General
Preferred name
ALACEPRIL
Synonyms
Cetapril ()
DU-1219 ()
NSC-338157 ()
P&D ID
PD072286
CAS
74258-86-9
219554-02-6
Tags
available
drug
Approved by
FDA
First approval
1981
Drug indication
Cardiovascular disease
Drug Status
approved
investigational
Max Phase
2.0
Structure
ALACEPRIL
approved
RO5
MW
406.16
HBA
5
HBD
2
RB
8
LOGP
1.71
16
10
0
1
Structure formats
SMILES
CC(=O)SC[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
InChI
InChI=1S/C20H26N2O5S/c1-13(12-28-14(2)23)19(25)22-10-6-9-17(22)18(24)21-16(20(26)27)11-15-7-4-3-5-8-15/h3-5,7-8,13,16-17H,6,9-12H2,1-2H3,(H,21,24)(H,26,27)/t13-,16+,17+/m1/s1
InChIkey
FHHHOYXPRDYHEZ-COXVUDFISA-N
MOL
ALACEPRIL RDKit 2D 28 29 0 0 0 0 0 0 0 0999 V2000 -9.3637 0.1644 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -8.3600 -0.9503 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -8.8235 -2.3769 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -6.8928 -0.6385 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 -5.8891 -1.7532 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.4218 -1.4413 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.9583 -0.0147 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.4182 -2.5560 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.9509 -2.2442 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -3.8817 -3.9826 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 -5.3083 -4.4462 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.3083 -5.9462 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.8817 -6.4097 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.0000 -5.1962 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5000 -5.1962 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.7500 -6.4952 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.7500 -3.8971 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 0.7500 -3.8971 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5000 -2.5981 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7500 -1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7500 1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.7500 1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.7500 -1.2990 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5000 -5.1962 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0000 -5.1962 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.7500 -6.4952 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 2 0 2 4 1 0 4 5 1 0 5 6 1 0 6 7 1 1 6 8 1 0 8 9 2 0 8 10 1 0 10 11 1 0 11 12 1 0 12 13 1 0 13 14 1 0 14 15 1 6 15 16 2 0 15 17 1 0 17 18 1 0 18 19 1 1 19 20 1 0 20 21 2 0 21 22 1 0 22 23 2 0 23 24 1 0 24 25 2 0 18 26 1 0 26 27 2 0 26 28 1 0 14 10 1 0 25 20 1 0 M END > <ID> PD072286 > <Name> ALACEPRIL
Protein targets
1
4.68
OPRK1 Kappa-type opioid receptor
3
1
Target pathways
3
G alpha (i) signalling events
OPRK1
MECP2 regulates neuronal receptors and channels
OPRK1
Peptide ligand-binding receptors
OPRK1
References
2
2023 A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.
Sutherland JJ, Yonchev D et al. Nat Commun
Screening of ~5500 FDA-approved drugs and clinical candidates for anti-SARS-CoV-2 activity (dataset)
Compound Sets
10
ChEMBL Drugs
Drug Repurposing Hub
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Available from
4
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Properties
(calculated by RDKit )
Molecular Weight
406.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
1
cLogP
1.71
TPSA
103.78
Fraction CSP3
0.5
Chiral centers
3.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Member status
member
MOA
Angiotensin-I Converting Enzyme (ACE) Inhibitors
angiotensin converting enzyme inhibitor
Indication
hypertension
Target
ACE
Angiotensin-converting Enzyme (ACE)
Pathway
Metabolic Enzyme/Protease
Source data