEK1
Transcriptional Regulation by MECP2
R-HSA-8986944
IRAK1
Transcriptional regulation by RUNX2
R-HSA-8878166
CDK4
Transcriptional Regulation by VENTX
R-HSA-8853884
CSF1R
Transcriptional regulation of granulopoiesis
R-HSA-9616222
STAT3
CDK2
CDK4
Transcriptional regulation of pluripotent stem cells
R-HSA-452723
STAT3
Transcriptional regulation of white adipocyte differentiation
R-HSA-381340
CDK4
CDK8
Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1445148
PRKAG2
AKT1
AKT2
PRKAA2
PRKAG1
Translocation of ZAP-70 to Immunological synapse
R-HSA-202430
ZAP70
LCK
Triglyceride catabolism
R-HSA-163560
PRKACB
PRKACA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-450513
MAPKAPK2
TRKA activation by NGF
R-HSA-187042
NTRK1
Truncations of AMER1 destabilize the destruction complex
R-HSA-5467348
GSK3B
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
R-HSA-9860927
PTK2
ABL1
IKBKE
CHUK
IKBKB
Ub-specific processing proteases
R-HSA-5689880
MAP3K7
TNKS2
TGFBR1
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-69601
CHEK2
CHEK1
Ubiquitin-dependent degradation of Cyclin D
R-HSA-75815
GSK3B
CDK4
UCH proteinases
R-HSA-5689603
TGFBR2
TGFBR1
Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-438066
CAMK2B
CAMK2D
CAMK2G
CAMK2A
Uptake and function of anthrax toxins
R-HSA-5210891
MAP2K4
MAP2K7
MAP2K6
MAP2K1
MAP2K3
MAP2K2
Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-432040
PRKACB
PRKACA
VEGF binds to VEGFR leading to receptor dimerization
R-HSA-195399
FLT1
FLT4
KDR
VEGFA-VEGFR2 Pathway
R-HSA-4420097
PTK2
MAPK12
ROCK2
PIK3CB
MAPKAPK2
PIK3CA
ROCK1
AXL
PRKACB
FYN
PAK2
PTK2B
SRC
KDR
MAPK13
PRKACA
VEGFR2 mediated cell proliferation
R-HSA-5218921
PRKCD
PDPK1
SRC
PRKCA
KDR
VEGFR2 mediated vascular permeability
R-HSA-5218920
AKT1
AKT2
AKT3
PAK2
PAK3
PDPK1
PAK1
WNT mediated activation of DVL
R-HSA-201688
CSNK2A1
CSNK2A2
WNT5:FZD7-mediated leishmania damping
R-HSA-9673324
MAPK8
WNT5A-dependent internalization of FZD4
R-HSA-5099900
PRKCA
XAV939 stabilizes AXIN
R-HSA-5545619
TNKS2
XBP1(S) activates chaperone genes
R-HSA-381038
GSK3A
YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-2032785
HIPK1
HIPK2
References
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2022 Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemia.
Dokla EME, Abdel-Aziz AK et al. Bioorg Med Chem
2022 FLT3 inhibitors for acute myeloid leukemia: successes, defeats, and emerging paradigms.
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Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute (dataset)
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Purified N370S Glucocerebrosidase. (Class of assay: confirmatory) [Related pubchem assays: 2101 ] AID 2597
PKIDB (dataset)
Cell lines
569
8.3
BaF3
8.06
EOL1
8
JAR
7.87
CHL-1
7.87
H4
7.87
MC-IXC
7.86
HD-MY-Z
7.78
ES5
7.77
KE-37
7.72
Kasumi 1
7.71
NB14
7.64
BB65-RCC
7.63
A-427
7.62
A3-KAW
7.58
697
7.58
P12-Ichikawa
7.57
SK-MEL-2
7.57
MHH-PREB-1
7.53
JVM-3
7.5
LoVo
7.5
SK-HEP1
7.48
MV4-11
7.46
H9
7.43
NCI-H209
7.42
KM12
7.39
HT-1080
7.37
SW982
7.36
CGTH-W-1
7.33
DEL
7.33
SK-MES-1
7.33
HSC-3
7.33
NKM-1
7.31
NCI-H720
7.31
LAMA-84
7.3
M14
7.28
KARPAS-45
7.25
HMV-2 cell line
7.22
SBC-1
7.21
RS4-11
7.17
A101D
7.16
AGS
7.15
MOLT-4
7.14
SW48
7.14
MMAC-SF
7.11
ACN
7.11
LB1047-RCC
7.09
5637
7.08
CHP-212
7.08
A4-Fuk
7.08
U2OS
7.08
VMRC-RCZ
7.05
MOLT-16
7.04
NCI-H292
7.03
A2780
7.03
QIMR-WIL
7.02
ES1
7.02
D-566MG
7.02
ES7
7.01
DU-4475
6.98
ACHN
6.98
ATN-1
6.96
SH-4
6.95
IST-SL1
6.95
SK-NEP-1
6.92
MEL-HO
6.91
8-MG-BA
6.91
RPMI-8866
6.9
ES3
6.9
EW-3
6.9
LB2241-RCC
6.89
ES4
6.89
P30-OHK
6.89
HCC1806
6.89
SW1710
6.88
D283 Med
6.88
ES8
6.88
EW-11
6.87
ONS-76
6.87
YH-13
6.86
KGN
6.86
HCT-116
6.85
NCI-H1048
6.85
PA-1
6.84
SK-N-AS
6.84
U-266
6.84
K5
6.83
CaR-1
6.83
HL-60
6.83
L-363
6.83
MLMA
6.83
NOMO-1
6.83
RH-1
6.82
EFM-19
6.82
A204
6.81
EPLC-272H
6.81
SW 962
6.8
SK-MEL3
6.8
KY821
6.8
FTC-133
6.79
BT-549
6.79
NBsusSR
6.76
ALL-PO
6.76
GI-ME-N
6.76
SF-539
6.75
CAL-54
6.75
GP5d
6.75
HCE-T
6.74
C32
6.74
HN
6.74
SNU1
6.73
DOHH-2
6.73
TYK-nu
6.73
HTC-C3
6.73
NCI-H1755
6.72
COLO-800
6.72
CTV-1
6.72
MC116
6.72
HGC-27
6.71
A549
6.71
D-336MG
6.71
ML-2
6.71
IST-MEL1
6.7
NH-12
6.69
Ramos-2G6-4C10
6.69
HSC-4
6.69
NCI-H520
6.69
HEL
6.67
SJSA-1
6.66
A498
6.66
G-361
6.65
SK-OV-3
6.65
EW-16
6.64
PSN1
6.63
Detroit 562
6.63
TI-73
6.63
HOS
6.63
MZ2-MEL
6.62
GB-1
6.61
A2058
6.61
RVH-421
6.6
BFTC-905
6.6
BFTC-909
6.6
TK-10
6.59
CAL-62
6.59
SK-LU-1
6.59
SK-N-DZ
6.59
SBC-5
6.59
SKG-IIIa
6.59
LC-2-ad
6.58
EW-24
6.57
NEC8
6.56
CAL-51
6.56
SF-126
6.56
MDA-MB-157
6.55
BE-13
6.55
NCI-H1395
6.54
SW 954
6.53
DOK
6.53
LOX IMVI
6.53
HO-1-N-1
6.52
8505C
6.52
RKO
6.51
ECC10
6.51
HAL-01
6.51
GAK
6.5
RPMI-7951
6.49
SK-MEL-28
6.49
SW780
6.49
MHH-ES-1
6.49
LS-411N
6.49
T98G
6.49
SF-268
6.49
YKG-1
6.49
KOSC-2
6.49
GCT
6.48
A-375
6.48
CAKI-1
6.48
MFM-223
6.47
CAL-120
6.47
PANC-03-27
6.47
NB10
6.46
OAW-42
6.46
NCI-H1703
6.45
LNCaP-Clone-FGC
6.45
SK-UT-1
6.45
NCI-H1581
6.44
C2BBe1
6.44
J-RT3-T3-5
6.44
NTERA-2-cl-D1
6.43
BV-173
6.43
KS-1
6.43
MN-60
6.43
HEC-1
6.42
COLO-679
6.42
NB17
6.42
GAMG
6.41
A-431
6.41
RPMI-8226
6.41
GT3TKB
6.41
KYSE-270
6.41
SK-PN-DW
6.41
VA-ES-BJ
6.4
SN12C
6.39
D-502MG
6.39
MOLT-13
6.39
KG-1
6.39
NMC-G1
6.39
LB2518-MEL
6.38
NB69
6.38
TE-9
6.37
H-EMC-SS
6.37
SF-295
6.37
LCLC-97TM1
6.37
LK-2
6.36
CAL-27
6.36
MSTO-211H
6.36
G-401
6.35
EM-2
6.35
MG-63
6.35
KYSE-140
6.35
PC-14
6.35
HT-3
6.34
IGROV-1
6.34
MEG-01
6.33
BHT-101
6.33
NB13
6.33
GMS-10
6.33
RT-112
6.33
NB5
6.32
CAL-39
6.31
NCI-H2052
6.31
GR-ST
6.3
CTB-1
6.3
HH
6.3
OVCAR-5
6.3
MEL-JUSO
6.29
SK-MEL-30
6.29
M059J
6.29
NCI-H510A
6.28
D-247MG
6.27
EC-GI-10
6.27
UACC-257
6.26
GI-1
6.26
TE-1
6.26
HCC 2998
6.26
KINGS-1
6.25
SW-620
6.25
OS-RC-2
6.25
HuO9
6.25
HCT-15
6.25
KP-4
6.24
EGI-1
6.24
D-423MG
6.23
D-392MG
6.23
MDA-MB-231
6.22
EKVX
6.22
LU-134-A
6.22
SNU-387
6.22
HuO-3N1
6.22
MZ7-mel
6.21
TE-11
6.21
KMOE-2
6.21
SW13
6.2
CP50-MEL-B
6.2
SW756
6.2
SAOS-2
6.2
EW-18
6.19
KYSE-150 cell line
6.19
VM-CUB-1
6.19
HuTu80
6.19
FaDu
6.18
DJM-1
6.18
COR-L23
6.18
HT-29
6.18
TE-8
6.17
NCI-H650
6.17
ESS-1
6.16
639-V
6.16
KALS-1
6.16
NCI-H1573
6.15
KP-N-YS
6.14
A673
6.14
CAL-33
6.14
Becker
6.14
JEG-3
6.14
SNU-423
6.14
MeWo
6.13
ME-180
6.12
OVCAR-8
6.12
SCC-25
6.11
NCI-H727
6.1
DB
6.09
RERF-LC-MS
6.08
23132-87
6.08
NCI-H28
6.07
COLO-684
6.07
MIA PaCa-2
6.07
ETK-1
6.06
CAL-12T
6.06
BHY
6.06
EW-22
6.06
HuCCT-1
6.06
SW1088
6.05
Ca9-22
6.05
NB7
6.05
NCI-H1792
6.04
HOP-92
6.04
RXF 393
6.04
HC-1
6.04
NCI-H1155
6.03
BB30-HNC
6.03
GOTO
6.03
NB6
6.03
NCI-H1299
6.02
SAS
6.02
NOS-1
6.01
A704
6.01
BCPAP
6.01
D-263MG
6.01
HT-144
6.01
HuP-T3
6
DSH1
6
647-V
6
NCI-H810
6
Hs-578T
5.99
EFO-27
5.99
KU812 cell line
5.99
LU-99A
5.99
LXF-289 cell line
5.98
Daoy
5.98
CAMA-1
5.98
NCI-H747
5.98
MPP-89
5.97
EW-1
5.97
OCI-AML2
5.97
SW1573
5.96
DK-MG
5.96
MHH-NB-11
5.96
SK-N-FI
5.96
G-402
5.95
SW626
5.95
MKN-45
5.95
S-117
5.95
HT
5.95
UACC-62
5.95
UMC-11
5.95
SNU-C2B
5.94
UMUC3
5.94
MDA-MB-175-VII
5.93
COLO-829
5.93
OMC-1
5.93
NCI-H460
5.93
SW1417
5.92
SCC-9
5.92
RPMI-2650
5.91
AN3-CA
5.91
NCI-H2009
5.9
NCI-H1975
5.9
LS-513
5.9
MDA-MB-361
5.88
BPH-1
5.88
KU-19-19
5.88
NB12
5.88
NCI-H2030
5.88
HuP-T4
5.87
SCC-4
5.86
SW1990
5.86
HLE
5.85
CWR22R
5.85
SW900
5.85
KYSE-410
5.85
TGBC11TKB
5.84
COLO-741
5.83
SNB-75
5.83
TE-10
5.83
IGR-1
5.83
KNS-81-FD
5.82
DMS-114
5.82
HSC-2
5.81
786-0
5.81
NCI-H2452
5.8
RCM-1
5.8
SW1783
5.79
ASPC1
5.79
769-P
5.78
AU565
5.78
BB49-HNC
5.78
BT-20
5.78
NCI-H1623
5.77
PC-3
5.77
NCI-H23
5.74
MKN-7
5.74
NCI-H2291
5.74
NCI-H2405
5.74
OC-314
5.73
TCC-SUP
5.72
SW684
5.72
NCI-H2122
5.72
MDA-MB-453
5.72
NCI-H1666
5.72
NCI-H446
5.72
SJRH30
5.71
ChaGo-K-1
5.71
A 172
5.71
KYSE-520 cell line
5.71
KP-N-YN
5.68
HPAF-II
5.67
DU-145
5.67
MDA-MB-415
5.66
Panc1005
5.65
HCC1187
5.65
KLE
5.65
HCE-4
5.63
NCI-H630
5.63
NCI-H2087
5.63
LB831-BLC
5.63
NCI-H358
5.63
OCUB-M
5.62
TE-5
5.61
CAS-1
5.61
CCRF-CEM
5.61
CFPAC-1
5.61
SiHa
5.61
LAN-6
5.61
HCC38
5.61
LCLC-103H cell line
5.6
C3A
5.59
LS-123
5.59
SNU-449
5.58
Calu-3
5.58
KYSE-510
5.58
T-24
5.56
Calu-6
5.56
no-11
5.55
SK-MEL-24
5.54
C-33-A
5.54
OE33
5.54
KM-H2
5.54
KNS-62
5.53
COLO-792
5.53
DMS-273
5.53
AM-38
5.51
CAPAN-1
5.51
TE-12
5.5
Ca-Ski
5.5
LN-405
5.5
KYSE-70 cell line
5.5
SCH
5.5
MCF7
5.47
U-118-MG
5.47
NCI-N87
5.47
NCI-H226
5.46
NCI-H2170
5.46
LB771-HNC
5.45
ES6
5.45
SHP77
5.44
8305C
5.43
CP66-MEL
5.43
OVCAR-3
5.43
HT-1376
5.43
WM-115
5.42
BT-474
5.42
IA-LM
5.41
SW948
5.41
NCI-H2126
5.41
NCI-H1355
5.41
PFSK-1
5.41
GCIY
5.39
HCC1395
5.38
COLO-680N
5.38
NCI-H596
5.37
A388
5.36
COR-L105
5.36
LB373-MEL-D
5.35
HOP-62
5.35
NCI-H1651
5.34
J82
5.33
BEN
5.33
NCI-H2029
5.32
HT55
5.32
NCI-H2347
5.3
U-87 MG
5.3
no-10
5.3
NUGC-3
5.29
OVCAR-4
5.27
Huh-7
5.26
COLO-678
5.24
NCI-H2342
5.24
NCI-H1437
5.23
SCC-15
5.21
NCI-H1838
5.21
LU-139
5.21
RH-18
5.2
TGBC1TKB
5.19
NCI-H661
5.19
NCI-H69
5.19
OAW-28
5.18
BXPC-3
5.17
NCI-H441
5.16
EFO-21
5.16
IST-MES1
5.15
KURAMOCHI
5.12
MZ1-PC
5.12
TE-6
5.12
Mo
5.11
Capan-2
5.11
MKN-28
5.1
NCI-H1563
5.09
HCC70
5.08
COLO-824
5.06
KNS-42
5.05
SK-MEL-1
5.05
RMG-I
5.03
KYSE-180
5.02
NCI-H1092
5.01
HCC1937
5.01
RO82-W-1
5
YAPC
5
NY
4.97
COR-L88
4.93
HT1197
4.92
SK-LMS-1
4.91
MFH-ino
4.91
T47D
4.9
ABC-1
4.88
SW 1116
4.87
L-428
4.84
DoTc2-4510
4.84
CAL-85-1
4.84
MKN-1
4.83
KYSE-450
4.83
EW-13
4.83
ZR-75-30
4.81
DBTRG-05MG
4.81
MFE-280
4.75
LU-135
4.74
HCC1954
4.73
NCI-H1770
4.72
NCI-H526
4.7
RCC10RGB
4.68
MS-1
4.6
NCI-H1650
4.59
TGBC24TKB
4.58
CAL-72
4.58
RD
4.54
SW1463
4.52
NCI-H1648
4.49
D-542MG
4.49
U-251
4.4
C8166
4.4
HCC2218
4.37
NCI-H2228
4.37
T84
4.36
SW872
4.3
COLO-320-HSR
4.28
KARPAS-299
4.26
NCI-H1304
4.23
HCC1419
4.22
COLO-668
4.22
PANC-08-13
4.2
SW837
4.18
SNU-5
4.16
UO-31
4.15
OE19
4.15
JVM-2
4.14
NCI-H1693
4.1
NCI-H1793
4.1
Lu-65
4.06
NCI-H1993
Organisms
0
Compound Sets
15
Cayman Chemical Bioactives
12094
ChEMBL Drugs
CHEMBL603469
Clinical kinase drugs
DrugBank
DB06469
DrugMAP
DMQ2AIJ
Guide to Pharmacology
5672
LINCS compound set
10230-999
10230-101
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL603469
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL603469
MedChem Express Bioactive Compound Library
HY-50867
Nuisance compounds in cellular assays
Obsolete Compounds
lestaurtinib
PKIDB
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
Welcome Trust Cancer Drugs
1024
Available from
4
Cayman Chemical Bioactives
12094
Mcule
MCULE-5638694843
MCULE-7208220282
MedChem Express Bioactive Compound Library
HY-50867
MolPort
MolPort-003-848-372
Molport-003-848-372
External IDs
36
ChEMBL CHEMBL603469
GtoPdb 5672
PubChem 126565
ZINC ZINC000003781738
ACToR 111358-88-4
BindingDB 50308060
Brenda 27072
ChEBI 91471
ChemicalBook CB3506750
ChemSpider 112457
ClinicalTrials.gov LESTAURTINIB SPM-924 KT5555 CEP-701 KT-5555 SP924 KT-555 SP-924
COCONUT CNP0527731.1
CompTox DTXSID5046778
DrugBank DB06469
eMolecules 10484307 36500496
FDA SRS DO989GC5D1
GSRS 10797da6-df66-4...
IBM NIH E78707620264CCB...
LINCS LSM-1231
Mcule MCULE-5638694843 MCULE-7208220282
MolPort MolPort-003-848-372 Molport-003-848-372
PDB 2V9
PubChem DOTF 26683764
PubChem TPS 14881395
Reactome 112457
SureChEMBL SCHEMBL1649693
Properties
(calculated by RDKit )
Molecular Weight
439.15
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
8
Aromatic Ring Count
5
cLogP
3.47
TPSA
88.65
Fraction CSP3
0.27
Chiral centers
3.0
Largest ring
7.0
QED
0.37
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
Nonspecific kinase inhibition
Nuisance compounds
Custom attributes
(extracted from source data)
Pathway
RTK signaling
Apoptosis
Epigenetics
JAK/STAT Signaling
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
Target
FLT3, JAK2, NTRK1, RET
FLT3
JAK
STAT
Trk Receptor
Targets
JAK2,FLT3,NTRK1
Cellular injury category
Kinase
Therapeutic Class
Anticancer Agents
Source data